PreOp Meds: Corticosteroids & Dexamethasone Flashcards
1
Q
What are the three prevailing theories for corticosteroid’s mechanism in treatment of PONV?
A
- CNS prostaglandin inhibition suppressing endorphin release
- ↑ effectiveness of 5HT3 antagonists & droperidol
- Anti-inflammatory = less opioid usage.
2
Q
A patient is on 100mg hydrocortisone Q8 for 24 hours post-operatively, what dose of dexamethasone would you give?
A
- No Dexamethasone
3
Q
What is the time till onset of Dexamethasone?
How long does efficacy persist?
A
- Onset: 2 hours
- 24 hours of efficacy
4
Q
What is the primary adverse effect of dexamethasone?
A
- Perineal burning/itching
5
Q
What is the normal dosing for dexamethasone? When would one consider giving more?
A
- 4 - 8 mg
- Consider 12mg if difficult airway or swelling exists.
