Parkinsonism Flashcards
Pathology of Parkinsonism
Less dopamine great acetylcholine
Patient with Parkinsonism are described with exhibiting classical triad which are
Resting tremor
Muscle rigidity
Bradykinesia
Parkinson’s disease is a drop in ———— in where ————-
Dopamine in basal ganglia
Parkinsonism is an increase in ——- and decrease in ———
Acetyl choline
Dopamine
What is levodopa and it’s uses in Parkinsonism
Levodopa is the precursor of dopamine
Dopamine cannot enter the blood brain barrier but levodopa can
What drugs is administered with levodopa and why
Caribidopa
Because levodopa is easily broken down by dopa decarboxylase into dopamine
Carbidopa is used to do what In Parkinsonism
Block dopa decarboxylase
Drugs used for Parkinsonism include
Muscarinic inhibitirs
Dopamine receptors agonist
MAO inhibitors
COMT inhibitors
Drugs that inhibit COMT in Parkinsonism is
Tolacapone
The monoamine oxidase ( Mao) receptor that works for dopamine is
MAO b
Drugs that inhibit MAO b in Parkinsonism
Seregilline and rasagilline
Drugs that cause Parkinsonism
Calcium Chanel blockers with dopamine antagonist
Dopamine D2 antagonist
Some anticonvulsant
Inhibition of MAO A inhibits what anime specially
NE and serotonin
Antiviral drugs with antiparkisonian property is
Amatidine