Pathophysiology 1 Flashcards

(89 cards)

1
Q

What is pathophysiology?

A

The study of functional or physiologic changes in the body that results from disease processes.

Pathophysiology helps in understanding how diseases affect bodily functions.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

How is disease defined?

A

A deviation from the normal structure or function of any part, organ, system, or combination of these or from a state of wellness.

This definition highlights the multifaceted nature of disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What does the World Health Organization include in its definition of health?

A

Physical, mental, and social well-being.

This comprehensive definition emphasizes that health is not just the absence of disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is homeostasis?

A

The maintenance of a relatively stable internal environment regardless of external changes.

Homeostasis is crucial for overall health and functioning.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What happens when homeostasis is not maintained?

A

Disease may develop.

Disruptions in homeostasis can lead to various health issues.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the components of health?

A
  • Physical well-being
  • Mental well-being
  • Social well-being

These components collectively define a person’s overall health.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are health indicators?

A

Values that occur within a range and may vary depending on technology used for measurement.

Indicators help assess health status and trends.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What factors can cause adjustments in health indicators?

A
  • Age
  • Gender
  • Genetics
  • Environment
  • Activity level

These factors can influence individual health measurements.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the first step in the Seven Steps to Health?

A

Be a nonsmoker and avoid second-hand smoke.

This step emphasizes the importance of avoiding tobacco for overall health.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does the second step in the Seven Steps to Health recommend?

A

Eat 5 to 10 servings of vegetables and fruit a day. Choose high-fiber, lower fat foods.

A balanced diet is essential for maintaining health.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is one of the preventive measures suggested in the Seven Steps to Health?

A

Limit alcohol intake.

Moderation in alcohol consumption is crucial for preventing health issues.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the focus of pathophysiology?

A

Functional (physiologic) changes in the body as a result from disease.

Pathophysiology integrates knowledge of anatomy and physiology.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What does the study of pathology include?

A

Describes structural changes in body tissues caused by disease.

Pathology complements pathophysiology by focusing on physical changes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a primary focus in the prevention of disease?

A

Maintaining routine vaccination programs.

Vaccination is a key strategy for preventing infectious diseases.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the stages of the research process in Health Science?

A
  • Stage 1: Basic science
  • Stage 2: Small number of human subjects
  • Stage 3: Clinical trials

Each stage builds upon the previous one to ensure safety and effectiveness.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the purpose of Stage 1 in the research process?

A

Researchers work to identify a technology that will limit or prevent the disease process.

This stage involves laboratory work and may include animal or cell/tissue cultures.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What characterizes a double-blind study?

A

Neither the participants nor the experimenters know who is receiving a particular treatment.

This approach minimizes bias and ensures reliable results.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

True or False: Clinical trials involve a small number of patients with the disease or risk of the disease.

A

False. Clinical trials involve a large number of patients.

Large sample sizes help improve the reliability of the results.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What’s included in medical history

A

Current and prior illness
Allergies
Hospitalizations
Tx
Specific difficulties
Any type of therapy/ drug

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Normal values for health indicator can be adjusted by?

A

Gender
Age
Genetics
Environment
Activity level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Examination of a dead body is known as

A

Autopsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Biologically programmed cell death is known as

A

Apoptosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

of new cases in a given population with a given time period is known as

A

Incidence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

What is the gross level in medical terminology?

