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Advanced Pharm Fall 24' > Coagulation Drugs > Flashcards

Coagulation Drugs Flashcards

1
Q

What is the drug class of Heparin?

A

Anticoagulant

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2
Q

What is the mechanism of action of Heparin?

A

Binds to antithrombin III, enhancing its inhibition of thrombin and factor Xa.

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3
Q

What are the drug targets of Heparin?

A

Thrombin (factor IIa) and factor Xa.

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4
Q

What is an additional information about Heparin?

A

Heparin’s effectiveness varies based on its purity. It is used to prevent clot formation.

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5
Q

What is the drug class of Low Molecular Weight (LMW) Heparin?

A

Anticoagulant

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6
Q

What is the mechanism of action of Low Molecular Weight (LMW) Heparin?

A

Like heparin but more specific for factor Xa.

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7
Q

What are the drug targets of Low Molecular Weight (LMW) Heparin?

A

Factor Xa.

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8
Q

What is an additional information about Low Molecular Weight (LMW) Heparin?

A

LMW heparin has fewer bleeding risks compared to unfractionated heparin.

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9
Q

What is the drug class of Fondaparinux?

A

Anticoagulant

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10
Q

What is the mechanism of action of Fondaparinux?

A

Indirectly inhibits factor Xa by binding to antithrombin III.

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11
Q

What are the drug targets of Fondaparinux?

A

Factor Xa.

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12
Q

What is an additional information about Fondaparinux?

A

Less effective but has fewer bleeding risks.

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13
Q

What is the drug class of Protamine Sulfate?

A

Antidote

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14
Q

What is the mechanism of action of Protamine Sulfate?

A

Binds to heparin, forming a stable complex that neutralizes its anticoagulant effect.

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15
Q

What are the drug targets of Protamine Sulfate?

A

Heparin.

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16
Q

What is an additional information about Protamine Sulfate?

A

Used to reverse the effects of heparin.

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17
Q

What is the drug class of Lepirudin?

A

Direct Thrombin Inhibitor

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18
Q

What is the mechanism of action of Lepirudin?

A

Directly inhibits thrombin.

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19
Q

What are the drug targets of Lepirudin?

A

Thrombin (factor IIa).

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20
Q

What is an additional information about Lepirudin?

A

Used in patients with heparin-induced thrombocytopenia.

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21
Q

What is the drug class of Argatroban?

A

Direct Thrombin Inhibitor

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22
Q

What is the mechanism of action of Argatroban?

A

Directly inhibits thrombin.

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23
Q

What are the drug targets of Argatroban?

A

Thrombin (factor IIa).

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24
Q

What is an additional information about Argatroban?

A

Used in patients with heparin-induced thrombocytopenia.

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25
Q

What is the drug class of Dabigatran?

A

Direct Oral Anticoagulant (DOAC)

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26
Q

What is the mechanism of action of Dabigatran?

A

Directly inhibits thrombin.

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27
Q

What are the drug targets of Dabigatran?

A

Thrombin (factor IIa).

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28
Q

What is an additional information about Dabigatran?

A

Used for stroke prevention in atrial fibrillation.

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29
Q

What is the drug class of Warfarin?

A

Vitamin K Antagonist

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30
Q

What is the mechanism of action of Warfarin?

A

Inhibits vitamin K epoxide reductase, reducing the synthesis of vitamin K-dependent clotting factors.

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31
Q

What are the drug targets of Warfarin?

A

Vitamin K-dependent clotting factors (II, VII, IX, X).

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32
Q

What is an additional information about Warfarin?

A

Requires monitoring of INR; has various drug interactions.

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33
Q

What is the drug class of Rivaroxaban?

A

Direct Oral Anticoagulant (DOAC)

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34
Q

What is the mechanism of action of Rivaroxaban?

A

Directly inhibits factor Xa.

35
Q

What are the drug targets of Rivaroxaban?

A

Factor Xa.

36
Q

What is an additional information about Rivaroxaban?

A

Used for stroke prevention in atrial fibrillation.

37
Q

What is the drug class of Apixaban?

A

Direct Oral Anticoagulant (DOAC)

38
Q

What is the mechanism of action of Apixaban?

A

Directly inhibits factor Xa.

39
Q

What are the drug targets of Apixaban?

A

Factor Xa.

40
Q

What is an additional information about Apixaban?

