Conns Syndrome Flashcards
Which hormone does Conns Syndrome affect?
Aldosterone
What is Conns Syndrome also known as?
Primary Hyperaldosteronism
What is Conns caused by?
Aldosterone producing Tumour
Aldosterone does what in the blood? (3)
Increases Blood Pressure and Volume
Increases Urine K+
What happens to the AR Ratio in Conns
Aldo Up, Renin Down therefore AR Ratio Increases
If PA/PRA Ratio is over >20 when testing for cushings what does this mean?
Primary Hyperaldosteronism
If PA/PRA Ratio is <20 what does this mean?
Secondary Hyperaldosteronism
Essential Hypertension
If PRA is down and PAC Increases what to do?
Investigate for causes of Primary Hyperaldosteronism
If PRA and PAC are down what conditions does this indicate?
Congenital Adrenal Hyperplasia
Exogenous Mineralcortcoid
Cushings
If PRA and PAC are down what conditions does this indicate? (5)
Investigate for causes of Secondary Hyperaldosteronism Diuretic Use Renin Secreting Tumour Malignant Hypertension Aorta Coarctation
What is PRA?
Plasma Renin Activity
What is PAC?
Plasma Aldosterone Concentration
If there is clinical suspicion of Hyperaldosteronism how to screen? (3)
Plasma Renin Activity and Plasma Aldosterone Concentration
If >20 Ratio
Confirmatory Tests for Hyperaldosteronism? (2)
24 Hr Urine Aldosterone >12 ug/day
Urinary Sodium >200 during 4 days salt load
How to establish aldosterone source in Hyperaldosteronism? (3)
CT Scan of Adrenal Glands
Upright Posture Test
Plasma 18 Hydroxycorticosterone
