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Low Yield Semmelweis > Immuno Practice Questions (Midterm Week 9) > Flashcards

Immuno Practice Questions (Midterm Week 9) Flashcards

1
Q

Main functions of basophil granulocytes

A synthesis of complements

B phagocytosis and synthesis of complementes

C phagocytosis

D histamine production

E same as the function of eosinophil ones

A

histamine production

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2
Q

The afferent lymph vessles in spleen are:

A)Site of Entrance of the naive lymphocytes

B)Site of entrance of commited lymphocytes

C)Site of the entrance of commited lymphocytes

D)There are no afferent lymph vessels in the spleen

A

There are NO afferent lymph vessels in the spleen

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3
Q

IFN-gamma is characterized by:

A) Activation of macrophages

B) growth signaling for T cells

C) Induction of IgA expression on B cells

D) Produced by CTL

A

Activation of macrophages

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4
Q

Extravasation of lymphocytes

A cells avoid HEV

B process through the nuclear membrane helped by selectins and lectins

C process helped by diverse adhesive proteins

D integrins, CD44 and T cell receptors cooperate in it

A

process helped by diverse adhesive proteins

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5
Q

Which one is FALSE?

A)TCR interacts with MHC/pepride is weak

B)TCR interaction is stabilized by accessory molecules

C)Peripheral T cells can express both CD4 and CD8

D)CD4+ T cells are helper T cells

A

Peripheral T cells can express EITHER CD4 or CD8

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6
Q

Dendritic cells express:(2)

A)MHC II and B7

B)MHC I but not B7

C)MHC II but not B7

D)MHC II and MHC I

A

MHC II and B7

MHC II and MHC I

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7
Q

They are absolute indications for flow cytometry, except:

A)Bacterial Infection

B)Leukemia

C)Multidrug resistant

D)AIDS

A

Bacterial Infection

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8
Q

Cytokine of Th1 character

A IFN a

B IFN b

C IFN g

D IFN w

A

IFN g

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9
Q

Which of these Molecules are found on each of these cells? (MCQ)

  • Molecules : Fas-L, CTLA4, TGF-βR, CD5
  • Cells: B cells, TH17, Cytotoxic T cell
A

B cells - CD5 and TGF-βR

TH17 - TGF-βR

Cytotoxic T cell - Fas-L, CTLA4

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10
Q

Antibodies form a complex in which type of hypersensitivity:

a. I
b. II
c. III
d. Iv

A

III

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11
Q

Which one of the following cell types would be least likely to participate in an inflammatory response?

A) Mast cells

B) Neutrophills

C)Dendritic cells

D)Natural Killer cells

A

Natural Killer cells

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12
Q

A given macrophage producing IL8 can induce cells in the brain to rerset the body thermostat to a higher temprature. This represents ___ action of a cytokine.

A)Autocrine

B)Endocrine

C)Paracrine

D)Orthocrine

A

Endocrine

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13
Q

What statment is FALSE?

A)Precipitate is not formed in the excess of the antigen

B)Orecipitate is not formed in the excess of the Antibody

C)Immune complex is not formed in the equivalvance zone

D)Excess antigen doesnt favour agglutination

A

Immune complex DO form in the equivalvance zone

(C)

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14
Q

Case of MHC incompatibility

A Anti-D antibody is given to avoid complications

B has importance only in bone marrow transplantation

C immunological rejection follows

D T cells die by programmed cell death

A

immunological rejection follows

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15
Q

A receptor which DOES’NT play an importnat role in the endocytosis or phagocytosis is:

A)TCR

B)BCR

C)FcR

D)Complement receptor

A

TCR

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16
Q

They have a role during homing:

A)TCR

B)BCR

C)ICAM and CD4

D)Selectins and Integrins

A

Selectins and Integrins

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17
Q

Binding of MBL to mannose on an antigen suface:

A)Inactivates the complements cascade

B)activates T cell proliferation

C)Directly causes the release of Histamines

D)Is an example for pattern recognition

A

Is an example for pattern recognition

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18
Q

What is NOT a characteristic of the T independent antigns:

A) Bacterial Flagelin

B)Haptens

C)Antigens containing repeating sequences

D)Compount capable of cross-linking BcR

A

Haptens

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19
Q

Chemotactic substance

A IL-6

B IL-7

C IL-8

D IL-9

E IL-4

A

IL-8

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20
Q

Inflammation and Immune activation generate symptoms similar to a psychiatric disease. which one?

