Pharm Final Review Quizlet Flashcards
The study of drugs and their effects on the body.
Pharmacology
The study of the adverse effects of chemicals on living organisms.
Toxicology
Categories of drugs that share similar characteristics or effects.
Drug groups
The study of the effects of drugs and their mechanisms of action.
Pharmacodynamics
The study of the absorption, distribution, metabolism, and elimination of drugs.
Pharmacokinetics
The study of how genes affect a person’s response to drugs.
Pharmacogenomic
A substance used to diagnose, cure, treat, or prevent disease.
Drug
A substance that activates a receptor to produce a biological response.
Agonist
A substance that blocks or dampens the biological response of an agonist.
Antagonist
A protein molecule that receives and responds to a neurotransmitter or hormone.
Receptor
Substances that originate from within an organism.
Endogenous
Substances that originate from outside an organism.
Exogenous
Substances that can cause harm or death when introduced into the body.
Poisons
Poisonous substances produced by living organisms.
Toxins
A substance that activates a receptor but produces a weaker response than a full agonist.
Partial agonist
A substance that binds to a receptor and induces the opposite effect of an agonist.
Inverse agonist
The existence of two or more compounds with the same molecular formula but different spatial arrangements.
Steroisomerism
A substance that counteracts the effects of another substance through different mechanisms.
Physiologic antagonist
An equation used to calculate the pH of a buffer solution.
Henderson Hasselbach Equation
A graph that shows the relationship between the dose of a drug and its pharmacological effect.
Dose-Response Curve
The practice of administering the optimal dose of a drug to achieve the desired effect with minimal side effects.
Rational Dosing
A pharmacokinetic parameter that describes the distribution of a drug throughout the body.
Volume of Distribution (Vd)
A selective barrier that prevents certain substances from entering the brain from the bloodstream.
Blood-Brain Barrier
Categories of neurotransmitters including Esters, Monoamines, Amino Acids, Purines, Peptides, and Inorganic gases.
Neurotransmitter Classes
A class of neurotransmitters that includes Acetylcholine (ACh), which is cholinergic.
Esters of Cholene
A class of neurotransmitters that includes Norepinephrine (NE), Serotonin, and Dopamine, which are adrenergic.
Monoamines
A class of neurotransmitters that includes Glutamate (E) and GABA (I).
Amino Acids
A class of neurotransmitters that includes Adenosine and ATP.
Purines
A class of neurotransmitters that includes Substance P and Endorphins.
Peptides
A class of neurotransmitters that includes Nitric oxide (NO), which is not stored and made as needed.
Inorganic gases
The gut’s own ‘nervous system’.
Enteric nervous system
Leads to smooth muscle contraction and produces second messengers cAMP, DAG, and IP3.
Alpha 1 receptor activation
Characterized by long pre-ganglionic and short post-ganglionic nerve fibers.
Parasympathetic nervous system
Drugs that stimulate adrenergic receptors.
Adrenergic Agonists
Agonists that directly bind to adrenergic receptors.
Direct Acting Adrenergic Agonists
A direct acting adrenergic agonist used primarily for asthma.
Albuterol
A direct acting adrenergic agonist used to treat hypertension.
Clonidine
A direct acting adrenergic agonist used for heart failure.
Dobutamine
A direct acting adrenergic agonist used in shock and heart failure.
Dopamine
A direct acting adrenergic agonist used in anaphylaxis.
Epinephrine
A direct acting adrenergic agonist used for bradycardia.
Isoproterenol
A direct acting adrenergic agonist used in severe hypotension.
Norepinephrine
Agonists that increase the release of norepinephrine.
Indirect Acting Adrenergic Agonists
An indirect acting adrenergic agonist that increases norepinephrine release.
Amphetamine
A drug that has both direct and indirect acting properties.
Ephedrine
SV (70 mL/beat) X HR (75 beat/min) = 5250 ml/min.
Cardiac Output CO (mL/min) =
Compounds like epinephrine and norepinephrine that act on adrenergic receptors.
Catecholamines
Drugs that block adrenergic receptors.
Adrenoceptor Antagonist Drugs
A reversible adrenoceptor antagonist used for hypertension.
Phentolamine
An irreversible adrenoceptor antagonist that forms covalent bonds.
Phenoxybenzamine
Drugs that block beta adrenergic receptors.
Beta Antagonists
A non-selective beta antagonist that works on ?1 and ?2 receptors.
Propranolol
A beta antagonist with mainly ?1 selectivity
Metoprolol .
Drugs that mimic the action of acetylcholine.
Cholinomimetics
Bind to and activate M or N ACh receptors.
Direct Acting Cholinomimetics
Inhibit hydrolysis of ACh and prolong effects of ACh.
Indirect Acting Cholinomimetics
Salivation, Lacrimation, Urination, Diarrhea, Gastrointestinal distress, Emesis, Muscle weakness/Mydriasis
SLUDGE-M An acronym for symptoms of muscarinic excess:
Dilation of the pupil, a symptom of muscarinic excess.
Mydriasis
System for categorizing types of angina. (Insert Different Anginas)
AHA Angina Classification
Vasodilator that increases cGMP for relaxation.
Nitric Oxide (NO)
Medications that increase venous capacitance and reduce preload.
Nitrates
Activate GPCR, increase cAMP for relaxation.
Beta-2 Agonists
Decrease heart demand by reducing heart rate.
Beta-blockers
Reduce calcium influx, leading to smooth muscle relaxation.
Calcium Channel Blockers
Inhibits PDE5, increases cGMP for relaxation.
Sildenafil
Drop in blood pressure upon standing
Orthostatic Hypotension .
Increased heart rate due to blood pressure drop.
Reflex Tachycardia
Calcium blockers targeting peripheral vasculature.
Dihydropyridines
Calcium blocker with cardiac selectivity.
Verapamil
Blocks adrenergic receptors, lowers blood pressure.
Adrenoceptor Antagonist
Decrease sympathetic stimulation via brainstem action.
Centrally Acting Sympathoplegics
Medications that relax vascular smooth muscle.
Vasodilators
Opens K+ channels, dilates arteries and arterioles.
Minoxidil
Dilates arterioles, increases NO production.
Hydralazine
Used in hypertensive emergencies, releases NO.
Sodium Nitroprusside
Condition with reduced cardiac function or filling.
Heart Failure
Reduced cardiac function with decreased ejection fraction.
Systolic Failure
Reduced filling with normal ejection fraction.
Diastolic Failure
Product of stroke volume and heart rate.
Cardiac Output (CO)
Inhibits Na+/K+ ATPase, increases cardiac contractility.
Digoxin
Inactivate cAMP and cGMP, causing vasodilation.
Phosphodiesterase Inhibitors
Disturbances in heart’s electrical conduction.
Arrhythmias
Pacemaker of the heart, regulates contraction rate.
Sinoatrial Node
Medications classified by their mechanism of action.
Antiarrhythmic Agents
Sodium channel blockers affecting cardiac action potential.
Class I Antiarrhythmics