immunologics with condition Flashcards
etanercept
anti-TNFalpha antibody
moderate to severe rheumatoid arthritis
infliximab
Anti-TNFalpha monoclonal antibody
great for any inflammatory conditions including RA, IBD; Crohn’s Disease; Ulcerative Colitis
anakinra
Anti-IL-1 antibody
RA and IBD (Crohn’s)
tofacitinib
Janus Kinase inhibitor
RA, Psoriatic Arthritis, Ulcerative Colitis
upadacitinib
Janus Kinase inhibitor
RA, Psoriatic Arthritis, IBD
omalizumab (Xolair)
Monoclonal Anti-IgE Antibodies
txt moderate to severe forms of allergic asthma; advantages include improved lung functions, a reduction in asthmatic attacks, and reduced txt with glucocorticoids
cyclosporine
(calcineurin inhibitor/IL-2 inhibitor)
decreases the activity of cell-mediated immunity and humoral immunity; used to prevent organ and tissue transplant rejection; also used to treat psoriasis, rheumatoid arthritis, and chronic dry eyes (ophthalmic preparations)
reslizumab
IL-5 receptor antagonist
severe eosinophilic asthma
vaccines, immunizations = type of immunity?
active/passive/selective/nonselective
active, selective
CAR T-cell therapy
blood cancers
BCG vaccine
active, non-selective for what condition?
TB (active selective)
bladder cancer (active nonselective)
antibody therapy (IVIg) = what type?
active/passive/selective/nonselective
passive, selective
secukinumab
anti-IL-17A monoclonal antibody
psoriasis and psoriatic arthritis
ustekinumab
anti- IL-12 and IL-23 monoclonal antibody
Crohn’s Disease/Inflammatory Bowel Disease, etc.
tocilizumab
anti-IL-6 monoclonal antibody
treatment may reduce the duration and/or severity of COVID-19 illness;
txt of moderate to severe rheumatoid arthritis, etc.
granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte, colony stimulating factor (G-CSF); interleukin 2 (IL-2)
passive, non-selective
used in the treatment of immunodeficiency conditions associated with AIDS, radiation, and chemotherapy; also used following bone marrow transplantation
granulocyte macrophage colony stimulating factor (GM-CSF), granulocyte, colony stimulating factor (G-CSF); interleukin 2 (IL-2) = what type?
active/passive/selective/nonselective
passive, non-selective
nivolumab
anti-PD-1 inhibitor
effective against melanoma, non-small cell carcinoma, pancreatic cancer, etc.
avelumab
anti-PD-L1 inhibitor
“Merkel cell carcinoma (rare skin cancer — one of the few drugs approved)
Urothelial carcinoma (bladder)
Renal cell carcinoma”
