Benztropine

Question 1

How does metoclopramide cause a dystonic reaction?

Answer 1

Metoclopramide is a dopamine antagonist. It causes an imbalance in the anticholinergic / dopamine transmission in the basal ganglia.

Question 2

You treat the dystonic reaction with benztropine. What is the mechanism of action of benztropine?

Answer 2

Benztropine blocks the muscarinic cholinergic receptors. It is an anti-cholinergic, anti-muscarinic.

Question 3

What are the potential side effects of benztropine?

Answer 3

Tachycardia, sedation, mydriasis, urinary retention, dry mouth.