NAC

Question 1

What is the mechanism of action of N-acetylcysteine in paracetamol overdose?

Answer 1

Note that for this question you need to explain the mechanism of paracetamol toxicity: the development of the toxic intermediate NAPQI once glucuronidation and sulfation pathways have been saturated.

Increases glutathione availability / sulfhydryl donor.

It may bind directly to NAPQI.

Question 2

Name an adverse effects of N-acetylcysteine

Answer 2

Flushing, rash, angioedema = mild anaphylactoid reaction.