Antidiarrheal Agents

Question 1

Classification: Opioid and anti-muscarinic

Answer 1

Diphenoxylate with Atropine (Lomotil)

Question 2

Diphenoxylate with Atropine (Lomotil) does what

Answer 2

Control Severe Diarrhea

Question 3

MOA for Diphenoxylate with Atropine (Lomotil)

Answer 3

Act on smooth muscle cells of intestine to slow peristalsis

Question 4

Bismuth Subsalicylate (Pepto-Bismol) is for?

Answer 4

• Oral OTC for heartburn, Helicobacter infection and diarrhea
• PUD & GERD

Question 5

MOA for Bismuth Subsalicylate (Pepto-Bismol)

Answer 5

Turns to Salicylic Acid in stomach

Question 6

Adverse effects for Bismuth Subsalicylate (Pepto-Bismol)

Answer 6

• Caution for salicylate toxicity if using ASA

- Should not be used for children with flu symptom – Reye’s syndrome

Question 7

Loperamide (Imodium)

Answer 7

Act on smooth muscle cells of intestine to slow peristalsis

Question 8

Octreotide (Sandostatin)

Answer 8

Mimic somatostatin to prevent serotonin & other active peptides that promotes diarrhea
Also inhibit intestinal secretions and enhance absorption

Question 9

Assessment for all antidiarreha agents

Answer 9

• Assess GI and function and bowel movements

- Determine frequency and consistency of BMs

Question 10

Precautions for all antidiarreha agents

Answer 10

• Monitor for dehydration, especially in young children

- Avoid Alcohol and Caffeine