A)Schizophrenia

B)Hyperactivity

C)Depression

D)Dyslexia

A

Depression

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21
Q

Which of the following contribuits to the estabishment of TH2 cell fate?

A)GATA-3

B)T-Bet

C)FoxP3

D)IL-4

E)IFN-Gamma Receptor

A

GATA-3

IL-4

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22
Q

Antigen Recognition of B cells:

A)They “see” the native conformation

B)They “see” 13-30 amino acid long peptides

C)They “see” 8-9 amino acid long peptides

D)They “see” MHC II /Peptide complex

A

They “see” the native conformation

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23
Q

Which of the following is thrue regarding MHC Class I molecules?

A)Multiple types of MHC class I molecules can be expressed on a given cell

B)Each MHC Class I molecule binds to its own specific cognate antigen protein

C)MHC Class I molecules can bind their antigen peptides more tightly than antibodies

D)MHC Class I molecules can be expressed only on professional APCs

A

Multiple types of MHC class I molecules can be expressed on a given cell

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24
Q

Ig-Alpha Chain is:

A)Heavy chain of IgG

B)Heavy chain of IgM

C)Heavy chain of IgA

D)Signal transducer

A

Signal transducer

(BCR - CD79B)

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25
Q

Serum Electrophoresis - Normal

What is the meaning of Each peak?

A

Alb-Albumin

α1 Globulins- Antitrypsin, SAA

α2 -Macroglobulin, Ceruloplasmin

β - Microglobulin, Plasminogen, Transferrin

γ - Immunoglobuins

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26
Q

Which satment is true for the CH50 test?

A)Provides information only about C1,C2,C3,C4

B)Its value is identical to the denominator of the serum dilution that lyses 50% of antibody coated Sheep RBCs

C)Provides data about the concentration of members of the alternative complement activation patheays

D)Measures the concentration of the members in the MBL pathway

A

Its value is identical to the denominator of the serum dilution that lyses 50% of antibody coated Sheep RBCs

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27
Q

The role of antibodies in the immune response to tumors:

A in most cases they inhibit the effective immune response

B in all cases they promote the effective immune response

C by inactivating complements they promote the effective immune response

D they inhibit NK cells

A

in most cases they inhibit the effective immune response

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28
Q

Which statements is valid for HEV-s?

A they are found in all immune organ

B they are special postcapillary venules found permanently in lymph nodes and GALT

C tissue lymphocytes enter the circulation through their wall

D lymphocytes quit circulation and enter the red pulp through their wall

A

tissue lymphocytes enter the circulation through their wall

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29
Q

Cell Mediated Immunity Involves:

A)Specific B-cells are activated to make IgA

B)Effector T-cells are cytotoxic CD8+ T cells

C)Antigens are presented by MHC class II

D)TH2 helper CD4+ cells activate CTLs

A

Effector T-cells are cytotoxic CD8+ T cells

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30
Q

Main costimulatory effect of B cell activation

A)CD28-B7

B)CD28-ICAM

C)MHC activation

D)CD40-CD40L

A

CD40-CD40L

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31
Q

Class II antigens present antigen peptides that have been :

A)Digested by passing them through a proteasome

B)Transported through the endoplasmic reticulum by TAP1/TAP2

C)Loaded onto MHC by replacing CLIP

D)Folded correctly by Calnexin

A

Class II antigens present antigen peptides that have been Loaded onto MHC by replacing CLIP

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32
Q

Genetic background of MHC polymorphism

A several polymorphic sites in the introns

B several polymorphic sites in the exons

C no introns in the genes

D genetic rearrangement in the bone marrow

A

several polymorphic sites in the exons i.e. Alleles

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33
Q

Role of fetal liver:

A Excretion.

