PreOp Meds: Dopa Blockers - Metoclopramide (Reglan)

Question 1

What drug is used for diabetic gastroparesis?

Answer 1

• Metoclopramide (Reglan)

Question 2

Which dopamine blocker can decrease plasma cholinesterase levels?
What is the consequence of this?

Answer 2

• Metoclopramide
• ↓ metabolism of succinylcholine, mivacurium, & ester local anesthetics.

Question 3

What is the dosing for metoclopramide?
When should it be given?

Answer 3

• 10-20 mg IV over 3-5min
• 15-30 min prior to induction

Question 4

What drugs can potentially cause neuroleptic malignant syndrome?
What are the symptoms of this syndrome?

Answer 4

• Metoclopramide & Droperidol
• ↑temp, muscle rigidity, ↑HR, & confusion

Question 5

Which dopamine blockers can potentially increase prolactin secretion?
Where is prolactin secreted from?

Answer 5

• Metoclopramide & Domperidone
• Pituitary gland