Parkinsonism

Question 1

Pathology of Parkinsonism

Answer 1

Less dopamine great acetylcholine

Question 2

Patient with Parkinsonism are described with exhibiting classical triad which are

Answer 2

Resting tremor
Muscle rigidity
Bradykinesia

Question 3

Parkinson’s disease is a drop in ———— in where ————-

Answer 3

Dopamine in basal ganglia

Question 4

Parkinsonism is an increase in ——- and decrease in ———

Answer 4

Acetyl choline
Dopamine

Question 5

What is levodopa and it’s uses in Parkinsonism

Answer 5

Levodopa is the precursor of dopamine

Dopamine cannot enter the blood brain barrier but levodopa can

Question 6

What drugs is administered with levodopa and why

Answer 6

Caribidopa

Because levodopa is easily broken down by dopa decarboxylase into dopamine

Question 7

Carbidopa is used to do what In Parkinsonism

Answer 7

Block dopa decarboxylase

Question 8

Drugs used for Parkinsonism include

Answer 8

Muscarinic inhibitirs
Dopamine receptors agonist
MAO inhibitors
COMT inhibitors

Question 9

Drugs that inhibit COMT in Parkinsonism is

Answer 9

Tolacapone

Question 10

The monoamine oxidase ( Mao) receptor that works for dopamine is

Answer 10

MAO b

Question 11

Drugs that inhibit MAO b in Parkinsonism

Answer 11

Seregilline and rasagilline

Question 12

Drugs that cause Parkinsonism

Answer 12

Calcium Chanel blockers with dopamine antagonist
Dopamine D2 antagonist
Some anticonvulsant

Question 13

Inhibition of MAO A inhibits what anime specially

Answer 13

NE and serotonin

Question 14

Antiviral drugs with antiparkisonian property is

Answer 14

Amatidine