A

Organ or system level

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
What is the microscopic level in medical terminology?
Cellular level
26
What is a biopsy?
Excision of small amounts of living tissue
27
What is an autopsy?
Examination of the body and organs after death
28
What is diagnosis in the context of disease?
Identification of a basic disease through evaluation of signs and symptoms and laboratory tests
29
What does etiology refer to?
Causative factors in a particular disease
30
List some causative factors in etiology.
* Congenital defects * Inherited or genetic disorders * Microorganisms * Immunologic dysfunctions * Degenerative changes * Malignancy * Metabolic, nutritional problems * Trauma, burns, environmental factors
31
What does idiopathic mean?
Cause of disease is unknown
32
What does iatrogenic mean?
Error/treatment/procedure may cause the disease
33
What are predisposing factors in disease?
Age, gender, inherited factors, environment etc.
34
What is prophylaxis?
Preserve health; prevent spread of disease
35
What does prevention encompass?
Vaccinations; dietary/lifestyle modifications; prevention of potentially harmful activities
36
What is pathogenesis?
Development of the disease
37
What are the two types of onset of disease?
* Sudden/acute * Insidious: gradual, vague or mild signs
38
What characterizes acute disease?
Short-term, develops quickly, high fever, severe pain
39
What characterizes chronic disease?
Develops gradually, milder symptoms, often intermitted with acute episodes
40
What is a subclinical state?
Pathologic changes, no obvious manifestations
41
What is a latent state?
No symptoms or clinical signs evident; in infectious diseases: incubation period
42
What is the prodromal period?
Early development of the disease with nonspecific or absent signs
43
What are manifestations in the context of disease?
Clinical evidence with signs and symptoms
44
Differentiate between local and systemic manifestations.
* Local: at site of the problem * Systemic: general indicators of illness, e.g., fever
45
What are signs in medical terminology?
Objective indicators of disease
46
What are symptoms?
Subjective feelings
47
What are lesions?
Specific local change in the tissue
48
What is a syndrome?
Collection of signs and symptoms
49
What are diagnostic tests?
Various laboratory tests appropriate to manifestations and medical history
50
What are remissions and exacerbations?
* Remission: period which manifestations subside * Exacerbation: a worsening of severity
51
What is a precipitating factor?
Condition that triggers an acute episode
52
What are complications in disease?
New secondary or additional problems
53
What is therapy in the context of disease?
Measures to promote recovery/slow progress
54
What are sequelae?
Potential unwanted outcomes
55
What is convalescence or rehabilitation?
Period of recovery and return to healthy state
56
What does morbidity refer to in the context of disease prognosis?
Disease rates within a group
57
What is the definition of mortality?
Relative number of deaths resulting from the disease
58
What is an autopsy?
Postmortem examination
59
What is epidemiology?
Tracking the pattern or occurrence of disease
60
Which organizations are major data collection centers for epidemiology?
* WHO * CDC
61
What does incidence measure?
Number of new cases in a given population within a given time period
62
What is prevalence?
Number of new, old, or existing cases within a given population and time period
63
What characterizes an epidemic?
A higher number of expected cases of an infectious disease occur within an area
64
What is a pandemic?
Involves a higher number of infectious diseases in many regions of the globe
65
Define communicable diseases.
Infectious disease that can spread from one person to another
66
What are notifiable or reportable diseases?
Diseases that must be reported by the physician to designated authorities
67
What does atrophy refer to?
Decrease in the size of cells, resulting in reduced tissue mass
68
Define hypertrophy.
Increase in cell size, resulting in enlarged tissue mass
69
What is hyperplasia?
Increased number of cells, resulting in enlarged tissue mass
70
What does metaplasia involve?
Mature cell type is replaced by a different mature cell type
71
What is dysplasia?
Cells vary in size and shape within a tissue
72
Define anaplasia.
Undifferentiated cells, with variable nuclear and cell structures
73
What does neoplasia mean?
"New growth"—commonly called tumor
74
What is apoptosis?
Programmed cell death; a normal occurrence in the body
75
What does ischemia refer to?
Deficit of oxygen in the cells
76
Define hypoxia.
Reduced oxygen in tissues
77
What is pyroptosis?
Results in lysis causing nearby inflammation
78
What types of damage can lead to cell damage?
* Excessive heat or cold * Radiation exposure
79
What is mechanical damage?
Pressure or tearing of tissue
80
What are the two types of chemical toxins?
* Exogenous: from environment * Endogenous: from inside the body
81
What are microorganisms in the context of cell damage?
Bacteria and viruses, for example
82
What are abnormal metabolites?
* Genetic disorders * Inborn errors of metabolism * Altered metabolism
83
What does necrosis refer to?
Dying cells cause further cell damage due to cellular disintegration
84
What is liquefaction necrosis?
Dead cells liquefy because of release of cell enzymes
85
Define coagulative necrosis.
Cell proteins are altered or denatured—coagulation
86
What is fat necrosis?
Fatty tissue broken down into fatty acids
87
What does caseous necrosis produce?
Thick, yellowish, "cheesy" substance forms
88
What is infarction?
Area of dead cells as a result of oxygen deprivation
89
What is gangrene?
Area of necrotic tissue that has been invaded by bacteria