Immunity/Reactivity Flashcards
Immunity def
physiologic process that provides an individual with protection or defense from disease
-responds to threats on an individualized basis
Acquired Immunity
produced by prior exposure or antibody production
Active and Passive Immunity
Innate Immunity
genetically determined - no prior exposure or antibody production involved
Natural flora immunity is under the
innate immunity
Active Immunity
produced by antibodies that develop in response to antigens
immune response
Natural or Induced
Passive Immunity
produced by transfer of antibodies from another person
Induced and Natural passive
Naturally Acquired Immunity
develops after exposure to antigens in environment
Induced active immunity
develops after the administration of antigens to prevent diseases
Vaccines are what type of immunity?
Active induced
Plasma and antibody transfer immunity to a specific disease given to someone what type of immunity?
Induced passive immunity
Induced passive immunity
conferred by the administration of antibodies to combat infection
Nutrition helps the immune system by
fighting infection and natural immunity in the body
-innate immunity
-anti-inflammation
-anti-aging
-anticancer
Natural passive immunity
conferred by transfer of maternal antibodies across placenta or in the breast milk
Attributes of Immunity
Normal WBC and differential counts
negative bacterial and viral cultures
soft, non-tender lymph nodes
recognition of self
recognition of foreign proteins
Malnutrition: Protein Risk Factors
psychological, social, and environmental
social isolation, grieving, finances, mistreatment, hospitalization, change in lifestyle
Malnutrition: Protein Risk Factors
Oral and dental disorders
poorly fitted dentures, mouth dryness, poor dental status, taste disorders, oral mucosa disorders
Malnutrition: Protein Risk Factors
Swallowing disorders
dysphagia
Malnutrition: Protein Risk Factors
Psychiatric disorders
eating and depressive disorders
Malnutrition: Protein Risk Factors
Change in mental status
confusion, stroke, paralysis
Malnutrition: Protein Risk Factors
Long-term drug therapy/polymedication
loss of appetite, dry mouth, drowsiness
Malnutrition: Protein Risk Factors
Acute/Chronic diseases
pain, constipation, disability
Malnutrition: Protein Risk Factors
Dependent of ADLs
need assistance with cooking, eating, mobility
Malnutrition: Protein Risk Factors
Restrictive Diets
physician order diets or slimming diet
Antigen
proteins that induce an immune response when they enter the body
Antigens are found in
microorganisms
vaccines
transplanted organs
allergens (animal dander, pollen, foods)
Inflammation
cellular response to injury, infection, or irritation
Localized Inflammation S/S
redness, swelling, heat, pain, loss of function
Systemic Inflammation S/S
fever, increase WBC, malaise, anorexia, nausea, vomiting, lymph node tenderness/enlargement, organ failure
Inflammatory Response
non-specific response to something that is harmful to the body ( infection, injury, or allergen)
_____________ plays a role in many chronic diseases.
Inflammation
Chronic response
-Cause of inflammation remains active
-Tissue destruction continues
-Scar tissue may continue to form rather than a normal functional tissue
-Response to infections is inadequate
-Patient experiences chronic symptoms (e.g., pain)
Allergic Response
hypersensitive immune reaction to a substance that is normally harmless or would not cause an immune response in everyone
-Mild to life-threatening
-Histamine released
-body produces antibodies to the substance
Factors increasing Host susceptibility infection
developmental
breaks in skin
illness, injury, chronic disease
smoking
substance abuse
multiple sex partners
environmental factors
invasive procedures
suppressed immune system/medications
Americans eat __% of toxic junk food with only __% to __% nutritious foods from fruits, veggies, grains, and legumes.
90%; 10-11%
Malnutrition
infections are frequent and chronic
Micronutrient deficiency affects innate and adaptive immune response
Micronutrients
iron
zinc
copper
selenium
vitamins
Stress on the immune system
Corticosteroids - stress hormone suppresses the immune system
-decreases T cells
Unhealthy coping strategies (drinking, smoking, insomnia)
Exercise on immune system
-increase t-cells
-lower levels of inflammation
-causes WBC to circulate more rapidly
-greater response to vaccines
-flushes out toxins from the body through sweat, urine, and respiratory tract
Older Adult Immune Systems
less able to distinguish self from nonself
macrophages destroy antigens more slowly
T-cells respond less quickly to antigens
WBC are fewer therefore the body is less stable to remember and defend itself
Antibodies become less able to attach to antigens
Decrease in thirst therefore an increase in UTIs
Nursing Interventions in Immunity
Nutrition
Hand hygiene
Immunization
Adequate rest and exercise
education
Antioxidant
protects against cell damage
Vitamins
A, B6, B12, C, D, E, Folate
Zinc, Iron, Copper, Selenium
Vitamin C
stimulates the production, function, and movement of leukocytes. Increases levels of antibodies
Vitamin D
limits inflammatory response promoted by specific T cell types.
