Pathology Flashcards
what is nephritis?
inflammation of the kidney
what is infective nephritis called?
pyelonephritis
what is not infective nephritis called?
glomerulonephritis
what are the three groups of causes of glomerulonephritis?
immune attack of the glomerulus
stuck immune complexes
vasculitis
what is an example of a disease that causes glomerulonephritis by an immune attack of the glomerulus?
goodpasture’s syndrome
what infections can cause immune complexes to become stuck in the glomerulus?
hepatitis
bacteria - strep
HIV
what drugs can cause immune complexes to become stuck in the glomerulus?
gold
penicillamine
what cancers are often associated with glomerulonephritis?
lymphomas
how does nephritic syndrome present? (2)
haematuria
hypertension
what triad of clinical features does nephrotic syndrome present with?
heavy proteinuria
oedema
hyperlipidaemia
what do crescents on pathology of the glomerulus suggest?
rapidly progressive glomerulonephritis
this is bad
what three tests are done on a renal biopsy?
light microscopy
electron microscopy
immunofluorescence
what would be seen upon immunofluorescence of a glomerulus in goodpasture’s?
linear IgG
what is the cause of minimal change disease?
unknown
who gets minimal change disease?
usually children
does minimal change disease present with a nephrotic or nephritic syndrome?
nephrotic
what is given for minimal change disease?
steroids
what does FSGS stand for?
focal segmental glomerulosclerosis
name four causes of FSGS
obesity
HIV
sickle cell disease
IV drug use
who gets FSGS?
usually adults
does FSGS present with a nephrotic or nephritic sydnrome?
nephritic
name five cause of membranous glomerulonephritis
infections drugs malignancy lupus autoimmune disease
what infections can cause membranous glomerulonephritis?
hepatitis
malaria
syphilis
what drugs can cause membranous glomerulonephritis?
penicillamine
NSAIDs
captopril
gold
what malignancies can cause membranous glomerulonephritis?
lung
colon
melanoma
who gets membranous glomerulonephritis?
adults usually
does membranous glomerulonephritis present with a nephrotic or nephritic syndrome?
nephrotic
what is the appearance of membranous glomerulonephritis on pathology?
thick membrane
subepithelial immune deposits
spikes
what causes IgA glomerulonephritis?
genetic
acquired - coeliac
usually post infectious
does IgA glomerulonephritis present with a nephrotic or nephritic syndrome?
nephritic
what is seen on immunofluorescence of IgA glomerulonephritis?
IgA deposition in the mesangium
what cause membranoproliferative glomerulonephritis?
idiopathic
who gets membranoproliferative glomerulonephritis?
adults and children
does membranoproliferative glomerulonephritis present with a nephrotic or nephritic syndrome?
can be either
what is seen on pathology of membranoproliferative glomerulonephritis?
large lobulated glomeruli with thick membranes
tram track appearance
what are the nodules seen in diabetic glomerulosclerosis called?
kimmel stiel wilson lesions
what microvascular renal disease can diabetes cause?
arterial sclerosis
what infections of the kidney can diabetes cause?
pyelonephritis
papillary necrosis
what score can be used to predict renal cancer in cysts?
bosniak score
what are acquired renal cysts often associated with?
long term dialysis
what cause ADPCKD?
mutations in nephrin
what happens to the kidneys in ADPCKD?
develop many cysts
kidney becomes large
what lines the cysts in ADPCKD?
simple epithelium
what are possible secondary effects of the cysts in ADPCKD?
haemorrhage
infarction
rupture
what two systemic effects can occur in ADPCKD?
liver disease
cerebral aneurysms
what is a benign tumour of the kidney called?
oncocytoma
describe the gross appearance of oncocytoma
mahogany brown
central stellate scar
describe the appearance of oncocytoma on pathology
pink
granular cytoplasm
what are the four malignant tumours of the kidney?
chromophobe carcinoma
clear cell carcinoma
papillary carcinoma
collecting duct carcinoma
what are chromophobe carcinomas histologically similar to?
oncocytomas
what is the most common renal cancer?
clear cell carcinoma
what are two risk factors for clear cell carcinoma?
obesity
genetic links
how does clear cell carcinoma often present?
haematuria
palpable mass
hypertension
describe the gross appearance of clear cell carcinoma
bright yellow
where does clear cell carcinoma often spread to?
the renal vein
can spread up the vena cava
what is the least common and worst renal cancer?
collecting duct carcinoma
what is a paediatric renal tumour?
wilm’s tumour
what lines the bladder?
urothelium
what is cystitis?
inflammation of the bladder
what can chronic inflammation of the bladder lead to?
squamous metaplasia
increased risk for SCC
what parasite causes cystitis?
schistosomiasis
how does aseptic cystitis present?
persistent symptoms with persistently negative cultures
what is cystitis cystica?
infolding of the bladder mucosa into cysts
what happens to the kidney in urinary tract obstruction?
dilates
parenchyma becomes atrophic
what is another name for dilation of the collecting system?
hydronephrosis
what is the biggest risk factor for bladder cancer?
smoking
what are the two types of lesions seen in transitional cell carcinoma>
papillary (lower grade) flat CIS (higher)
what is BXO and where does it affect?
balantitis xerotic obliterans
the penis
what is another name for BXO?
lichen sclerosus
what causes BXO?
unknown
who gets BXO?
usually young patients
what causes papilloma of the penis?
HPV
low risk = 6 + 11
high risk = 16 + 18
what is PEiN?
penile intraepithelial neoplasia
essentially a carcinoma in situ
what are the two types of PEiN?
differentiated
dedifferentiated
which type of PEiN is associated with HPV?
dedifferentiated
what is a hydrocele?
accumulation of fluid around the testes
between the layers of the tunica vaginalis
what is spermatocele?
a cystic change within the vas of the epididymis
what is varicocele?
varicosities of the venous plexus that drain the testes
what age group is associated with testicular cancer?
20-40’s
what is the prognosis of testicular cancer?
generally good at all stages
testicular cancer is a cancer of what cells?
germ cells
what are the two groups of testicular cancer?
seminoma
non seminoma
what is the most common type of testicular cancer?
seminoma
what is a risk factor for testicular cancer?
undescended testes
which type of testicular cancer is most aggressive?
non seminoma
are mature teratomas benign or malignant in males?
malignant
what is found in a mature teratoma?
aspects of the three ger, layers
what are three types of malignancy that may be found in a mature teratoma?
yolk sac
embryonal
trophoblast (choriocarcinoma)
what tumour marker is produced by yolk sac tumours?
AFP
what tumour marker is produced by a choriocarcinoma?
beta HCG
patients would have a positive pregnancy test