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Advanced Pharm Fall 24' > Analgesic Drugs > Flashcards

Analgesic Drugs Flashcards

1
Q

What is the drug class of Aspirin?

A

Nonsteroidal Anti-Inflammatory Drug (NSAID)

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2
Q

What is the mechanism of action of Aspirin?

A

Irreversible inhibition of COX-1 and COX-2 by covalent acetylation

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3
Q

What are the drug targets of Aspirin?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

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4
Q

What is the expected time for effect of Aspirin?

A

Varies based on dosage and condition being treated

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5
Q

What are the pharmacodynamics of Aspirin?

A

Anti-platelet aggregation at low doses, antipyretic and analgesic at intermediate doses, anti-inflammatory at high doses

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6
Q

What are the pharmacokinetics of Aspirin?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

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7
Q

What is the absorption of Aspirin?

A

Complete

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8
Q

What is the distribution of Aspirin?

A

Small volume of distribution

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9
Q

How is Aspirin excreted?

A

Renal

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10
Q

What is the metabolism of Aspirin?

A

Hepatic

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11
Q

What are the dosage ranges for Aspirin?

A

Low doses (< 300 mg/day), intermediate doses (300-2400 mg/day), high doses (2400-4000 mg/day)

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12
Q

What are key facts about Aspirin?

A

Avoid in patients with gout, risk of Reye syndrome in children with viral infections

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13
Q

What is the drug class of Celecoxib?

A

Selective COX-2 Inhibitor (NSAID)

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14
Q

What is the mechanism of action of Celecoxib?

A

Reversible inhibition of COX-2

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15
Q

What are the drug targets of Celecoxib?

A

COX-2 enzyme

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16
Q

What is the expected time for effect of Celecoxib?

A

Varies based on dosage and condition being treated

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17
Q

What are the pharmacodynamics of Celecoxib?

A

Anti-inflammatory and analgesic

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18
Q

What are the pharmacokinetics of Celecoxib?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

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19
Q

What is the absorption of Celecoxib?

A

Complete

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20
Q

What is the distribution of Celecoxib?

A

Small volume of distribution

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21
Q

How is Celecoxib excreted?

A

Renal

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22
Q

What is the metabolism of Celecoxib?

A

Hepatic

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23
Q

What are the dosage ranges for Celecoxib?

A

Varies based on condition being treated

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24
Q

What are key facts about Celecoxib?

A

Less gastrointestinal bleeding compared to non-selective NSAIDs

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25
Q

What is the drug class of Meloxicam?

A

Selective COX-2 Inhibitor (NSAID)

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26
Q

What is the mechanism of action of Meloxicam?

A

Reversible inhibition of COX-2

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27
Q

What are the drug targets of Meloxicam?

A

COX-2 enzyme

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28
Q

What is the expected time for effect of Meloxicam?

A

Varies based on dosage and condition being treated

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29
Q

What are the pharmacodynamics of Meloxicam?

A

Anti-inflammatory and analgesic

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30
Q

What are the pharmacokinetics of Meloxicam?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

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31
Q

What is the absorption of Meloxicam?

A

Complete

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32
Q

What is the distribution of Meloxicam?

A

Small volume of distribution

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33
Q

How is Meloxicam excreted?

A

Renal

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34
Q

What is the metabolism of Meloxicam?

A

Hepatic

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35
Q

What are the dosage ranges for Meloxicam?

A

Varies based on condition being treated

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36
Q

What are key facts about Meloxicam?

A

Long-acting

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37
Q

What is the drug class of Diclofenac?

A

Nonsteroidal Anti-Inflammatory Drug (NSAID)

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38
Q

What is the mechanism of action of Diclofenac?

A

Reversible inhibition of COX-1 and COX-2

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39
Q

What are the drug targets of Diclofenac?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

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40
Q

What is the expected time for effect of Diclofenac?

A

Varies based on dosage and condition being treated

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41
Q

What are the pharmacodynamics of Diclofenac?

A

Analgesic, antipyretic, and anti-inflammatory

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42
Q

What are the pharmacokinetics of Diclofenac?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

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43
Q

What is the absorption of Diclofenac?

