Multiple Endocrine Neoplasia

Question 1

What is MEN? (3)

Answer 1

Rare
Autosomal Dominant
Endocrine Tumours in Multiple Organs

Question 2

What type of mutation do Multiple Endocrine Neoplasias display? (1)

Answer 2

Germline Gene Mutation

Question 3

What type of Tumour is MEN1

Answer 3

Tumour of Parathyroid Gland

Question 4

MEN1 Tumours are typically accompanied by? (2)

Answer 4

Tumours of Ant Pit and Endocrine Pancreas

Question 5

What type of tumour is MEN2

Answer 5

Medullary Thyroid Cancer

Question 6

MEN2 Tumours usually accompanied by? (2)

Answer 6

Phaeochromocytoma

Parathyroid Tumours

Question 7

MEN2A is typically associated with (3)

Answer 7

Parathyroid Hyperplasia
Medullary Thyroid Carcinoma
phaeochromocytoma

Question 8

MEN2B is typically associated with? (4)

Answer 8

Mucosal Neuroma
Marfanoid Body Habitus
Medullary Thyroid Carcinoma
Pheochromocytoma

Question 9

Features of MEN Type 1 (3)

Answer 9

Primary Hyperaparathyrodism
Pancreatic
Pituitary

Question 10

> 95% of MEN 1 will have?

Answer 10

Hyperparathyrodism

Question 11

What mutation is seen in MEN Type 1

Answer 11

Meinen Mutation (Chr 11)

Question 12

Men Type 1 usually presents in which decade of life?

Answer 12

2nd-4th decade of life

Question 13

Which mutation seen in Men Type 2A?

Answer 13

RET Mutation

Question 14

20-30% of MEN2A have?

Answer 14

Hyperparathyrodism

Question 15

Which part of the history is very important in patients with Primary Hyperparathyrodism?

Answer 15

Family History