Pharm Exam 4 Study Guide Flashcards
What are the key steps in thrombogenesis?
Thrombogenesis involves platelet adhesion, activation, and aggregation.
What mediators are involved in platelet activation?
ADP, thromboxane A2 (TXA2), and serotonin (5-HT) are released by activated platelets.
What inhibits platelet aggregation?
Prostacyclin (PGI2) inhibits platelet aggregation to prevent excessive clotting.
What are the pathways in the coagulation cascade?
The intrinsic pathway, extrinsic pathway, and common pathway.
What triggers the intrinsic pathway?
The intrinsic pathway is activated by damage inside the vascular system.
What triggers the extrinsic pathway?
The extrinsic pathway is triggered by external trauma.
What is Virchow’s triad?
Stasis, hypercoagulability, and endothelial injury are the causative factors of DVT.
What is the difference between white and red thrombi?
White thrombi are found in high-pressure arteries and are mainly composed of platelets, while red thrombi are found in low-pressure veins and are mainly composed of red blood cells.
What are the risk factors for DVT?
Virchow’s triad, Disseminated Intravascular Coagulation (DIC), and imbalances in the fibrinolytic system and antithrombin.
What is Disseminated Intravascular Coagulation (DIC)?
DIC is a serious condition characterized by widespread clotting and bleeding, often caused by bacterial sepsis, placental abruption, cancer, or massive tissue injury.
What is Heparin-Induced Thrombocytopenia (HIT)?
HIT is a reaction to heparin treatment causing low platelet counts and increased risk of thrombosis.
What is Thrombotic Thrombocytopenic Purpura (TTP)?
TTP is a rare blood disorder causing blood clots in small vessels, often due to genetic mutations or autoimmune reactions.
What is the role of tissue plasminogen activator (TPA) in fibrinolysis?
TPA activates plasminogen to plasmin, which breaks down fibrin and fibrinogen.
What are the four classes of coagulation modifier drugs?
Anticoagulants, anti-platelet drugs, thrombolytics, and hemostatic drugs.
What are indirect thrombin inhibitors?
Indirect thrombin inhibitors include heparin and low molecular weight heparin; they enhance the activity of antithrombin.
What are direct thrombin inhibitors?
Direct thrombin inhibitors like hirudin and dabigatran directly target and inhibit thrombin.
What is the difference between HMW, LMW, and Fondaparinux heparins?
HMW heparin inhibits thrombin and factor Xa, LMW heparin is more specific for factor Xa, and Fondaparinux selectively inhibits factor Xa.
What are the toxicity and contraindications of HMW heparin?
Toxicity includes bleeding and thrombocytopenia; contraindications include active bleeding and severe hypertension.
What are the oral anticoagulants and their mechanisms of action?
Warfarin blocks vitamin K epoxide reductase; factor Xa inhibitors like apixaban and rivaroxaban are more specific.
What are the cardinal symptoms of diabetes?
Polyuria, polydipsia, and polyphagia.
What is the sorbitol pathway?
The sorbitol pathway converts glucose to sorbitol via aldose reductase, leading to peripheral neuropathy and blindness.
What are the types of diabetes tests?
Fasting Plasma Glucose (FPG) Test and Oral Glucose Tolerance Test (OGTT).
What is the structure of insulin?
Insulin is a peptide hormone composed of two chains, A and B, linked by disulfide bonds.
What are insulin secretagogues?
Insulin secretagogues are drugs that stimulate the pancreas to secrete more insulin.