Diuretics Flashcards by Heli Sinnpson | Brainscape

Q

How does frusemide exert its action?

A

Inhibits Na⁺/K⁺/2Cl^- transporter in the thick ascending loop of Henle.

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the pharmacokinetic properties of frusemide?

A

Rapid absorption after oral administration
Bioavailability approx 50%
Highly protein-bound
50% excreted in urine unchanged
Elimination half-life 1.5-2hrs
Peak effect 30mins IV / 1hr oral

(3 to pass)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly

Q

What are the potential adverse effects of frusemide?

A

Hypokalaemia
Hyponatraemia
Hypomagnesaemia
Hyperuricaemia
Postural hypotension
Allergy
Hyperglycamia

(bold + 2 to pass)

How well did you know this?

1

Not at all

2

3

4

5

Perfectly