Ergot Alkaloids

Question 1

Migraine is caused due to

Answer 1

Vasodilation and inflammation of intracranial blood vessels

Question 2

What is an alkaloid

Answer 2

Alkaloids are substance secreted by plant that has effect on human being and animal

Eg atropine(poison)
Morphine ( pain reliever)

Question 3

What are ergot alkaloids

Answer 3

Ergot’s alkaloids are substance gotten from a group of plant called

CLAVICEP PURPURAE
which can cause vasodconstriction in humans

Question 4

Other functions of ergots in humans

Answer 4

Uterine contraction
Postpartum heamorrage
Headaches
Menopausal flashes

Question 5

Mechanism of action of ergots alkaloids

Answer 5

They mimic serotonin dopamine and adrenaline in their constriction abilities

Because they have ergoline structure in their chemical compound

Question 6

Ergots alkaloids stops inflammation of intracranial blood vessels by

Answer 6

Stopping trigeminal nerve from secreting protein

Question 7

Administration of ergots

Answer 7

Orally
By absorbing in the Gi epithelial

Question 8

Metabolism of ergot alkaloids is done by

Answer 8

CYP 3A group

of CYP450 family

Question 9

Half life of ergotamine is

Answer 9

21hrs

Question 10

Half life of dihydroergotamine is

Answer 10

28hrs

Question 11

Which of this is the correct bioavailability of ergotamine in the blood

IV - 99%
IM- 30%
Orally- 1%

Answer 11

Orally

IV 100%
IM 47%

Question 12

Ergotamine is given

Answer 12

Sublingualy

Question 13

Dihydroergotamine is given

Answer 13

Iv
Im
Sc

Question 14

Ergotamine is what classification of ergots alkaloids

Answer 14

Ergopeptine

Question 15

Ergometrine is what classification of ergot alkaloids

Answer 15

Lysergic acid

Question 16

Ergots alkaloids are gotten from

Answer 16

The dried scloretium of clavicep purpurae