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FA Review > Pathology: Genes n' such > Flashcards

Pathology: Genes n' such Flashcards

1
Q

BCR-ABL gene is associated with what tumor?

A

CML

ALL

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2
Q

Bcl-2 gene is associated with what tumor?

A

Follicular and undifferentiated lymphomas

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3
Q

BRAF gene is associated with what tumor?

A

Melanoma

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4
Q

c-kit gene is associated with what tumor?

A

Gastrointestinal stromal tumor

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5
Q

c-myc gene is associated with what tumor?

A

Burkitt’s lymphoma

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6
Q

HER2/Neu gene is associated with what tumor?

A

Breast CA

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7
Q

L-myc gene is associated with what tumor?

A

Lung tumor

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8
Q

N-myc gene is associated with what tumor?

A

Neuroblastoma

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9
Q

ras gene is associated with what tumor?v

A

Colon CA

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10
Q

Ret gene is associated with what tumor?

A

MEN 2A and 2B

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11
Q

APC gene is associated with what tumor?

A

Colorectal CA

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12
Q

BRCA1/2 gene is associated with what tumor?

A

Breast and ovarian CA

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13
Q

CPD4/SMAD4 gene is associated with what tumor?

A

Pancreatic CA

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14
Q

DCC gene is associated with what tumor?

A

Colon CA

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15
Q

MEN1 gene is associated with what tumor?

A

MEN type I

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16
Q

NF1 gene is associated with what tumor?

A

Neurofibromatosis type 1

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17
Q

NF2 gene is associated with what tumor?

A

Neurofibromatosis type 2

18
Q

p16 gene is associated with what tumor?

A

Melanoma

19
Q

p53 gene is associated with what tumor?

A

Li-Fraumeni syndrome

20
Q

PTEN gene is associated with what tumor?

A

Breast CA

21
Q

Rb gene is associated with what tumor?

A

Retinoblastoma

22
Q

TSC1 gene is associated with what tumor?

A

tuberous sclerosis

23
Q

TSC2 gene is associated with what tumor?

A

Tuberous sclerosis

24
Q

VHL gene is associated with what tumor?

A

von Hippel-Lindau disease

25
Q

WT1/2 gene is associated with what tumor?

A

Wilms tumor (nephroblastoma)

26
Q

What is Wilms’ tumor

A

Nephroblastoma–often presents in childhood

27
Q

True or false: tumor markers can be used to make a definitive diagnosis of CA

A

False–need biopsy

28
Q

What is WAGR syndrome?

A

a rare genetic syndrome in which affected children are predisposed to develop Wilms tumour (a tumour of the kidneys), Aniridia (absence of the coloured part of the eye, the iris), Genitourinary anomalies, and Retardation

29
Q

Alk Phos is a marker for which tumor?

A

Bone metastases

Paget’s disease of the bone

30
Q

alpha-fetoprotein is a marker for which tumor?

A

Hepatocellular carcinoma

31
Q

beta-hcg is a marker for which tumor?

A

Hydatidiform moles and choriocarcinomas

32
Q

CA-15-3/CA27-29 is a marker for which tumor?

A

Breast CA

33
Q

CA 19-9 is a marker for which tumor?

A

Pancreatic adenocarcinoma

34
Q

CA125 is a marker for which tumor?

A

Ovarian CA

35
Q

Calcitonin is a marker for which tumor?

A

medullary thyroid CA

36
Q

CEA is a marker for which tumor?

A

Carcinoma Embryonic antigen (nonspecific but produced in 70% of colorectal ad pancreatic CA)

37
Q

PSA is a marker for which tumor?

A

Prostate adenocarcinoma

38
Q

s-100 is a marker for which tumor?

A

Neural crest origin (melanomas, neural tumors, schwannomas etc)

39
Q

TRAP is a marker for which tumor?

A

Tartrate-resistant acid phosphatase

Hairy cell leukemia

(TRAP the HAIRY animal)

40
Q

What is hairy cell leukemia?

A

an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes

FA Review (22 decks)

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