Pharmacology Quiz 1 (Chapter 1-3) Flashcards
Drug definition
any chemical that affects living processes
Pharmacology
study of drugs and interactions with living things
Clinical Pharmacology
study of drugs in humans
Therapeutics
use of drugs to diagnose, prevent, or treat diseases or pregnancy
In a perfect world, What are the ideal functions of an ideal drug? (3)
*Effective
*Safe
*Selective
In a perfect world, what are the additional functions an ideal drug would have?
Reversible (null/metabolize)
Predictability
Ease of administering (convenient route/ low dose regimen, pt adherence, less risk)
Freedom drug interaction (no drug to drug interactions)
Low cost
Chemical stability with the same potency
Simple generic name
What is the ultimate goal of a therapeutic drug?
provide maximum benefits with minimum harm
A drug becomes toxic when given
too much of a dose
A drug becomes ineffective if given
too little of a dose
T/F
No 2 people respond the same to a drug.
True
What are the sources of individual variation?
Pharmacokinetics
Pharmacodynamics
What is the ultimate concern of administering a drug?
Intensity of response
Administration variations
poor patient adherence
Medication errors
Pharmacokinetics variations
absorption
distribution
metabolism
excretion
Pharmacokinetics definition
how drug moves through the body
Pharmacodynamics
how the drug affects the body
What determines the nature and intensity of the response?
pharmacodynamics
Nursing Process: Systematic approach
methodical
logical
orderly
What guides the nursing process decisions?
medication (stop med errors)
safety (pt care and education)
regulation
checks and balances
The prescribed dose:
Method and Errors
Administration
-Med errors (7 rights)
-Pt adherence
Concentration at the site:
Pharmacokinetics variation and errors
Pharmacokinetics
- absorption
- distribution
- metabolism
- excretion
AAPIE
(Pre) Assessment and Analysis
Planning
Implementation
Evaluation
Concentration at the site:
Pharmacodynamics variation and errors
- drug receptor
- pt functional state
- placebo effects
Concentration at the site:
Sources of variation and errors
- physiological
- pathological
(Pre) Assessment includes
-Baseline = history, physical exam, lab results, BP/VS, blood sugar, height, and weight
-High Risk = liver/kidney, impairment, genetic, allergies, pregnancy, elderly, pediatric
-Capacity for Self-care
Analysis includes
Nurse Diagnosis
- Judge: appropriate prescription drug regimen
- Identity: potential health problem that drug can cause
Planning includes
Establish objective criteria for evaluation
- define goals
- set priority
- ID specific intervention
Implementation includes
drug administration to education to intervention
- know when early signs, med response, manage toxicity
- therapeutic effects, minimize adverse effects and drug effects, make prn decision
Evaluation includes
therapeutic response
adverse drug reaction and interaction
What type of drug trials do drugs go through?
randomized control trial (volunteer or pt well-established)
randomization
blinding (single or double)
What trial is the best for accurate results?
double-blind (no one knows what med is given)
Stages of Drug Development
1- preclinical testing
2- clinical testing stage 1: healthy people tested on metabolism, pharmacokinetics, and biological effects
3- stage 2: therapeutic use and dose range
4- stage 3: safety and effectiveness
5- Post clinical: surveillance
After what stage does FDA give approval?
Stage 3
before post clinicals
Tylenol generic name
acetaminophen
Lithobid generic name
Lithium Carbonate
Toprol, Lopressor generic name
Metoprolol succinate
Label Requirements by Pure Food and Drug Act 1906
- plain, readable, user friendly
- active ingredient and inactive ingredients
- uses
- warnings
- directions
Educate pt on drug labels and approvals
OTC drugs are used for illness ___ % of the time.
60
Approximately how much money do OTC companies make each year?
30 billion
What percentage of drugs is initially self treated with OTC drugs?
60-90
What is the average number of OTC drugs in a household?
24
Clinical testing is not done on these individuals
women and children