Pharm Adjunct: Nitro-vasodilator - Sodium Nitroprusside Flashcards
1
Q
What does Nitroprusside dissociate on contact with?
What is the result?
A
Dissociates on contact with oxyhemoglobin → methemoglobin, NO, and cyanide released.
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2
Q
What does nitroprusside vasodilate?
A
Arterial and venous vasculature
but MORE ARTERIAL
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3
Q
What vasodilator absolutely requires arterial line monitoring?
A
Nitroprusside.
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4
Q
What is the dose of Nitroprusside?
A
0.3 - 2 mcg/kg/min
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5
Q
When is nitroprusside used?
A
- Hypotensive necessary surgeries (aortic, spine, etc.)
- Hypertensive emergencies (post CEA’s)
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6
Q
What drug is used to treat cyanide toxicity?
A
Methylene blue
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7
Q
What signs would tip you off to possible cyanide toxicity secondary to nitroprusside administration?
A
- ↑ need for nitroprusside dose
- ↑ SvO₂
- Metabolic acidosis
- LOC changes
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