Parkinsonism Flashcards

1
Q

Pathology of Parkinsonism

A

Less dopamine great acetylcholine

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2
Q

Patient with Parkinsonism are described with exhibiting classical triad which are

A

Resting tremor
Muscle rigidity
Bradykinesia

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3
Q

Parkinson’s disease is a drop in ———— in where ————-

A

Dopamine in basal ganglia

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4
Q

Parkinsonism is an increase in ——- and decrease in ———

A

Acetyl choline
Dopamine

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5
Q

What is levodopa and it’s uses in Parkinsonism

A

Levodopa is the precursor of dopamine

Dopamine cannot enter the blood brain barrier but levodopa can

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6
Q

What drugs is administered with levodopa and why

A

Caribidopa

Because levodopa is easily broken down by dopa decarboxylase into dopamine

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7
Q

Carbidopa is used to do what In Parkinsonism

A

Block dopa decarboxylase

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8
Q

Drugs used for Parkinsonism include

A

Muscarinic inhibitirs
Dopamine receptors agonist
MAO inhibitors
COMT inhibitors

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9
Q

Drugs that inhibit COMT in Parkinsonism is

A

Tolacapone

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10
Q

The monoamine oxidase ( Mao) receptor that works for dopamine is

A

MAO b

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11
Q

Drugs that inhibit MAO b in Parkinsonism

A

Seregilline and rasagilline

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12
Q

Drugs that cause Parkinsonism

A

Calcium Chanel blockers with dopamine antagonist
Dopamine D2 antagonist
Some anticonvulsant

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13
Q

Inhibition of MAO A inhibits what anime specially

A

NE and serotonin

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14
Q

Antiviral drugs with antiparkisonian property is

A

Amatidine

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