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Advanced Pharm Fall 24' > Coagulation Drugs > Flashcards

Coagulation Drugs Flashcards

1
Q

What is the drug class of Heparin?

A

Anticoagulant

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2
Q

What is the mechanism of action of Heparin?

A

Binds to antithrombin III, enhancing its inhibition of thrombin and factor Xa.

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3
Q

What are the drug targets of Heparin?

A

Thrombin (factor IIa) and factor Xa.

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4
Q

What is an additional information about Heparin?

A

Heparin’s effectiveness varies based on its purity. It is used to prevent clot formation.

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5
Q

What is the drug class of Low Molecular Weight (LMW) Heparin?

A

Anticoagulant

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6
Q

What is the mechanism of action of Low Molecular Weight (LMW) Heparin?

A

Like heparin but more specific for factor Xa.

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7
Q

What are the drug targets of Low Molecular Weight (LMW) Heparin?

A

Factor Xa.

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8
Q

What is an additional information about Low Molecular Weight (LMW) Heparin?

A

LMW heparin has fewer bleeding risks compared to unfractionated heparin.

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9
Q

What is the drug class of Fondaparinux?

A

Anticoagulant

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10
Q

What is the mechanism of action of Fondaparinux?

A

Indirectly inhibits factor Xa by binding to antithrombin III.

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11
Q

What are the drug targets of Fondaparinux?

A

Factor Xa.

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12
Q

What is an additional information about Fondaparinux?

A

Less effective but has fewer bleeding risks.

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13
Q

What is the drug class of Protamine Sulfate?

A

Antidote

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14
Q

What is the mechanism of action of Protamine Sulfate?

A

Binds to heparin, forming a stable complex that neutralizes its anticoagulant effect.

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15
Q

What are the drug targets of Protamine Sulfate?

A

Heparin.

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16
Q

What is an additional information about Protamine Sulfate?

A

Used to reverse the effects of heparin.

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17
Q

What is the drug class of Lepirudin?

A

Direct Thrombin Inhibitor

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18
Q

What is the mechanism of action of Lepirudin?

A

Directly inhibits thrombin.

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19
Q

What are the drug targets of Lepirudin?

A

Thrombin (factor IIa).

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20
Q

What is an additional information about Lepirudin?

A

Used in patients with heparin-induced thrombocytopenia.

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21
Q

What is the drug class of Argatroban?

A

Direct Thrombin Inhibitor

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22
Q

What is the mechanism of action of Argatroban?

A

Directly inhibits thrombin.

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23
Q

What are the drug targets of Argatroban?

A

Thrombin (factor IIa).

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24
Q

What is an additional information about Argatroban?

A

Used in patients with heparin-induced thrombocytopenia.