B Source of fetal immunoglobulins

C Source of bone marrow stem cell

D Same as in the adult liver

A

Source of bone marrow stem cell

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34
Q

A cell surface marker generally typical for T cell is:

A)CD3

B)CD40

C)CD44

D)CD7

A

CD3

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35
Q

Marginal Zone B cells:

A) Are part of the innate immune response

B) Recognize carbohydrate antigens

C) Secrete IgG

D)Form a first line of defence in the body surfaces

A

Recognize carbohydrate antigens

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36
Q

Where in lymph nodes are T cells found?
a. paracortex

b. cortex
c. medulla
d. germinal cemter

A

paracortex

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37
Q

The place of affinity maturation:

A Bone marrow

B Thymus

C Embryonic liver cell

D Periphery

A

Periphery

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38
Q

Role of IL6 in B cell maturation

A costimulation

B improving MHC expression

C activation of Th1 cells

D terminal differentiation in B cell maturation to plasma cell

A

terminal differentiation in B cell maturation to plasma cell

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39
Q

What does the decrease in C3 and C4b proteins serum level refer to?

A)Alternative complement activation

B)Activation of the most ancient complement pathway

C)Classical complement activation

D)Lack of complements

A

Classical complement activation

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40
Q

B cells are capable for antigen presentation since:

A)they posses a MHCII

B)They are CD3+

C)They select reactive NK cells

D)They differintiate into plasma cells

A

they posses a MHCII

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41
Q

MHC II is not Expressed on:

A)Cytotoxic T cells

B)B cells

C)Dendritic Cells

D)Macrophages

A

Cytotoxic T cells

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42
Q

It elevates permeability and has chemotactic activity:

A C1q

B C2

C C3

D C3a

E C3b

A

C3a

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43
Q

Myeloperoxidase is acting in this kind of cells:

A neutrophilic granulocyte

B macrophage

C eosinophilic granulocyte

D B cell

A

neutrophilic granulocyte

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44
Q

When the innate immune system encounters a foreign antigen, what cell-surface molecule plays the role of recognizing the presence of the foreign antigen?

A) TCR

B) MAC

C)TLR

D)HLA class II

A

TLR

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45
Q

Cytokine receptors are characterized

A with high affinity and in small number

B with high affinity and in great number

C with low affinity and in small number

D with low affinity and in great number

E belonging to the integrin super family

A

with high affinity and in small number

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46
Q

Naive CD4+ T cells:

A)Are also called Cytotoxic T cells

B)Respond to IL1 and IL12 to become TH1 cells

C)Respond to Antigen presented by HLA type I

D)are stimulated to rearrange the DNA for their TCR in the Bone Marrow

A

Respond to IL1 and IL12 to become TH1 cells

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47
Q

Not reffred to as proffesional APCs:

A)B cells

B)T cells

C)Monocyte

D)Macrophages

A

T cells

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48
Q

Diversity of the TCR is increased by:

A)Binding to different MHC receptors.

B)Somatic cell mutations after T cell activation.

C)Addition of N Nucleutides at the recombination junction sites.

D)Rearranging both beta chains of the TCR at the same time.

A

Addition of N Nucleutides at the recombination junction sites.

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49
Q

CD antigens are

A differentiation antigens

B substances with no biological function

C non-self antigens

D found exclusively on mature lymphocytes

E complement determination factor

A

differentiation antigens

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50
Q

Serum Electrophoresis - Condition?

A

Monoclonal Gammaopathy - M spike

Examples: Multiple Myeloma/MGUS

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51
Q

Cell lines are:

A) Cultures of cells always from tumors

B)Cultures of cells always from healthy organs

C)always containing transformed cells

A

always containing transformed cells

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52
Q

IgG mediated pathological process:

A 1. type hypersensitivity reaction

B 2. type hypersensitivity reaction

C 3. type hypersensitivity reaction

D 4. type hypersensitivity reaction

E 5. type hypersensitivity reaction

A
  1. type hypersensitivity reaction
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53
Q

The immunoglobulin classes found on B cell surfaces in the beginning of maturation

AIgM and IgD

B IgG or IgE

C IgG

D either of the immunoglobulins

E IgE

A

IgM and IgD

54
Q

What is the ending of the names of Human Antibodies?

A)XIMAB

B)ZUMAB

C)CICPET

D)UMAB

A

UMAB

55
Q

Members of the classical pathway of complement activation:

A)C1b,C2b,C3b

B)C2b,C3b,Bb

C)C3b,C4b,D

D)C2b,C3b,C4b

A

C2b,C3b,C4b

56
Q

Two antibodies that have the same antigenic recognition sequence are called:

A)Isotypes

B)Allotypes

C)Idiotypes

D)Autotypes

A

Idiotypes

57
Q

TAP Complex is responsible for the transport of :

A)10 Residue lone Peptides

B)20 residue Long Peptides

C)Derivatives of enzymic degredation to the golgi

D)derivatives of enzyimic degredation to lysosomes

A

10 Residue lone Peptides

58
Q

Which statement is FALSE for Immunoglobulin fold domain?