A

Complete

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44
Q

What is the distribution of Diclofenac?

A

Small volume of distribution

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45
Q

How is Diclofenac excreted?

A

Renal

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46
Q

What is the metabolism of Diclofenac?

A

Hepatic

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47
Q

What are the dosage ranges for Diclofenac?

A

Varies based on condition being treated

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48
Q

What are key facts about Diclofenac?

A

Short-acting

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49
Q

What is the drug class of Ibuprofen?

A

Nonsteroidal Anti-Inflammatory Drug (NSAID)

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50
Q

What is the mechanism of action of Ibuprofen?

A

Reversible inhibition of COX-1 and COX-2

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51
Q

What are the drug targets of Ibuprofen?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

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52
Q

What is the expected time for effect of Ibuprofen?

A

Varies based on dosage and condition being treated

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53
Q

What are the pharmacodynamics of Ibuprofen?

A

Analgesic, antipyretic, and anti-inflammatory

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54
Q

What are the pharmacokinetics of Ibuprofen?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

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55
Q

What is the absorption of Ibuprofen?

A

Complete

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56
Q

What is the distribution of Ibuprofen?

A

Small volume of distribution

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57
Q

How is Ibuprofen excreted?

A

Renal

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58
Q

What is the metabolism of Ibuprofen?

59
Q

What are the dosage ranges for Ibuprofen?

A

Varies based on condition being treated

60
Q

What are key facts about Ibuprofen?

A

Short-acting

61
Q

What is the drug class of Indomethacin?

A

Nonsteroidal Anti-Inflammatory Drug (NSAID)

62
Q

What is the mechanism of action of Indomethacin?

A

Reversible inhibition of COX-1 and COX-2

63
Q

What are the drug targets of Indomethacin?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

64
Q

What is the expected time for effect of Indomethacin?

A

Varies based on dosage and condition being treated

65
Q

What are the pharmacodynamics of Indomethacin?

A

Analgesic, antipyretic, and anti-inflammatory

66
Q

What are the pharmacokinetics of Indomethacin?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

67
Q

What is the absorption of Indomethacin?

68
Q

What is the distribution of Indomethacin?

A

Small volume of distribution

69
Q

How is Indomethacin excreted?

70
Q

What is the metabolism of Indomethacin?

71
Q

What are the dosage ranges for Indomethacin?

A

Varies based on condition being treated

72
Q

What are key facts about Indomethacin?

A

Short-acting

73
Q

What is the drug class of Ketorolac?

A

Nonsteroidal Anti-Inflammatory Drug (NSAID)

74
Q

What is the mechanism of action of Ketorolac?

A

Reversible inhibition of COX-1 and COX-2

75
Q

What are the drug targets of Ketorolac?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

76
Q

What is the expected time for effect of Ketorolac?

A

Varies based on dosage and condition being treated

77
Q

What are the pharmacodynamics of Ketorolac?

A

Analgesic, antipyretic, and anti-inflammatory

78
Q

What are the pharmacokinetics of Ketorolac?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

79
Q

What is the absorption of Ketorolac?

80
Q

What is the distribution of Ketorolac?

A

Small volume of distribution

81
Q

How is Ketorolac excreted?

82
Q

What is the metabolism of Ketorolac?

83
Q

What are the dosage ranges for Ketorolac?

A

Varies based on condition being treated

84
Q

What are key facts about Ketorolac?

A

Short-acting

85
Q

What is the drug class of Acetaminophen?

A

Analgesic and Antipyretic

86
Q

What is the mechanism of action of Acetaminophen?

A

Inhibition of COX enzymes in the central nervous system

87
Q

What are the drug targets of Acetaminophen?

A

Cyclooxygenase enzymes (COX-1 and COX-2)

88
Q

What is the expected time for effect of Acetaminophen?

A

Varies based on dosage and condition being treated

89
Q

What are the pharmacodynamics of Acetaminophen?

A

Analgesic and antipyretic

90
Q

What are the pharmacokinetics of Acetaminophen?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

91
Q

What is the absorption of Acetaminophen?

92
Q

What is the distribution of Acetaminophen?

A

Small volume of distribution

93
Q

How is Acetaminophen excreted?

