Heme/Onc drugs

Question 1

What is the MOA of Heparin?

Answer 1

Cofactor for the activation of antithrombin which decreases thrombin, and factor Xa

Question 2

What lab value is used to follow Heparin use? What is the reversal agent?

Answer 2

PTT

Protamine sulfate

Question 3

What are the major toxicities of Heparin?

Answer 3

HIT

Question 4

What are the two low molecular weight heparins? What are the advantages of these?

Answer 4

Enoxaparin, dalteparin
ACt more on Factor Xa
Less lab following

Question 5

What is the MOA of HIT?

Answer 5

Development of IgG antibodies against heparin bound to platelet factor 4

Question 6

What is the MOA of argatroban?

Answer 6

Direct thrombin inhibitor

Question 7

What is the MOA of Bivalirudin

Answer 7

Direct thrombin inhibitor

Question 8

What is the MOA of Warfarin? What lab value should be followed with this? Reversal agents?

Answer 8

Interferes with normal synthesis and gamma-carboxylation of vit K clotting factors (2, 7, 9, 10)

PT (since more extrinsic pathway effects)

Fresh frozen plasma + vit K

Question 9

What is the MOA and use of apixaban?

Answer 9

Direct factor Xa inhibitor

Anticoagulant

Question 10

What is the MOA and use of rivaroxaban?

Answer 10

Direct factor Xa inhibitor

Anticoagulant