A)It is a loop like structure first described in immunoglobulin molecules

B) It is also found in TCRs

C) It is also a structural element of MHCs

D)It is formed by two beta-Sheets connected by disulfide bonds

A

It is NOT a loop like structure first described in immunoglobulin molecules

59
Q

Aim of Acute phase reaction:

A)Seperation of infected cells

B)Balancing the homeostasis

C)Eradication of necrotix tissue

D)Initiation of Regeneration

A

Balancing the homeostasis

60
Q

If the levels of both C3 and C4b complement proteins decreased in the circulation if refers:

A) the alternative complement activation

B)the activation of the most ancient activation pathway

C)Classical Complement Activation

D)Lack of Complement

A

Classical Complement Activation

61
Q

TH1 Cytokines are:

A)IL1, IL5, IL3

B)IL2, IL12, IFN-Gamma

C)IL2, IL4, IFN-Gamma

D)IL12, IL10, TGF-Beta

A

IL2, IL12, IFN-Gamma

62
Q

What is the ending of the names of Humanized Antibodies?

A)XIMAB

B)ZUMAB

C)CICPET

D)OMAB

A

ZUMAB

63
Q

. Ligands for Fcg receptors

A N terminus of IgG

B C terminus of IgG

C C terminus of IgM

D C terminus of immunoglobulin light chain

E N terminus of kappa chain

A

C terminus of IgG

64
Q

Biological roles of the complement system

A antibody production against bacteria

B cellular immunity against bacteria

C lysis of bacteria

D inhibition of bacterial multiplication

E inhibition of viral multiplication

A

lysis of bacteria

65
Q

PAMP-PPR Interactions:

A)Induce IL1,IL8 and TNF production

B)Induce IL6 production

C) Activate the complement system via classical path.

D)Activate acute phase reaction through the induction of Stress hormones

A

Induce IL1,IL8 and TNF production

66
Q

What it the complementarity determining region?

A)Structure recognized by Antibodies

B)Variable region with antigen binding capacity

C)3 short sequences determinig the heterogenecity of the variable region which are complementary to single epitope of the antigen to be recognized

D)10-10 amino acid long parts of Antibodies

A

3 short sequences determinig the heterogenecity of the variable region which are complementary to single epitope of the antigen to be recognized

67
Q

Secondary immune organs are for:

A antigen recognition and activation of lymphocytes

B distinction between self and non-self

C the assembly of antigen recognizing lymphocytes

D antigen presentation

A

antigen recognition and activation of lymphocytes

68
Q

Which part of the IgE antibody is responsible for binding to mast cells and basophills?

A)Light chain

B)Fc region

C)CDR

D)Complement binding site

A

Fc region

69
Q

Identify the TRUE Statement about MHC molecules:

A)T cells can recognize antigen bound to either self or non-self MHC

B)MHC Class II is composed of one unique aloha chain and the common Beta2 Microglobulin chain

C)MHC Class II is recognized by CD4+ T cells.

D)MHC Class I has the primary role of recognition of self-peptides

A

MHC Class II is recognized by CD4+ T cells.

70
Q

. Bacteria are recognized by lectins through

A cell wall peptides

B complement factors

C carbohydrates

D Fc portion of the binding immunoglobulins

A

carbohydrates (E.g. MBL)

71
Q

Superantigens :

A)Bind in the antigen-binding cleft of the MHC Class I

B)bind in the antigen-cleft of the MHC Class II

C)Bind to non antigen-specific regions of MHC and TCR

D)Trigger clonal Anergy

A

Bind to non antigen-specific regions of MHC and TCR

72
Q

Serum Electrophoresis - Condition?

A

Serum Electrophoresis - Polyclonal Gammopathies

Example: Hyper-IgM Immunodeficiency

73
Q

Mutual inhibitiors:

A IFNg and TNFa

B IFNg and MHC expression

C IFNg and IL-4

D IL-4 and IgE

A

IFNg and IL-4

74
Q

The location of MHC in the genome

A regulated by oncogenes

B changes with phylogeny

C became fixed in phylogeny

D X or Y chromosome may contain

A

became fixed in phylogeny

75
Q

Which parameter of the cells is obtained in the SSC (Side scatter) data of a flow cytometric mesearment?