94
Q

What is the metabolism of Acetaminophen?

95
Q

What are the dosage ranges for Acetaminophen?

A

Varies based on condition being treated

96
Q

What are key facts about Acetaminophen?

A

Risk of hepatotoxicity at high doses

97
Q

What is the drug class of Glucocorticoids?

A

Corticosteroids

98
Q

What is the mechanism of action of Glucocorticoids?

A

Inhibition of phospholipase A2 and suppression of immune response

99
Q

What are the drug targets of Glucocorticoids?

A

Glucocorticoid receptors

100
Q

What is the expected time for effect of Glucocorticoids?

A

Varies based on dosage and condition being treated

101
Q

What are the pharmacodynamics of Glucocorticoids?

A

Anti-inflammatory and immunosuppressive

102
Q

What are the pharmacokinetics of Glucocorticoids?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

103
Q

What is the absorption of Glucocorticoids?

104
Q

What is the distribution of Glucocorticoids?

A

Small volume of distribution

105
Q

How are Glucocorticoids excreted?

106
Q

What is the metabolism of Glucocorticoids?

107
Q

What are the dosage ranges for Glucocorticoids?

A

Varies based on condition being treated

108
Q

What are key facts about Glucocorticoids?

A

Risk of adrenal suppression with long-term use

109
Q

What is the drug class of Abatacept?

A

Immunomodulator

110
Q

What is the mechanism of action of Abatacept?

A

Inhibition of T-cell activation

111
Q

What are the drug targets of Abatacept?

A

CD80 and CD86 on antigen-presenting cells

112
Q

What is the expected time for effect of Abatacept?

A

Varies based on dosage and condition being treated

113
Q

What are the pharmacodynamics of Abatacept?

A

Immunosuppressive

114
Q

What are the pharmacokinetics of Abatacept?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

115
Q

What is the absorption of Abatacept?

116
Q

What is the distribution of Abatacept?

A

Small volume of distribution

117
Q

How is Abatacept excreted?

118
Q

What is the metabolism of Abatacept?

119
Q

What are the dosage ranges for Abatacept?

A

Varies based on condition being treated

120
Q

What are key facts about Abatacept?

A

Risk of serious infections

121
Q

What is the drug class of Rituximab?

A

Monoclonal Antibody

122
Q

What is the mechanism of action of Rituximab?

A

Binding to CD20 on B-cells

123
Q

What are the drug targets of Rituximab?

A

CD20 on B-cells

124
Q

What is the expected time for effect of Rituximab?

A

Varies based on dosage and condition being treated

125
Q

What are the pharmacodynamics of Rituximab?

A

Immunosuppressive

126
Q

What are the pharmacokinetics of Rituximab?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

127
Q

What is the absorption of Rituximab?

128
Q

What is the distribution of Rituximab?

A

Small volume of distribution

129
Q

How is Rituximab excreted?

130
Q

What is the metabolism of Rituximab?

131
Q

What are the dosage ranges for Rituximab?

A

Varies based on condition being treated

132
Q

What are key facts about Rituximab?

A

Risk of serious infections

133
Q

What is the drug class of Adalimumab?

A

Monoclonal Antibody

134
Q

What is the mechanism of action of Adalimumab?

A

Binding to TNF-alpha

135
Q

What are the drug targets of Adalimumab?

136
Q

What is the expected time for effect of Adalimumab?

A

Varies based on dosage and condition being treated

137
Q

What are the pharmacodynamics of Adalimumab?

A

Immunosuppressive

138
Q

What are the pharmacokinetics of Adalimumab?

A

Absorbed completely, negligible first-pass hepatic metabolism, tightly bound to serum proteins, small volume of distribution

139
Q

What is the absorption of Adalimumab?

140
Q

What is the distribution of Adalimumab?

A

Small volume of distribution

141
Q

How is Adalimumab excreted?

142
Q

What is the metabolism of Adalimumab?

143
Q

What are the dosage ranges for Adalimumab?

A

Varies based on condition being treated

144
Q

What are key facts about Adalimumab?

A

Risk of serious infections

Advanced Pharm Fall 24' (18 decks)

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