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Pharmacology > Leprosy > Flashcards

Leprosy Flashcards

1
Q

Leprosy is an infection caused by

A

Mycobacterium leprea

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2
Q

Leprosy is also known as what disease

A

Hansen disease

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3
Q

Leprosy with solitary skin lesions that are asymmetrical in the skin is what type

A

Tuberculoid leprosy

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4
Q

Leprosy with skin macules is

A

Lepratomous leprosy

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5
Q

Leprosy that is non infectious with no bacterium sample present and few skin lesions are what type according to WHO is

A

Paucibacilliary leprosy

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6
Q

Leprosy that is infectious many bacterium sample present and more skin lesions are what type

A

Multibacilliary leprosy

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7
Q

Mycobacterium leprae causes what

A

Leprosy

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8
Q

We detect mycobacterium leprea by

A

Doing a biopsy and lepromin test

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9
Q

Drugs used in treating leprosy includes

A

Rimfampin
Dapsone
Clifazimine

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10
Q

The Bacteriocidial drugs used in treating leprosy by inhibiting rna transcription is

A

Rimfampin

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11
Q

Dapsone mechanism of action is

A

Ihibiting dihydropteroate synthase in folate synthesis

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12
Q

Leprosy drugs are administered through

A

Orally

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13
Q

In lepromin test how is it carried

A

The test requires injecting an already inactivated leprae mycobacterium specifically in the UPPER LIMBS

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14
Q

Which of these drugs is a Bacteriocidial drug (state the uses of each drugs)

Dapsone
Erythromycin
Rimfampin in
Clofazimine

A

Rifampicin

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15
Q

The leprosy drugs that renders leprosy patient non contagious is

A

Rifampicin

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16
Q

Rifampicin works by

A

Inhibiting rna transcription by stopping the interaction of the beta subunit to rna polymerase

17
Q

The leprosy drugs that accumulate in the kidney liver skin and muscle is

A

Dapsone

18
Q

How is dapsone eliminated

A

It undergoes liver acetylation and then exerted

19
Q

Dapsone adverse effect is

A

Hemolysis in G6PD deficiency
And neuropathic disorder

20
Q

The leprosy drug that is a liver enzyme inducer is

A

Rifampicin

21
Q

Rifampicin kills leprosy in how many days

A

3-7 days

22
Q

Mode of administration of leprosy drug is

A

Orally

23
Q

Multidrug treatment of leprosy is by using

A

3 of the leprosy drugs to manage m leprea especially those ones with dapsone resistance

24
Q

Leprea reaction is gotten from

A

Lepratomous leprosy infection

25
Q

Sulfone syndrome is a leprosy reaction gotten from

A

Dapsone treatment

Pharmacology (24 decks)

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