A)The relative size of the cells

B)Ratio of live/dead cells

C)The number of cell-cell interactions

D)The relative granularity of the cells

A

The relative granularity of the cells

(Part of the internal complexity given by SSC)

76
Q

T cells maturation is driven by the ____ protein that is expressed by stromal cells in the thymus.

A)Zeta part of CD3

B)CD44

C)IL2

D)Notch

A

T cells maturation is driven by the Notch protein that is expressed by stromal cells in the thymus.

77
Q

Which statement is true regarding cell counting?

A)Burker chamber counts the number of cells based on impedence changes

B)There is no means of estmating cell concentrations accuratly by using microscope

C)FACS is able to count total cell numbers, as well as the number of cells that belong to given cell type

D)Trypan blue staining helps to identify dead cells in a flow cytometer

A

FACS is able to count total cell numbers, as well as the number of cells that belong to given cell type

78
Q

Complement genes in the MHC III region

A C1, C2, C3

B C2, C3, C4

C C2, C3, B

D C2, C4, B

A

C2, C4, B

79
Q 
Which statment is FALSE for PRRs?
A)Major class include LPS receptor, Toll receptor and Complement.

B)They predominantly recognize carbohydrate,lipid and sialic acid moecules on microbial surfaces

C)PAMPs that are recognized by the receptors induce B7 expession by APCs

D)They provide some specificity in the natural immune response

A

They predominantly recognize carbohydrate,lipid and sialic acid moecules on microbial surfaces.

sialic acid - Receptor is not a PRR! it is Influenza virus mechanism of action

80
Q

It has IgE binding capacity

A FCg receptors

B FCa receptors

C CD23

D CD44

E CD1

A

CD23 - A.K.A FceRII

81
Q

Effective defense mechanisms against tumor cells

A complement

B antibody and complement

C Th cells

D T cytotoxic and NK cells

A

T cytotoxic and NK cells

82
Q

CD34 is a marker of:

A) T cells

B) B cells

C) Granulocyte

D) Hematopoietc Stem Cell

A

Hematopoietc Stem Cell

83
Q

Which receptor doesnt play a role in phagocytosis?

A)TCR

B)BCR

C)FcR

D)Mannose receptor

A

TCR

84
Q

Size of the peptide in MHC II

A random

B approx. 10-24 amino acids

C 9-10 amino acids

D 3-4 amino acids

A

approx. 10-24 amino acids

85
Q

What is the ending of the names of Chimeric Antibodies?

A)XIMAB

B)ZUMAB

C)CICPET

D)MUMAB

A

XIMAB

86
Q

Inhibits the humoral Immune response:

A)IL2

B)IL3

C)IL4

D)IL12

A

IL4

87
Q

Fc receptors

A soluble proteins

B autoantibodies

C membrane receptors interacting with MHC

D membrane receptors interacting with IgG Fc region

A

membrane receptors interacting with IgG Fc region

88
Q

Which of the following is an endogenous pyrogen invovled in the production of Acute Phase Reaction?

A)IL1

B)IL2

C)IL4

D)IL6

A

IL6

89
Q

Which hepatic acute phase protein gene expression is elevated during the inflammation to the largest degree:

A)Fibrinogen

B)Albumin

C)Haptoglobin

D)CRP

A

CRP

90
Q

From the serum of our patient the results of ELISA carried out to determine the autoantibody level were the following (492nm):

What is the titer of the given autoantibody?

A)1:100 - OD Value 0.86

B)1:400 - OD Value 0.52

C)1:800 - OD Value 0.28

D)1:3,200 - OD Value 0.01

A

1:800 - OD Value 0.28

91
Q

The essence of subunit vaccine is:

A)to form a more efficient subunit of the antibody during immune response

B)to prevent the formation of the inflmammatory subunit of the antibody during immune response

C)that not a whole pathogen is used for immunization

D)that the activation of the complement system becomes efficient

A

That not a whole pathogen is used for immunization

92
Q

What kind of chemical bond can NOT form between Ag and Ab?

A)Hydrogen

B)Covalent

C)Ionic

D)Hydrophobic

A

Covalent

93
Q

Identify the TRUE statement about TCR on αβ T cells:

A) The T cell receptor is composed of a common α subunit and a unique β unit.

