Pre-anes Tranquilizers/sed P2 (a2 agonists)

Question 1

Difference between an agonist and antagonist

Answer 1

Agonist: stimulates receptors
Antagonist: suppresses receptors

Question 2

Transmitters of sympathetic NS (2)

Answer 2

Epinephrine (adrenaline) and norepinephrine

Question 3

The two receptors that epinephrine or norepinephrine could stimulate

Answer 3

Beta receptors or alpha2 receptors

Question 4

What stimulation of beta receptors causes

Answer 4

Fight or flight response

Question 5

What stimulation of alpha 2 receptors does

Answer 5

Causes sedation, analgesia, bradycardia, hypotension, hypothermia

Question 6

Alpha2- adrenoceptor agonists do what to the alpha 2 receptors

Answer 6

Stimulate (bind to them), stimulating their effects

Question 7

Desirable effects of a2 adrenoceptor agonists

Answer 7

Sedation, analgesia

Question 8

Because of how sleep an a2 adrenoceptor drug makes an animal, we can reduce the amount of gen anesthesia _____%

Answer 8

50-80%

Question 9

How long a2 agonists analgesia lasts

Answer 9

<15-20min

Question 10

Cardiac output (CO) refers to

Answer 10

Volume of blood flow to heart

Question 11

Tidal volume

Answer 11

Volume of gas inhaled in one breath

Question 12

Repressed peristalsis, an undesirable effect of a2 agonist drugs, causes what in cattle and what in dogs

Answer 12

Cattle: bloat
Dogs: gastric dilation (stomach becomes overstretched and rotated by excessive gas content)

Question 13

Why you should be cautious around an animal sedated by a2 agonist drugs

Answer 13

Unpredictable, can become aggressive, decreased bite inhibition

Question 14

Why a2 agonist drugs can increase blood glucose levels

Answer 14

Suppression of pancreas secretion of insulin (allows glucose to be used as energy)

Question 15

Diuresis

Answer 15

Increased urination

Question 16

Why you should be cautious giving an animal w renal or liver disease an a2 agonist drug

Answer 16

Drugs are metabolized in liver, excreted in urine

Question 17

Which route of admin. Do we not use for a2 agonists

Which one stings but is still done?

Answer 17

SQ, unpredictable

IM stings

Question 18

A2 agonist drugs

Answer 18

Xylazine or dexmedetomidine

Question 19

Brands of xylazine

Answer 19

Rompun or AnaSed

Question 20

Reversing agent for xylazine

Reversing agent for ruminants

Answer 20

Yohimbine (chem) yobine (brand)

Ruminants: tolazoline (chem)

Question 21

Dexmedetomidine brand for dogs/cats and horses

Answer 21

D/C: dexdomitor

Horses: detomidine or dormosedan

Question 22

Route of administration for dexmedetomidine

Answer 22

IV or IM (PO for horses)

Question 23

Dexmedetomidine is (deeper or lighter) than xylazine

Answer 23

Deeper

Question 24

Reversing agent for dexmedetomide

Answer 24

Atipamezole (chem) Antisedan (brand)

Question 25

Route of administration for atipamezole (antisedan)

Answer 25

IM: d/c
IV: dogs only