Pharm Adjunct: Beta Blockers concept Flashcards
β agonism results in activation of _____ which then produces _______.
Adenylyl Cyclase (AC)
cAMP
S2
Does Ca⁺⁺ influx or efflux during β agonism?
Influx
S2
What type of receptors are β receptors?
GPCR
S2
What types of β receptors are there and where are they primarily located?
- β1 - Heart
- β2 - Lungs
- β3 - Fat/Muscle
S3
Chronic administration of β blockers results in what effect on receptors?
Receptor upregulation (aka ↑ # of receptors)
After β receptor desensitization from prolonged catecholamine exposure, what drug class can restore receptor responsiveness?
β-blockers
How do β blockers protect myocytes from perioperative ischemia?
By ↓O₂ demand on the heart
T/F. β blockers will potentiate renin release.
false. β blockers will inhibit renin release
decreases C.O.
How will β blockers affect the cardiac foci action potential?
Prolong Phase 4
↓ dysrhythmias during ischemia and reperfusion.
How will β blockers affect diastolic perfusion time?
β blockers will increase diastolic perfusion time.
What type of HTN is a possible indication for β blocker therapy?
Essential Hypertension
Sy
What is SCIP?
Describe the protocol and its goals.
- Surgical Care Improvement Protocol
- β-blockers must be given within 24 hrs of surgery for patients at risk for cardiac ischemia and ones already on β-blocker therapy.
S7
What were the three β1 selective agents discussed in lecture?
- Metoprolol
- Atenolol
- Esmolol
not cause vasodilation
S9
What percentage of β receptors in the myocardium are β1 ?
75%
S9
Do cardio-selective β-blockers cause vasodilation?
No
S9
