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FA Review > Immunology II (pg 208+) > Flashcards

Immunology II (pg 208+) Flashcards

1
Q

What is type I hypersensitivity rxn?

A

Free antigen cross linking on IgE on mast cells and basophils

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2
Q

What causes the delayed type I hypersensitivity rxn?

A

Production of arachidonic acid metabolites

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3
Q

What is the type II hypersensitivity rxn?

A

Cytotoxic = IgM and IgG bind to fixed antigen on other cells, leading to cellular destruction

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4
Q

What are the two types of C regions on the light chains of abs?

A

Kappa and lambda

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5
Q

What are the C regions of the heavy chain of Abs?

A

Part for specificity of IgA, IgG etc.

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6
Q

What are the 3 MOA of type II hypersensitivity?

A
  • Opsonization leading to phagocytosis
  • Complement mediated lysis
  • Antibody-dependent, cell mediated cytotoxicity
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7
Q

What is the direct Coomb’s test?

A

detects antibodies that have adhered to patient’s RBCs (e/g/ test an Rh + infant of an Rh - mother)

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8
Q

What is the indirect Coomb’s test?

A

Detects antibodies that can adhere to other RBCs (e.g. test an Rh - woman for Rh + abs)

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9
Q

What is the MOA of papain on abs? Pepsin?

A 
Papain =  breaks Fc from variable region and light chains apart 
Pepsin = breaks Fc from variable region
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10
Q

What is the Arthus rxn?

A

a local subacute antibody mediated type III reaction

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11
Q

What is type IV hypersensitivity rxn?

A

Delayed type–sensitized T lymphocytes encounter antigen, and then release lymphokines–no ab involved

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12
Q

What are the four T’s of type IV hypersensitivity rxns?

A

T lymphocytes
Transplant rejections
TB skin test
Touching (contact dermatitis)

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13
Q

What are the components of the ACID mnemonic that describes that four types of hypersensitivity rxns?

A
  • Anaphylactic and atopic
  • Cytotoxic (antibody mediated)
  • Immune complexes
  • Delayed
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14
Q

Name the type of hypersensitivity reaction involved: autoimmune hemolytic anemia

A

II

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15
Q

Name the type of hypersensitivity reaction involved: SLE

A

III

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16
Q

Name the type of hypersensitivity reaction involved: MS

A

IV

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17
Q

Name the type of hypersensitivity reaction involved: ITP

A

II

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18
Q

Name the type of hypersensitivity reaction involved: polyarteritis nodosa

A

III

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19
Q

Name the type of hypersensitivity reaction involved: Guillian barre

A

Iv

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20
Q

Name the type of hypersensitivity reaction involved: erythroblastosis fetalis

A

II

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21
Q

Name the type of hypersensitivity reaction involved: post streptococcal GMN

A

III

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22
Q

Name the type of hypersensitivity reaction involved: serum sickness

A

III

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23
Q

Name the type of hypersensitivity reaction involved: arthus rxn

A

III

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24
Q

Name the type of hypersensitivity reaction involved: goodpasture

A

II

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25
Q

Name the type of hypersensitivity reaction involved: Bullous pemphigoid

A

II

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26
Q

Name the type of hypersensitivity reaction involved: pemphigus vulgaris

A

II

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27
Q

Name the type of hypersensitivity reaction involved: GVHD

A

IV

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28
Q

Name the type of hypersensitivity reaction involved: PPD test

A

IV

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29
Q

Name the type of hypersensitivity reaction involved: contact dermatitis

A

IV

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30
Q

Name the type of hypersensitivity reaction involved: rhinitis

A

I

31
Q

What is the pathogenesis and presentation of allergic transfusion rxns?

A
  • type I hypersensitivity rxn against plasma proteins in transfused blood
  • Urticaria, pruritus, wheezing, fever
32
Q

What is the pathogenesis and presentation of anaphylactic transfusion rxns?

A
  • Severe allergic rxn, usually d/t IgA deficiency

- Dyspnea, bronchospasm, hypotension, shock

33
Q

What is the pathogenesis and presentation of febrile, nonhemolytic transfusion rxns?

A
  • Type II hypersensitivity rxn; host abs against donor HLA antigens and leukocytes
  • Fever, HA, chills, flushing
34
Q

What is the pathogenesis and presentation of acute hemolytic transfusion rxns?

