Pharma List B Flashcards
Which drug must be administrated with halothen
Atropine
Which drug can cause hernia among the iv anesthetics
Ketamine increasing ICP
Which opioids is used by gynecologist
Nalbupin - does not relax uterus
Which drug increases frequency of opening CL Channel
Benzodiazepines
Competitive antg of benzodiazepines
Flumazenil
Overs agonist of benzodiazepines
Beta carbolines
Hypnotic MOA of benzodiazepines
Bz2 receptor . Increase nREM decrease R.E.M. And nREM 3,4
Which benzodiazepines don’t have active metabolites
Oxazapam , temazapam , lorazepam
Which benzodiazepines used for absence seizure
Clonazepam
Temazapem indication
Useful in pt having difficulty to maintain sleep .
For panic attacks , Which benzodiazepines will u use
Alprazolam and clonazapam
How much of phenobarbital can cause narcosis
1g
Ultra short acting barbiturates
Thiopental methohexital
Which drugs bind BDZ1 receptor
Eszopiclone zolpidem zaleplone . Do not alter sleep stages .
Which drugs are given to pregnant woman with epilepsy
Barbiturates
Indication of zaleplon
Induction of sleep
Indication of ramelton
Sleep onset
Busiprone MOA
Pure anxiolytics by PA of 5HT1A . Indicated in generalized anxiety ( takes 3 weeks to function )
Disulfiram indication
Alcohol withdrawal by inhibiting acetaldehyde DH .
Partial d2 d3 antg
Cariprazine - also PA to 5HT1A
Pa d2 antagonist 5ht2a
Ariprazole
Which drug will u use enuresis
Imipramine by decreasing phase 4 of slow wave
Which antidepressant drug is also antipsychotic
Amoxapine - its metabolite
Unicyclic anti depressant
Bupropion
Describe seratonin syndrome
Hypertension tachycardia hyperreflexia tremor delirium
SSRI with longest DOA
Fluoxetine
Vilazodon MOA
Seratonin 1alpha partial agonist . Strong anxiolytic . Taken once a day .
Lowest protein binding among anti depressants.
Velnafaxin
Which serotonin receptor exhibits anxiolytic effect when blocked
5HT2c
Which drug treats depression due to alcohol withdrawal
Tianeptin ( effects CRH axis )
Drug from antidepressants indicated for ADHD
Atomexetin
MOA of lithium
Increase Gi decrease Gs , similar to na thus enters cells and depolarizes them , decrease PIP2
Toxic plasma level of lithium
1.5-1.7 mol/ liter
Which diuretics help excretion of lithium
Amiloride
Mood stabilizers
Lithium , carbamazepine , valproate , lamotrogine
Anticonvulsants drug in pregnancy
Gabapentin
SE of phenytoin
Hirsutism , gingival hyperplasia, osteomalacia, cardiac arrythmogenic, strong enzyme inducer ( don’t use oral contraceptives)
MOA of Gabapntin
Inhibit n type Ca channel — decrease glutamate
Indications of gabapentin
Mood stabilizer, neuropathic pain , central muscle relaxant , seizure
MOA of vigabetrin
Irreversible inhibitor of gaba aminotransferse
Which anti epileptic is working on AMPA
Topiramate , lemotragine
Which diazepam used for absence seizures
Clonazapam
Drugs for absence seizures
Ethusoximide , trimethadion ( old version ) , clonazapam , valproic acid
Promadone MOA
Metabolites PEMA and barbiturates block Na channel and potentiate Gaba
Levatiracetam MOA
Modifies gaba and glutamate release
SE : aggressive behavior
Why ergot derivatives are less used in Parkinson’s
Massive dyskinesia .
Amantadine MOA
Blocks muscarinic receptors and enhances dopamin . Also inhibits adenosine A2 — disinhibition of D2 mediated effects
When to use anticholinergic drugs in Parkinson
In tremor dominant and drug induced Parkinson
Which antipsychotic is given in Parkinson
Clozapine
Who is the only local anesthetics that does not need vasoconstrictor
Cocain - sympathomimetic
Fastest acting local anesthetics
Articain ?
Which anti histamine eliminated from kidney unchanged
Cetirizine ,acrivastin
Which drug combo with anti histamine can cause severe arrhythmias
Itraconaxol ketoconazol microlids
What is the dose for antithrombosis effect of aspirin
75-100 mg
Non acidic NSAIDS
Nebumatone
Which NSAIDS is sulfa drug
Celecoxib
Cincalcet MOA
Activate ca sensing receptor and inhibit PTH
Name estrogen receptor antg
Fluvestrant
17 alpha hydroxilase inhibitors
Abirateon