Vitamin A
helps maintain the structural and functional integrity of mucosal cells in innate barriers
Vitamin E
antioxidant and protects the integrity of cell membranes. Enhances T cell functions and lymphocyte proliferation
Vitamin B6
Helps regulate inflammation. Has a role in antibody production
Vitamin B12
Facilitates production of T lymphocytes
Folate
maintains innate immunity and has roles in cell immunity
Zinc
maintains skin and mucosal membrane integrity. Central role in cellular growth and differentiation of immune cells.
Iron
Forms highly toxic hydroxyl radicals involved in killing bacteria. Important in proliferation of T lymphocytes
Copper
antimicrobial properties. Has roles in both T cell proliferation, antibody production and cellular immunity
Selenium
Involved in T lymphocyte proliferation, humoral system and immunoglobulin production.
The primary mediator of Type 1 hypersensitivity reaction is
Immunoglobulin E (IgE)
Allergy Type 1
-deleterious effects of hypersensitivity to exogenous antigens
-atopic-genetic predisposed
Most common allergies is
Type 1
Examples of Allergy Type 1
pollen, mold, fungi, foods, animals, dust, and almost anything we encounter in our environment
S/S of allergies
watery, runny eyes
runny nose
sneezing
nasal congestion
an itchy rash or hives
Anaphylaxis
-Immediate Type 1 hypersensitivity
-rapid release of IgE-mediated chemicals
-induces severe, life-threatening allergic reaction
-food, drug, and insect bites
Anaphylaxis Lung S/S
Trouble breathing or noisy breathing
Coughing, wheezing
Sneezing
Congestion
Tightness in lungs
Hoarseness
Anaphylaxis Skin S/S
Pale or flushed skin
Hives or Welts
Itchy skin
Sweating
Anaphylaxis Mouth S/S
Swelling of throat, face, lips, or tongue
Anaphylaxis Heart and Blood vessels S/S
Chest pain
Low blood pressure
Weak, rapid pulse
Dizziness, fainting
Anaphylaxis Stomach and digestion S/S
Abdominal pain
Nausea, vomiting
Diarrhea
IgE
reactions are mediated by antigen-specific IgE and the products of tissue mast cells
Treatment
1st - Epinephrine
Benadryl
EPI-Pen
dosage: 0.3 mg IM, one-time use
light-sensitive, keep in a storage tube
administer in thigh
~ Very Expensive ~
Epinephrine action
adrenergic response
Epinephrine Routes: SQ
Onset 5-10 mins
Peak 20 mins
Duration 1-4 hrs
Epinephrine Routes: IM
Onset 6-12 mins
Peak Unknown
Duration 1-4 hrs
Epinephrine Routes: IV
Onset rapid
Peak 20 mins
Duration 20-30 mins
Epinephrine for Anaphylactic Reaction
SQ, IM dosage and frequency
0.1-0.5mg (not to exceed 1mg); may repeat every 10-15 mins
Epinephrine for Anaphylactic Reaction
IV dosage and frequency
0.25mg every 5-15 mins, may be followed by 1-4mcg continuous infusion
Benadryl action
antagonizes the effects of histamine at the receptor site
Benadryl route - PO
Onset 15-60 mins
Peak 2-4 hrs
Duration 4-8 hrs
Benadryl route - IM
Onset 20-30 mins
Peak 2-4 hrs
Duration 4-8 hrs
Benadryl route - IV
Onset Rapid
Peak Unknown
Duration 4-8 hrs
Benadryl for Anaphylactic Reaction
PO dose and frequency
25-50mg every 4-6 hrs, not to exceed 300mg/ day
Benadryl for Anaphylactic Reaction
IM dose and frequency
25-50mg every 4 hrs, not to exceed 400mg/day
If both parents have a specific allergy, then the child has a _______ chance of getting it.
80% likely
If anaphylaxis is left untreated, what can it ultimately lead to?
Heart failure
Anaphylatic Reaction
rapid onset
dyspnea (tight throat, bronchospasm, laryngeal edema)
feeling of apprehension
tingling and swelling in mouth, face, throat, and tongue
itching
decrease bp
tachycardia
LOC