A
  • Type II hypersensitivity rxn that causes intravascular hemolysis. D/t ABO blood group incompatibility.
  • Fever, hypotension, tachypnea, tachycardia, flank pain, jaundice
35
Q

What does the Fab determine? Fc?

A 
Fab = Idiotype
Fc = isotype
36
Q

What are the two antibodies that can bind antibodies?

A

IgG and IgM

37
Q

True or false: antibodies are glycoproteins, and their carbs moieties are attached to the CH2 domain

A

True

38
Q

How does isotype switching occur?

A

V(D)J rearrangement

39
Q

What are the autoantibodies in: MG?

A

anti-ACh receptor

40
Q

What are the autoantibodies in: goodpasture

A

Anti BM

41
Q

What are the autoantibodies in: SLE, antiphospholipid syndrome

A

Anti-cardiolipin

Lupus anticoagulant

42
Q

What are the autoantibodies in: CREST (limited scleroderma)

A

Anticentromere

43
Q

What are the autoantibodies in: SLE

A

Anti smith
Anti dsDNA
ANA

44
Q

What are the autoantibodies in: DM I

A

Anti glutamate decarboxylate

45
Q

What are the autoantibodies in: Bullous pemiphgoid

A

Anti hemidesmosome

46
Q

What are the autoantibodies in: drug induced lupus

A

anti-histone

47
Q

What are the autoantibodies in: polymyositis and dermatomyositis

A

Anti Jo
Anti-SRP
Anti-Mi-2

48
Q

What are the autoantibodies in: Hashimoto’s thyroiditis

A

Antimicrosomal

Antithyroglobulin

49
Q

What are the autoantibodies in: primary biliary cirrhosis

A

Antimitochondrial

50
Q

What are the autoantibodies in: Diffuse scleroderma

A

Anti SCL-70 (anti DNA topoisomerase I)

51
Q

What are the autoantibodies in: Autoimmune hepatitis

A

Anti-smooth mucle

52
Q

What are the autoantibodies in: Sjogren’s syndrome?

A

Anti-SSA (ro)

Anti-SSB (la)

53
Q

What are the autoantibodies in: Grave’s disease?

A

Anti TSH

54
Q

What are the autoantibodies in: mixed CT disease?

A

Anti U1 RNP

55
Q

What are the autoantibodies in: GPA (Wegener’s)

A

c-ANCA

56
Q

What are the autoantibodies in: celiac disease

A

IgA antiendomysial

IgA anti tissue transglutaminase

57
Q

Which has D chain, light or heavy

A

Only heavy

58
Q

What are the three segments of the light chain ab?

A

V
J
C

59
Q

What are the autoantibodies in: microscopic polyangiitis

A

p-ANCA

60
Q

What are the auto-antibodies in: Churg Strauss syndrome

A

p-ANCA

61
Q

True or false; light chains have both kappa and lambda light chains

A

False–either or

62
Q

What is the most abundant light chain?

A

Kappa chain

63
Q

The variable domain of the light chains is encoded by random recombination of which light chain exon?

A

V and J

64
Q

What are the autoantibodies in: RA?

A

Rheumatoid factor

Anti CCP

65
Q

What chromosome has the heavy chain of Abs?

A

14

66
Q

The first recombination event in heavy chain rearrangement is what?

A

Between D and J

67
Q

What is the first step of B cell maturation?

A

Development of heavy chain

68
Q

Which comes first: pro B cells, or Pre B cells?

A

Pro

69
Q

B cell receptors are membrane bound Ig that are composed of what?

A

Two heavy and two light chains

70
Q

What is the peaks of serum electrophoresis? (5)

A 
1 = albumin
2 = alpha 1
3 = alpha 2
4 = beta
5 = gamma
71
Q

What are the protein components of MHC class I and II?

A 
I = long alpha and short beta chain
II = Two similar lengths alpha and bet chains (both are membrane spanning)
72
Q

B cells express what CD molecules?

A

CD 5

73
Q

What is the CD protein that is found on all T cells?

A

CD3

74
Q

What is the MOA and use of muromonab?

A
  • ANti CD3 ab to prevent T cell activation

- Used for heart and renal transplants

FA Review (22 decks)

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