Digoxin

Question 1

Describe how you would treat digoxin toxicity.

Answer 1

DigiFab or Digibind, which are immunoglobulins that bind digoxin and act as an antidote.
Treat hyperkalaemia.

Question 2

Describe some drugs that can reduce the clearance of digoxin, and the mechanism of how this happens.

Answer 2

Any drug that reduces GFR will reduce digoxin clearance (and also lithium clearance). e.g. NSAIDs (via the prostaglandin route), diuretics, ACE-inhibitors.
Verapamil reduces the clearance of digoxin.