PPI Flashcards
1
Q
Describe the mechanism of action of proton pump inhibitors.
A
Irreversibly inactivates H+/K+/ATPase, inhibiting acid secretion for up to 24hrs (time taken for synthesis of new enzymes).
2
Q
Why is an IV infusion preferred to a single bolus dose?
A
PPIs only inactivate actively secreting acid pumps, hence a single dose will only decrease acid secretion for a few hours.
3
Q
Regarding oral formulations of proton pump inhibitors, please describe strategies used to increase their bioavailability and activity.
A
Taken as inactive pro-drugs
Acid-resistant enteric coating to prevent gastric elimination
Take on an empty stomach as food decreases the bioavailability
Take one hour prior to a meal so that peak plasma levels occur when most pumps are active
