Induction Meds: Opioids Agonist-Antagonist - Pentazocine Flashcards
1
Q
A
2
Q
How potent is Pentazocine?
A
1/5 as potent as Morphine
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3
Q
What receptors does pentazocine bind to?
What type of activity does it exhibit?
A
- κ & δ receptor
-Agonist effects with weak antagonist activity
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4
Q
How is Pentazocine excreted?
A
Glucuronide conjugates in the urine.
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5
Q
Which opioid agonist-antagonist crosses the placental barrier causing fetal depression?
A
Pentazocine
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6
Q
What is the chronic pain dose of Pentazocine?
What dose and route would be equivalent to Morphine 10mg?
A
- 10 - 30mg IV or 50 mg PO
- 20-30mg IM= 10mg Morphine
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7
Q
What is Pentazocine antagonized by?
A
Naloxone
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8
Q
What is the elimination 1/2 time of Pentazocine?
A
2 - 3 hours
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9
Q
What are the side effects of Pentazocine?
A
- sedation
- diaphoresis
- dizziness
- dysphoria (high doses)
- increased HR, BP, PA bp, LVEDP
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10
Q
What is the epidural analgesia duration of Pentazocine?
A
Shorter duration < Morphine
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