Phaeocromocytoma

Question 1

Which part of the Adrenal Gland are Phaeocromocytomas involved with?

Answer 1

Medulla

Question 2

Which hormone are Phaeocromocytomas involved with?

Answer 2

Catecholamine

Question 3

Phaeocromocytomas are formed by?

Answer 3

Chromaffin cells within adrenal medulla

Question 4

Signs and Symptoms of phaeocromocytomas? (8)

Answer 4

Hypertension
Paroxysmal Attacks
Headache
Sweat
Palpitations
Tremor
Pallor
Anxiety/Fear

Question 5

MEN II are related to which conditions?

Answer 5

Phaeochromocytoma
Medullary Thyroid Cancer
Parathyroid Adenoma

Question 6

Von Hippel Landau Syndrome related to which conditions? (4)

Answer 6

Phaeochromocytoma
Cerebral and Retinal Angiomatosis
Pancreatic and Renal Cysts
Epidydmal Cystadenomas

Question 7

MEN III related to which conditions? (6)

Answer 7

Phaeochromocytoma
Medullary Thyroid Cancer
Mucocutaneous Syndromes
Multiple Neuromas (Von Recklinghausen)
Marfanoid Habitus
Hypertrophied Corneal Nerves

Question 8

Why does a deficit in 21 Hydroxylase cause adrenal hyperplasia? (2)

Answer 8

Lack of 21 Hydroxylase inhibits synthesis of Cortisol removes neg feedback on ACTH and CRH Release.
Increases ACTH secretion enlarges adrenal glands.

Question 9

Which hormones are involved in Phaemochromocytoma?

Answer 9

Norepinephrine and Epinephrine (Catecholamines)

Question 10

Pathophysiology of Phaeocromocytoma? (3)

Answer 10

Adrenal Medulla secretes Adrenaline and Noreadrenaline when stimulations by symp nervous system.
Extra Adrenal Chromaffin Tissue
10% Tumour

Question 11

Diagnosis of Phaecromocytoma? (2)

Answer 11

Urine and Plasma Metanephrines MIBG Scans