Pathology: Genes n' such

Question 1

BCR-ABL gene is associated with what tumor?

Answer 1

CML

ALL

Question 2

Bcl-2 gene is associated with what tumor?

Answer 2

Follicular and undifferentiated lymphomas

Question 3

BRAF gene is associated with what tumor?

Answer 3

Melanoma

Question 4

c-kit gene is associated with what tumor?

Answer 4

Gastrointestinal stromal tumor

Question 5

c-myc gene is associated with what tumor?

Answer 5

Burkitt’s lymphoma

Question 6

HER2/Neu gene is associated with what tumor?

Answer 6

Breast CA

Question 7

L-myc gene is associated with what tumor?

Answer 7

Lung tumor

Question 8

N-myc gene is associated with what tumor?

Answer 8

Neuroblastoma

Question 9

ras gene is associated with what tumor?v

Answer 9

Colon CA

Question 10

Ret gene is associated with what tumor?

Answer 10

MEN 2A and 2B

Question 11

APC gene is associated with what tumor?

Answer 11

Colorectal CA

Question 12

BRCA1/2 gene is associated with what tumor?

Answer 12

Breast and ovarian CA

Question 13

CPD4/SMAD4 gene is associated with what tumor?

Answer 13

Pancreatic CA

Question 14

DCC gene is associated with what tumor?

Answer 14

Colon CA

Question 15

MEN1 gene is associated with what tumor?

Answer 15

MEN type I

Question 16

NF1 gene is associated with what tumor?

Answer 16

Neurofibromatosis type 1

Question 17

NF2 gene is associated with what tumor?

Answer 17

Neurofibromatosis type 2

Question 18

p16 gene is associated with what tumor?

Answer 18

Melanoma

Question 19

p53 gene is associated with what tumor?

Answer 19

Li-Fraumeni syndrome

Question 20

PTEN gene is associated with what tumor?

Answer 20

Breast CA

Question 21

Rb gene is associated with what tumor?

Answer 21

Retinoblastoma

Question 22

TSC1 gene is associated with what tumor?

Answer 22

tuberous sclerosis

Question 23

TSC2 gene is associated with what tumor?

Answer 23

Tuberous sclerosis

Question 24

VHL gene is associated with what tumor?

Answer 24

von Hippel-Lindau disease

Question 25

WT1/2 gene is associated with what tumor?

Answer 25

Wilms tumor (nephroblastoma)

Question 26

What is Wilms' tumor

Answer 26

Nephroblastoma--often presents in childhood

Question 27

True or false: tumor markers can be used to make a definitive diagnosis of CA

Answer 27

False--need biopsy

Question 28

What is WAGR syndrome?

Answer 28

a rare genetic syndrome in which affected children are predisposed to develop Wilms tumour (a tumour of the kidneys), Aniridia (absence of the coloured part of the eye, the iris), Genitourinary anomalies, and Retardation

Question 29

Alk Phos is a marker for which tumor?

Answer 29

Bone metastases | Paget's disease of the bone

Question 30

alpha-fetoprotein is a marker for which tumor?

Answer 30

Hepatocellular carcinoma

Question 31

beta-hcg is a marker for which tumor?

Answer 31

Hydatidiform moles and choriocarcinomas

Question 32

CA-15-3/CA27-29 is a marker for which tumor?

Answer 32

Breast CA

Question 33

CA 19-9 is a marker for which tumor?

Answer 33

Pancreatic adenocarcinoma

Question 34

CA125 is a marker for which tumor?

Answer 34

Ovarian CA

Question 35

Calcitonin is a marker for which tumor?

Answer 35

medullary thyroid CA

Question 36

CEA is a marker for which tumor?

Answer 36

Carcinoma Embryonic antigen (nonspecific but produced in 70% of colorectal ad pancreatic CA)

Question 37

PSA is a marker for which tumor?

Answer 37

Prostate adenocarcinoma

Question 38

s-100 is a marker for which tumor?

Answer 38

Neural crest origin (melanomas, neural tumors, schwannomas etc)

Question 39

TRAP is a marker for which tumor?

Answer 39

Tartrate-resistant acid phosphatase Hairy cell leukemia (TRAP the HAIRY animal)

Question 40

What is hairy cell leukemia?

Answer 40

an uncommon hematological malignancy characterized by an accumulation of abnormal B lymphocytes