Multimodal: Gabapentin Flashcards
1
Q
Regarding Gabapentin’s preemptive analgesia, What 3 studies/ procedures is it used in?
A
- Spine surgeries
- Orthopedic procedures
- Major abdominal procedures.
S27
1
Q
What is the PO dose of preemptive Gabapentin?
When should we give it?
A
300-1200mg PO
1-2 hrs prior to OR
start slow then build up
S27
2
Q
For Preemptive Gabapentin, what patient population is it contraindicated for?
A
- MG and Myoclonus patients
- Reduce dose in elderly patients
S27
3
Q
What are Gabapentin’s side effects?
A
Think ↑GABA effects
- Somnolence
- fatigue
- ataxia
- vertigo
- GI disturbances: constipation
- abrupt withdrawal in seizure pts (when Gaba is used as an antiepiliptic) –> causing seizures
- wt gain
S29
4
Q
Is Gabapentin lipid soluble?
What percentage protein-binding occurs?
What’s it’s E 1/2 time?
A
- Yes, Lipid soluble
- 0% protein-bound
- Brief E 1/2 time – need redosing required
S25
5
Q
Does Gabapentin have any drug-drug interactions?
A
No drug interactions
S25
6
Q
What are indicated uses for gabapentin?
A
- Seizures
- Neuropathic pain
- Chronic pain syndromes.
S26
7
Q
What is the MOA of Gabapentin?
A
GABA analogue
(not act like GABA)
Binds voltage gated Ca++ channels:
enhances descending inhibition
inhibits excitatory neurotransmitter release
S25*