A

Used for stroke prevention in atrial fibrillation.

41
Q

What is the drug class of tPA (Tissue Plasminogen Activator)?

A

Fibrinolytic

42
Q

What is the mechanism of action of tPA?

A

Converts plasminogen to plasmin, which breaks down fibrin clots.

43
Q

What are the drug targets of tPA?

A

Plasminogen.

44
Q

What is an additional information about tPA?

A

Used in acute ischemic stroke.

45
Q

What is the drug class of Streptokinase?

A

Fibrinolytic

46
Q

What is the mechanism of action of Streptokinase?

A

Activates plasminogen to plasmin, leading to fibrin clot breakdown.

47
Q

What are the drug targets of Streptokinase?

A

Plasminogen.

48
Q

What is an additional information about Streptokinase?

A

Used in acute myocardial infarction.

49
Q

What is the drug class of Urokinase?

A

Fibrinolytic

50
Q

What is the mechanism of action of Urokinase?

A

Converts plasminogen to plasmin, leading to fibrin clot breakdown.

51
Q

What are the drug targets of Urokinase?

A

Plasminogen.

52
Q

What is an additional information about Urokinase?

A

Used in pulmonary embolism.

53
Q

What is the drug class of ASA (Aspirin)?

A

Antiplatelet

54
Q

What is the mechanism of action of ASA (Aspirin)?

A

Inhibits cyclooxygenase (COX), reducing thromboxane A2 production.

55
Q

What are the drug targets of ASA (Aspirin)?

A

Cyclooxygenase (COX).

56
Q

What is an additional information about ASA (Aspirin)?

A

Used to prevent ischemic events.

57
Q

What is the drug class of Clopidogrel?

A

Antiplatelet

58
Q

What is the mechanism of action of Clopidogrel?

A

Inhibits ADP receptors on platelets, preventing aggregation.

59
Q

What are the drug targets of Clopidogrel?

A

ADP receptors.

60
Q

What is an additional information about Clopidogrel?

A

Used to prevent ischemic events.

61
Q

What is the drug class of Abciximab?

A

Antiplatelet

62
Q

What is the mechanism of action of Abciximab?

A

Inhibits glycoprotein IIb/IIIa receptors on platelets, preventing aggregation.

63
Q

What are the drug targets of Abciximab?

A

Glycoprotein IIb/IIIa receptors.

64
Q

What is an additional information about Abciximab?

A

Used in percutaneous coronary intervention.

65
Q

What is the drug class of Vitamin K?

A

Hemostatic Agent

66
Q

What is the mechanism of action of Vitamin K?

A

Essential for the synthesis of clotting factors.

67
Q

What are the drug targets of Vitamin K?

A

Vitamin K-dependent clotting factors.

68
Q

What is an additional information about Vitamin K?

A

Used to reverse warfarin effects.

69
Q

What is the drug class of FFP (Fresh Frozen Plasma)?

A

Blood Product

70
Q

What is the mechanism of action of FFP?

A

Provides clotting factors.

71
Q

What are the drug targets of FFP?

A

Clotting factors.

72
Q

What is an additional information about FFP?

A

Used in bleeding disorders.

73
Q

What is the drug class of Desmopressin?

A

Hemostatic Agent

74
Q

What is the mechanism of action of Desmopressin?

A

Increases the release of von Willebrand factor and factor VIII.

75
Q

What are the drug targets of Desmopressin?

A

von Willebrand factor and factor VIII.

76
Q

What is an additional information about Desmopressin?

A

Used in von Willebrand disease.

77
Q

What is the drug class of Aminocaproic Acid?

A

Hemostatic Agent

78
Q

What is the mechanism of action of Aminocaproic Acid?

A

Inhibits plasminogen activation.

79
Q

What are the drug targets of Aminocaproic Acid?

A

Plasminogen.

80
Q

What is an additional information about Aminocaproic Acid?

A

Used to control bleeding.

81
Q

What is the drug class of Tranexamic Acid?

A

Hemostatic Agent

82
Q

What is the mechanism of action of Tranexamic Acid?

A

Inhibits plasminogen activation.

83
Q

What are the drug targets of Tranexamic Acid?

A

Plasminogen.

84
Q

What is an additional information about Tranexamic Acid?

A

Used for major bleeding.

Advanced Pharm Fall 24' (18 decks)

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