B) The β subunit of the TCR is the product of reaaranged V, D and J segments that are combined with a constant region.

C) The TCR has a signal trunsduction region on its cytoplasmic side.

D)The TCR on a given T cell will recognize all MHCs

A

The β subunit of the TCR is the product of reaaranged V, D and J segments that are combined with a constant region.

94
Q

Immune reactions are sensitive since

A they are carried about by activated cells

B activated cells and antibodies contribute to them

C amplifying mechanisms operate in immune activations

D inborn reactions serve for them

A

amplifying mechanisms operate in immune activations

95
Q

Serum Electrophoresis - Condition?

A

Chronic Liver Failure

Relative Gamma Elvation -Decrease in rest of proteins

96
Q

Antigens are

A non-self substances

B substances of protein character

C substances eliminated by the organism

D substances provoking immune reactions

E substance recognized by PRRs

A

substances provoking immune reactions

97
Q

Serum Electrophoresis - Condition?

A

Chronic Inflamation

Examples:AIDS/Subacute Bacterial Infection/SLE

98
Q

Antibodies in the organism

A in blood plasma and in lymph

B in blood plasma, in lymph, on B and T cell surfaces

C in blood plasma, in lymph, on T cell surfaces

D in blood plasma, in lymph, on B cell surfaces

A

in blood plasma, in lymph, on B cell surfaces

99
Q

Not a Member of VDJ recombinase Enzyme complex:

A)RAG1

B)TdT

C)FoxP3

D)Artemis

A

FoxP3

100
Q

Selection theory:

A)Antigen selectively generates T and B cell receptors

B)Selection works at the bone marrow level

C)Antigen generates the antigen receptors

D)Antigen selects from T and B cells pool

A

Antigen selects from T and B cells pool

101
Q

CXC chemokines can be produces by :

A)Epithelial cells

B)Fibroblast

C)Lymphocytes

D)Microglia

A

Epithelial cells

102
Q

Defense mechanisms against soluble bacterial toxins

A interferons

B antibodies

C T cytotoxic lymphocytes

D NK cells

E keratinocytes

A

antibodies

103
Q

Cytokines are pleiotropic since

A they act in concert with other cytokines

B they have different functions

C they are specific for the antigen

D they are not specific for the antigen

A

they have different functions

104
Q

It is NOT associated with the somatic hypermutation:

A)Generation of new antibody variants.

B)Class switch

C)Affinity maturation

D)DNA repair

E)Formation of new MHC allele

A

Formation of new MHC allele

105
Q

The process of phagocytosis is directly NOT involved in

A antibody synthesis

B elimination

C antigen presentation

D inflammation

A

Antibody synthesis

106
Q

During the TH1 response:

A)Cell mediated immune response is decreased, the humoral immue response is increased

B)Both the cellular and Humeral immune response are increased

C)humoral immune response is decreased, the humoral Cell mediated immue response is increased

D)Hypermutation is decreased

A

Both the cellular and Humeral immune response are increased

107
Q

Which of the following pairs of Cytokines and Cells will cause chemoattractant response? (2)

A)Eotaxin (CCL subtype) - B cell

B)RANTES (CCL5) - Monocyte

C)Fractalkine (CX3CL1) - Monocyte

D)Lymphotactin (XCL1) - Endothel

E)IL8 - Neutrophil

A

Fractalkine (CX3CL1) - Monocyte

IL8 - Neutrophil

(Eotaxin CCLs are Not affecting B cells)

(CCL5 is for other WBCs NOT monocytes)

108
Q

Which molecules are NOT encoded in the MHC class II region?

A)HLA-DR

B)HLA-DM

C)HLA-DQ

D)HLA-A

A

HLA-A

109
Q

MHC “mimicri” is

A an effective protection against autoimmune diseases

B favoring infectious diseases

C observed in case of MHC II

D observed in case of MHC I

A

favoring infectious diseases

110
Q

Antibodies to sterptococcus pygenes attack certain proteins in the heart valves, causing rheumatic fever. this is an example of:

A)An autoimmune disease

B)Cross-reactivity

C)Passive immunization

D)Neutralization of Antigens

A

Cross-reactivity

(caused by molecular mimicry)

111
Q

CD59:

A)Is espressed on bacterial surfaces

B)Inhhibits the interaction of C8 and C9 thus protects from creation of pore complex

C)Increases the efficiency of the membrane attack complex

D)Induces ITAM phosphorylation

A

Inhhibits the interaction of C8 and C9 thus protects from creation of pore complex

112
Q

The ability of several different cytokines to exert a similar activity is called ___.

