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Low Yield Semmelweis > Pharma List B > Flashcards

Pharma List B Flashcards

1
Q

Which drug must be administrated with halothen

A

Atropine

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2
Q

Which drug can cause hernia among the iv anesthetics

A

Ketamine increasing ICP

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3
Q

Which opioids is used by gynecologist

A

Nalbupin - does not relax uterus

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4
Q

Which drug increases frequency of opening CL Channel

A

Benzodiazepines

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5
Q

Competitive antg of benzodiazepines

A

Flumazenil

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6
Q

Overs agonist of benzodiazepines

A

Beta carbolines

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7
Q

Hypnotic MOA of benzodiazepines

A

Bz2 receptor . Increase nREM decrease R.E.M. And nREM 3,4

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8
Q

Which benzodiazepines don’t have active metabolites

A

Oxazapam , temazapam , lorazepam

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9
Q

Which benzodiazepines used for absence seizure

A

Clonazepam

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10
Q

Temazapem indication

A

Useful in pt having difficulty to maintain sleep .

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11
Q

For panic attacks , Which benzodiazepines will u use

A

Alprazolam and clonazapam

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12
Q

How much of phenobarbital can cause narcosis

A

1g

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13
Q

Ultra short acting barbiturates

A

Thiopental methohexital

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14
Q

Which drugs bind BDZ1 receptor

A

Eszopiclone zolpidem zaleplone . Do not alter sleep stages .

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15
Q

Which drugs are given to pregnant woman with epilepsy

A

Barbiturates

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16
Q

Indication of zaleplon

A

Induction of sleep

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17
Q

Indication of ramelton

A

Sleep onset

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18
Q

Busiprone MOA

A

Pure anxiolytics by PA of 5HT1A . Indicated in generalized anxiety ( takes 3 weeks to function )

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19
Q

Disulfiram indication

A

Alcohol withdrawal by inhibiting acetaldehyde DH .

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20
Q

Partial d2 d3 antg

A

Cariprazine - also PA to 5HT1A

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21
Q

Pa d2 antagonist 5ht2a

A

Ariprazole

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22
Q

Which drug will u use enuresis

A

Imipramine by decreasing phase 4 of slow wave

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23
Q

Which antidepressant drug is also antipsychotic

A

Amoxapine - its metabolite

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24
Q

Unicyclic anti depressant

A

Bupropion

25
Q

Describe seratonin syndrome

A

Hypertension tachycardia hyperreflexia tremor delirium

26
Q

SSRI with longest DOA

A

Fluoxetine

27
Q

Vilazodon MOA

A

Seratonin 1alpha partial agonist . Strong anxiolytic . Taken once a day .

28
Q

Lowest protein binding among anti depressants.

A

Velnafaxin

29
Q

Which serotonin receptor exhibits anxiolytic effect when blocked

A

5HT2c

30
Q

Which drug treats depression due to alcohol withdrawal

A

Tianeptin ( effects CRH axis )

31
Q

Drug from antidepressants indicated for ADHD

A

Atomexetin

32
Q

MOA of lithium

A

Increase Gi decrease Gs , similar to na thus enters cells and depolarizes them , decrease PIP2

33
Q

Toxic plasma level of lithium

A

1.5-1.7 mol/ liter

34
Q

Which diuretics help excretion of lithium

A

Amiloride

35
Q

Mood stabilizers

A

Lithium , carbamazepine , valproate , lamotrogine

36
Q

Anticonvulsants drug in pregnancy

A

Gabapentin

37
Q

SE of phenytoin

A

Hirsutism , gingival hyperplasia, osteomalacia, cardiac arrythmogenic, strong enzyme inducer ( don’t use oral contraceptives)

38
Q

MOA of Gabapntin

A

Inhibit n type Ca channel — decrease glutamate

39
Q

Indications of gabapentin

A

Mood stabilizer, neuropathic pain , central muscle relaxant , seizure

40
Q

MOA of vigabetrin

A

Irreversible inhibitor of gaba aminotransferse

41
Q

Which anti epileptic is working on AMPA

A

Topiramate , lemotragine

42
Q

Which diazepam used for absence seizures

A

Clonazapam

43
Q

Drugs for absence seizures

A

Ethusoximide , trimethadion ( old version ) , clonazapam , valproic acid

44
Q

Promadone MOA

A

Metabolites PEMA and barbiturates block Na channel and potentiate Gaba

45
Q

Levatiracetam MOA

A

Modifies gaba and glutamate release

SE : aggressive behavior

46
Q

Why ergot derivatives are less used in Parkinson’s

A

Massive dyskinesia .

47
Q

Amantadine MOA

A

Blocks muscarinic receptors and enhances dopamin . Also inhibits adenosine A2 — disinhibition of D2 mediated effects

48
Q

When to use anticholinergic drugs in Parkinson

A

In tremor dominant and drug induced Parkinson

49
Q

Which antipsychotic is given in Parkinson

A

Clozapine

50
Q

Who is the only local anesthetics that does not need vasoconstrictor

A

Cocain - sympathomimetic

51
Q

Fastest acting local anesthetics

A

Articain ?

52
Q

Which anti histamine eliminated from kidney unchanged

A

Cetirizine ,acrivastin

53
Q

Which drug combo with anti histamine can cause severe arrhythmias

A

Itraconaxol ketoconazol microlids

54
Q

What is the dose for antithrombosis effect of aspirin

A

75-100 mg

55
Q

Non acidic NSAIDS

A

Nebumatone

56
Q

Which NSAIDS is sulfa drug

A

Celecoxib

57
Q

Cincalcet MOA

A

Activate ca sensing receptor and inhibit PTH

58
Q

Name estrogen receptor antg

A

Fluvestrant

59
Q

17 alpha hydroxilase inhibitors

A

Abirateon

Low Yield Semmelweis (37 decks)

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