Parkinsons Disease

Question 1

Dopaminergic

Answer 1

Levodopa (L-dopa)

Question 2

Adverse effects for Levodopa (L-dopa)

Answer 2

dystonia and CNS Effects

Question 3

Administration for Levodopa (L-dopa)

Answer 3

• May combine w/ Carbidopa (Sinemet)
• Goal is the lowest dose; It is the most effective, but has serious adverse effects (dystonia), so start at lowest dose and if side effects occur, change to another med
• DON’T terminate abruptly
• Teach Pt, therapeutic effect occurs in 1-4 weeks

Question 4

Assessment Levodopa (L-dopa)

Answer 4

• Assess for CNS responses/characteristic of Parkinsonism
• Inspect oral cavity after drug administration in patient with dysphagia
• Monitor for safety with ambulation and ADLs (Environmental)

Question 5

Anticholinergic

Answer 5

Benzotropine (Cogentin)

Question 6

Used for Benzotropine (Cogentin)

Answer 6

• The oldest antiparkinson agents

- Most effective for tremor but less effective for bradykinesia

Question 7

MOA of Benzotropine (Cogentin)

Answer 7

• Reduce excess cholinergic effect associated with dopamine deficiency
• Restore neurotransmitter balance in striatum

Question 8

Miscellaneous

Answer 8

Amantadine (Symmetrel)

Question 9

Amantadine (Symmetrel) is used for

Answer 9

• Parkinson’s

- Prophylaxis for Flu

Question 10

Nursing Concerns

Answer 10

• Administer drug early to avoid insomnia
• Avoid driving or other tasks requiring alertness
• Avoid other OTC drugs