A)Redundancy

B)Pleiotropy

C)Additivity

D)Synergism

A

Redundancy

113
Q

In the direct agglutination test, ___ .

A)Antibody serves as the index molecule.

B)RBC’s serve as the indicator

C)Rh factor serves as the indicator

D)Fluorescence antibody serves as the agent detected

A

RBC’s serve as the indicator

114
Q

Identify the cytokine that is responsible for early development of B cells in the bone marrow. In its abscence, B cell do NOT develop.

A)IL1

B)IL2

C)IL4

D)IL7

A

IL7

115
Q

Which of the following procedures allows the identification and collection of a particular type of cell that has been recognized by labeled antibody?

A)Westren blot

B)Electrophoresis

C)Fluorescence-activated cell sorting

D)Immunofluorescence

A

Fluorescence-activated cell sorting

116
Q

What is observed during microtoxicity test?

A)Degredation of cells belonging to the questioned HLA-group

B)Flouresence signal intensity of lablled antibodies in immune complexes

C)Sheep RBCs lysis

D)Enzymatic based detection

A

Degredation of cells belonging to the questioned HLA-group

117
Q

IgE class switch by which cytokines:

  1. IL2
  2. IL4
  3. IL6
  4. IL8
A

IL4

118
Q

A non-local process

A complement activation

B platelet aggregation

C chemotaxis

D acute phase reaction

E graft versus host reaction

A

acute phase reaction

119
Q

B lymphocyte entering the lymph node dies if

A it is reached by antigen

B it is not reached by antigen

C it does not recognize self MHC

D it reacts with self MHC IT HAPPENS BONE MARROW

E In both case of C and D

A

it is not reached by antigen

120
Q

Cell movement along gradients formed on biological surfaces is:

A)Chemotaxis

B)Necrotaxis

C)Chemokinesis

D)Haptotaxis

A

Haptotaxis

121
Q

The appearance of TCR without CD3:

A on T memory cells

B in T cell maturation in the bone marrow

C never

D TCR is never in complex with CD3

A

never

122
Q

The part of an antigen that is recognized by the adaptive immune system is calld:

A)an Epitope

B)an Isotype

C)Cytokine

D)Chemokine

A

an Epitope

123
Q

ELISA is applicable in the following cases:

A)Determination of complement factors

B)Determination of presence of specific antibodies (e.g. Autoimmune)

C)HIV Diagnosis

D)ALL OF THEM

E)NONE OF THEM

A

HIV Diagnosis

and

Determination of presence of specific antibodies (e.g. Autoimmune)

124
Q

Isotypes of Immunoglobulin light chain may be:

A)Alpha and Beta

B)Beta and Sigma

C)Epsilon and Delta

D)Kappa and lambda

A

Kappa and lambda

125
Q

Which one is NOT an advantage of lateral flow test?

A)Fast

B)Chaep

C)not depends on special laboratory

D)Reusable

A

Reusable

126
Q

What kind of labratory method is NOT usable for the evaluation of inflammatory cells?

A)CH50

B)Blood count

C)Cytochemistry

D)FACS

A

CH50

127
Q

What is the effect of adjuvants?

A)Reduce drug-induced damage to normal cells

B)They stimulate myeloid cells through TLRs

C)They bind specifically to damaged cellls

D)They induce apoptosis

A

They stimulate myeloid cells through TLRs

128
Q

Which of these molecules is abscent in the surface of mature B cells?

A)MHC II

B)CD28

C)IgM

D)CD40

A

CD28

(on TH cells)

129
Q

Beta-2 Microglobulin is :

A)An adhesion molecule

B)An Acute Phase Protein

C)A Genetically constant member of the MHCI Protein

D)A CXC Chemokine

A

A Genetically constant member of the MHCI Protein

130
Q

Polypeptide chains in an immunoglobulin molecule are held together primarily with:

A)Ionic Bonds

B)Hydrogen Bonds

C)Disulfide Bonds

D)Hydrophobic Interactions

A

Disulfide Bonds

Low Yield Semmelweis (37 decks)

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