PR INTESTINAL COCCIDIANS & BABESIA Flashcards

1
Q

Apicomplexans found in the small intestine

A

Intestinal coccidians

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2
Q

Intestinal coccidians

FInal host

A

man

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3
Q

Intestinal coccidians

Reservoir hosts

A

animals

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4
Q

Intestinal coccidians

Partially acid fast possess

A

mycolic acid

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5
Q

Intestinal coccidians

Infective stage

A

sporulated oocyst

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6
Q

Intestinal coccidians

MOT

A

ingestion of sporulated oocyst (contaminated food and water)

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7
Q

Most common species infecting man

A

Cryptosporidium hominis

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8
Q

Cryptosporidium hominis

Habitat

A

small intestine (jejunum)

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9
Q

Cryptosporidium hominis

Target cells

A

enterocytes (intestinal cells, columnar cells with microvilli, brush border)

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10
Q

Cryptosporidium hominis

Large multiplication capability

A

autoinfection caused by the two types of cysts

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11
Q

Cryptosporidium hominis

MOT

A
  • Ingestion of sporulated oocyst
  • Drink contaminated water
  • Swim in recreational pools that are fecally contaminated
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12
Q

Cryptosporidium hominis

Disease Manifestation for Healthy Immunocompetent Patients

A
  • Watery diarrhea (5-10 frothy bowel movements)
  • Usually self-limiting (disappears in 2-3 weeks)
  • Important cause of outbreaks of diarrhea
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13
Q

Cryptosporidium hominis

Disease Manifestation for Immunocompromised patients

A
  • Chronic diarrhea
  • Extraintestinal infections
  • Cholecystitis
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14
Q

Cryptosporidium hominis

Pathology

A

Changes in the morphology of the villi
- blunted
- atrophy of villi

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15
Q

Cryptosporidium hominis

Diagnosis

A

Sheather’s Sugar Floatation, FECT, Modified Kinyoun Method

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16
Q

Cryptosporidium hominis

Preferred Sample

A

Stool, Duodenal aspiratesq

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17
Q

Cryptosporidium hominis

Epidemiology

A

Zoonotic infection

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18
Q

Cryptosporidium hominis

Treatment

A

no standardized treatment
Nitazoxanide

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19
Q

classified as CLB (cyanobacterium like body)

A

Cyclospora cayetanensis

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20
Q

Difference of Cyclospora cayetanensis and Cyrptosporidium hominis

A

Slight change in morphology of sporulated oocyst (presence of
sporocyst)

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21
Q

Cyclospora cayetanensis

Sporocyst contains

A

contains 2 sporozoites inside; 4 sporozoites in 1 oocyst

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22
Q

Cyclospora cayetanensis

Oocyst released is

A

Oocyst released is unsporulated

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23
Q

Cyclospora cayetanensis

undeveloped/undifferentiated structures inside the
unsporulated oocyst

A

Morula formation

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24
Q

Cyclospora cayetanensis

MOT

A
  • Ingestion of sporulated oocyst
  • Drinking/eating contaminated food and water
  • Associated with eating salads, strawberries, raspberries, basils, vegetables, fruits (raw and not
    thoroughly washed)
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25
Cyclospora cayetanensis Disease manifestation
- Intermittent watery diarrhea - Development of d-xylose malabsorption
26
Cyclospora cayetanensis Diagnosis
modified kinyoun method)
27
Cyclospora cayetanensis Treatment
Self-limiting (no need for treatment), Co-trimoxazole
28
least common infecting man and largest oocyst
Cystoisospora belli
29
Cystoisospora belli Infective Stage
sporulated oocysts
30
Cystoisospora belli Oocyst
Oval-shaped, 2 sporocysts with 4 sporozoites each
31
Cystoisospora belli undifferentiated structures inside
Sporoblasts
32
Cystoisospora belli MOT
Oral-fecal
33
Cystoisospora belli Disease Manifestation and Pathogenesis
- Intermittent diarrhea - Infects intestinal cells of humans (duodenum) - Usually asymptomatic - Diarrhea with fever, malaise, anorexia, abdominal pain, and flatulence - Seen in immunocompromised patients
34
Cystoisospora belli Diagnosis
- Entero-test - Duodenal aspirates
35
Cystoisospora belli Epidemiology
More common among children, AIDS patients, MSMs
36
Cystoisospora belli Treatment
Trimethoprim-Sulfamethoxazole
37
Tissue cysts contain bradyzoites
Toxoplasma gondii
38
Parasite of cats
Toxoplasma gondii
39
Toxoplasma gondii intermediate host only (accidental)
Humans
40
Toxoplasma gondii Infective stage
sporulated oocyst or tissue cysts
41
Toxoplasma gondii MOT
- Ingestion of sporulated oocyst or tissue cysts - Eating contaminated food/drink with feces of cat - Vertical transmission (especially if mom is infected during pregnancy - Eating cats (possible)
42
Toxoplasma gondii Diagnostic stage
Bradyzoites, Tachyzoites
43
Toxoplasma gondii Late stages, Multiply slowly, develop in visceral organs
Bradyzoites
44
Toxoplasma gondii Rapidly multiply, early stages of infection, crescent-shaped
Tachyzoites
45
Toxoplasma gondii Disease manifestation
asymptomatic; no diarrhea
46
Toxoplasma gondii Diagnosis
Sabin-Feldman Test
47
almost all of us are actually exposed or positive for the parasite
Toxoplasma
48
Sabin-Feldman Test positive and negative result
1. Positive result: non-uptake of the dye (colorless) 2. Negative result: blue color
49
Toxoplasma gondii Treatment
Pyrimethamine and Sulfadiazine
50
Test used to detect congenital infections
TORCH Test
51
Toxoplasma gondii pathogenesis
Obligate intracellular parasites (invade nucleated cells including macrophages)
52
Blood-borne and vector-borne
Babesia spp.
53
Babesia is transmitted by
ticks
54
Babesia spp. type of parasite
Heteroxenous parasite
55
Babesia spp. MOT
- Bite of an infected tick (blood meal) - Blood transfusion - Vertical transmission - Organ transplant - Transovarian transmission
56
Babesia spp. DH and IH
DH : Tick IH : Mammals
57
Babesia spp. Infective stage to intermediate hosts
sporozoites
58
Babesia spp. Morphology
- no schizonts or gametocytes - Up to four trophozoites - Presence of up to four merozoites
59
Babesia spp. Arrangement of merozoites
- Maltese Cross Arrangement (four merozoites) - Bunny Ears/Rabbit Ears Appearance (two merozoites)
60
Babesia spp. Disease Manifestation
Babesiosis, Piroplasmosis, Nantucket Fever, Splenic Fever, Redwater Fever, Tick fever, or Texas Cattle Feve
61
T/F Babesia spp. has no paroxysmal cycle
True
62
Babesia spp. Signs and symptoms
Mild chills and fever, Hemolytic anemia
62
Babesia spp. Immunity
innate and acquired immunity contribute to resolution of the primary infection
63
Babesia spp. Diagnosis
Examination of Giemsa stained smears, Serology L IFAT, Inoculation of animals
64
Babesia spp. gold standard for Babesia detection
PCR
65
Babesia spp. Treatment
Combination of Clindamycin and Quinine