Microbiology continued (pg 137) Flashcards
What is the cause of leprosy?
Mycobacterium Leprae
What are the two forms of hansen disease (leprosy)?
Lepromatous
Tuberculoid
What is lepromatous leprosy? Which type of immune response is responsible for this?
Diffuse skin rash with lion like facies.
Th2 response (antibody mediated response)
What is tuberculoid leprosy? Which type of immune response is responsible for this?
Limited skin lesions,
Th1 mediated (cell mediated immune response)
MacConkey agar is specific for what type of bacteria? What is the color that indicates a positive result?
Lactose fermenting bacteria
Pink
What are the three major lactose fermenting bacteria?
Klebsiella
E.coli
Enterobacter
(macconKEE’s agar)
Generally, gram (positive/negative) bacteria are resistant to PCN.
Negative
True or false: Neisseria Gonorrhoeae is an intracellular pathogen, and is often found inside PMNs
True
How do you differentiate between neisseria meningitidis and neisseria Gonorrhoeae?
Maltose fermentation + for meningitidis. Also it has a polysaccharide capsule
Is there a vaccine for Neisseria Gonorrhoeae? Meningitidis?
Yes for meningitidis, no for Gonorrhoea
Which has a polysaccharide capsule: Neisseria Meningitidis or Gonorrhoeae?
Meningitidis
What is the gram stain and morphology of Haemophilus influenzae?
Gram - rod
What is the agar that is needed to grow haemophilus bacteria?
Chocolate
What are the two factors in chocolate agar?
Factor V and X
What are the diseases that haemophilus bacteria cause?
Epiglottitis
Meningitis
OM
Pneumonia
haEMOPhilus
What is the gram stain and morphology of legionella pneumophila?
Gram negative rod
What stain is specific for legionella? What is the agar needed?
Silver stain with Fe, charcoal, and Cysteine
legionnaire sitting around a charcoal campfire with a silver helmet, praying to the cysteine chapel
What is characteristic of the labs for infx with legionella?
hyponatremia
What causes pontiac fever?
Legionella pneumophila
What is the gram stain and morphology of pseudomonas aeruginosa?
Gram negative rod
Does pseudomonas ferment lactose? Is it catalase positive?
- lactose fermentation
+ catalase
What are the diseases that pseudomonas causes?
Pneumonia Sepsis External OM UTI Diabetic Osteomyelitis
What causes ecthyma gangrenosum?
Pseudomonas
What is the treatment for pseudomonas infx?
PCN
What are the four strains of E.coli?
EHEC
ETEC
EPEC
EIEC
What disease doe ETEC cause?
Traveler’s diarrhea via enterotoxins
What disease does EHEC cause? What are the toxins involved?
Hemorrhagic diarrhea via shiga-like toxins
Also, hemolytic-uremia syndrome
What disease does EPEC cause? What is the toxin involved?
Pediatric diarrhea, no toxin produced
What disease does EIEC cause?
Invasive diarrhea
What is the MOA of EIEC?
Disrupts brush border
What is the most common serotype of EHEC?
0157:H7
What are the four diseases that klebsiella causes? (4 As)
Aspiration pneumonia
Abscess in lungs/liver
Alcoholics
diAbetics
Which has flagella: salmonella or shigella?
Salmonella (think salmon swim)
Which can spread hematogenously: salmonella or shigella?
Salmonella
Which has only human reservoirs: salmonella or shigella?
Shigella
How do you distinguish between salmonella and shigella?
H2S test–salmonella is + (think, salmon smell funny).
Are abx effective with salmonella?
No
Which ferments lactose: salmonella or shigella?
Neither
True or false: salmonella typhi is only found in humans
True
Rose spot on the abdomen + diarrhea = ?
Salmonella typhi (typhoid fever)
What does campylobacter jejuni cause?
The major cause of bloody diarrhea, especially in children
Which bacterial infection of the GI tract is associated with the onset of Guillian-Barre syndrome?
Campylobacter
Is campylobacter oxidase positive or negative
Positive
What disease does Yersinia enterocolitica cause? How is it transmitted?
Colitis–transmitted via contaminated milk or cheese
What is the gram stain and morphology of helicobacter pylori? Positive or negative: catalase, urease, oxidase?
Curved gram negative rod that is
All positive for th stuffs
What is the enzyme that allows helicobacter pylori to survive in the low pH of the stomach?
Urease–produces NH4
How can you test for helicobacter pylori?
Urea breath test
What are the three spirochetes?
Leptospira
Treponema
Borrelia
(BLT)
What disease does leptospira interrogans cause? Symptoms?
Leptospirosis
Animal urine exposure + jaundice + ILI= ?
Leptospirosis
What is the causative agent of lyme disease? What genus of tick carries this?
Borrelia Burgdorferi–ixodes tick
What are the symptoms of Lyme disease? (FAKE a keyLYME pie)
Facial nerve palsy
Arthritis
(K)ardiac block
Erythema migrans
What is the treatment for lyme disease?
Doxycycline + ceftriaxone
What is the causative agent of Syphilis?
Treponema pallidum
What is the treatment for syphilis?
PCN
Painless chancre = ?
primary Syphilis
What are the symptoms of secondary syphilis?
Rash on the palms and soles of the feet, condyloma lata
What are the symptoms of tertiary syphilis?
Gummas
Infant with saber shins + Hutchinson incisors = ?
Congenital syphilis
What is Argyll Robertson (prostitute) pupil? What disease is this associated with?
Pupil that will react to accommodation, but not to light
Tertiary syphilis
What is the Jarish-Herxheimer reaction?
Reaction to antibiotics due to release of pyrogens
What is the causative agent of cat scratch fever?
Bartonella
What is anaplasmosis?
Tick borne illness
What is the cause of relapsing fever?
Borrelia recurrentis
What is the usual vector for brucellosis?
Unpasteurized milk
Undulating Fever + diaphoresis + wet hay smell = ?
Brucellosis
What is the usual vector for psittacosis? What are the symptoms?
Parrots–nothing to septicemia + pneumonia
What is the causative agent of Q fever? Vector?
Coxiella burnetii— from aerosols of cattle
What is ehrlichiosis?
Fever from the lone stay tick
What is the causative agent of tularemia? Vector?
Francisella tularensis—from small game
What is the gram stain and morphology of francisella tularensis?
gram negative coccobacillus
What is the causative agent of rocky spotted mountain fever?
Rickettsia rickettsii
What disease does pasteurella multocida cause?
Cellulitis from animal scratches/bites
What is the causative agent of bacterial vaginosis?
Gardnerella vaginalis