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25
What is the drug class of Dabigatran?
Direct Oral Anticoagulant (DOAC)
26
What is the mechanism of action of Dabigatran?
Directly inhibits thrombin.
27
What are the drug targets of Dabigatran?
Thrombin (factor IIa).
28
What is an additional information about Dabigatran?
Used for stroke prevention in atrial fibrillation.
29
What is the drug class of Warfarin?
Vitamin K Antagonist
30
What is the mechanism of action of Warfarin?
Inhibits vitamin K epoxide reductase, reducing the synthesis of vitamin K-dependent clotting factors.
31
What are the drug targets of Warfarin?
Vitamin K-dependent clotting factors (II, VII, IX, X).
32
What is an additional information about Warfarin?
Requires monitoring of INR; has various drug interactions.
33
What is the drug class of Rivaroxaban?
Direct Oral Anticoagulant (DOAC)
34
What is the mechanism of action of Rivaroxaban?
Directly inhibits factor Xa.
35
What are the drug targets of Rivaroxaban?
Factor Xa.
36
What is an additional information about Rivaroxaban?
Used for stroke prevention in atrial fibrillation.
37
What is the drug class of Apixaban?
Direct Oral Anticoagulant (DOAC)
38
What is the mechanism of action of Apixaban?
Directly inhibits factor Xa.
39
What are the drug targets of Apixaban?
Factor Xa.
40
What is an additional information about Apixaban?
Used for stroke prevention in atrial fibrillation.
41
What is the drug class of tPA (Tissue Plasminogen Activator)?
Fibrinolytic
42
What is the mechanism of action of tPA?
Converts plasminogen to plasmin, which breaks down fibrin clots.
43
What are the drug targets of tPA?
Plasminogen.
44
What is an additional information about tPA?
Used in acute ischemic stroke.
45
What is the drug class of Streptokinase?
Fibrinolytic
46
What is the mechanism of action of Streptokinase?
Activates plasminogen to plasmin, leading to fibrin clot breakdown.
47
What are the drug targets of Streptokinase?
Plasminogen.
48
What is an additional information about Streptokinase?
Used in acute myocardial infarction.
49
What is the drug class of Urokinase?
Fibrinolytic
50
What is the mechanism of action of Urokinase?
Converts plasminogen to plasmin, leading to fibrin clot breakdown.
51
What are the drug targets of Urokinase?
Plasminogen.
52
What is an additional information about Urokinase?
Used in pulmonary embolism.
53
What is the drug class of ASA (Aspirin)?
Antiplatelet
54
What is the mechanism of action of ASA (Aspirin)?
Inhibits cyclooxygenase (COX), reducing thromboxane A2 production.
55
What are the drug targets of ASA (Aspirin)?
Cyclooxygenase (COX).
56
What is an additional information about ASA (Aspirin)?
Used to prevent ischemic events.
57
What is the drug class of Clopidogrel?
Antiplatelet
58
What is the mechanism of action of Clopidogrel?
Inhibits ADP receptors on platelets, preventing aggregation.
59
What are the drug targets of Clopidogrel?
ADP receptors.
60
What is an additional information about Clopidogrel?
Used to prevent ischemic events.
61
What is the drug class of Abciximab?
Antiplatelet
62
What is the mechanism of action of Abciximab?
Inhibits glycoprotein IIb/IIIa receptors on platelets, preventing aggregation.
63
What are the drug targets of Abciximab?
Glycoprotein IIb/IIIa receptors.
64
What is an additional information about Abciximab?
Used in percutaneous coronary intervention.
65
What is the drug class of Vitamin K?
Hemostatic Agent
66
What is the mechanism of action of Vitamin K?
Essential for the synthesis of clotting factors.
67
What are the drug targets of Vitamin K?
Vitamin K-dependent clotting factors.
68
What is an additional information about Vitamin K?
Used to reverse warfarin effects.
69
What is the drug class of FFP (Fresh Frozen Plasma)?
Blood Product
70
What is the mechanism of action of FFP?
Provides clotting factors.
71
What are the drug targets of FFP?
Clotting factors.
72
What is an additional information about FFP?
Used in bleeding disorders.
73
What is the drug class of Desmopressin?
Hemostatic Agent
74
What is the mechanism of action of Desmopressin?
Increases the release of von Willebrand factor and factor VIII.
75
What are the drug targets of Desmopressin?
von Willebrand factor and factor VIII.
76
What is an additional information about Desmopressin?
Used in von Willebrand disease.
77
What is the drug class of Aminocaproic Acid?
Hemostatic Agent
78
What is the mechanism of action of Aminocaproic Acid?
Inhibits plasminogen activation.
79
What are the drug targets of Aminocaproic Acid?
Plasminogen.
80
What is an additional information about Aminocaproic Acid?
Used to control bleeding.
81
What is the drug class of Tranexamic Acid?
Hemostatic Agent
82
What is the mechanism of action of Tranexamic Acid?
Inhibits plasminogen activation.
83
What are the drug targets of Tranexamic Acid?
Plasminogen.
84
What is an additional information about Tranexamic Acid?
Used for major bleeding.

Advanced Pharm Fall 24' (18 decks)

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