Multimodal: Corticosteroid- Dexamethasone Flashcards
1
Q
What is the MOA of Corticosteroids in the treatment of N/V?
A
MOA is unknown
It works on glucocorticoid receptors in Nucleus Tractus Solitarius (NTS).
S51
2
Q
What is the dose for Dexamethasone (Decadron)?
A
8 - 10 mg IV
S52
3
Q
Are there any adverse effects of a single dose of Dexamethasone (Decadron)?
What occurs if it is pushed fast?
A
- Nope
- Perineal burning/itching
S52
4
Q
Why are Corticosteroids used with 5-HT3 (Ondansetron) & Droperidol?
A
Increase effectiveness for 5 HT3 antagonists and Droperidol
S51
5
Q
What is the MOA of Dexamethasone (Decadron)?
A
- Anti-inflammatory
- inhibition of phospholipase and cytokines and stabilization of cellular membrane.
S52
6
Q
What is the delay of onset of Dexamethasone (Decadron)?
A
2 hours
S52
7
Q
What is the efficacy of Dexamethasone (Decadron)?
A
24 hours
S52
