Anti Microbial Chemotherapy

Question 1

Neoplasm means

Answer 1

A abnormal mass of tissue that forms when cells grow and divide more than they should

Question 2

Two types of neoplasm

Answer 2

Beningn: it grows but does not spread ( non cancerous)

Malignant:: it grows as well as affect nearby tissues ( cancerous)

Question 3

What is chemotherapy

Answer 3

Chemotherapy is the use of drugs to remove any bacteria that causes disease or abnormal growth of cells

Question 4

Pharmacology is the

Answer 4

Study of the effect of drugs on the body

Question 5

Analgesia is a drug

Answer 5

That inhibit pain

Question 6

Example of analgesia

Answer 6

Morphine sulphate

Question 7

An antibiotic

Answer 7

Is a substance produced by a specie to inhibit the growth of another specie

Question 8

Sulphonamides are

Answer 8

Anti folate drugs

Question 9

Anti folate drugs does what

Answer 9

Prevents the use of folate to produce dna in bacterial cell

Question 10

Anti folate drugs include

Answer 10

Sulphonamides and trimethoprim

Question 11

Class 1 use in biochemical therapy

Answer 11

Prevents the production of atp in bacteria by using up glucose and other carbon sources

Question 12

Class 2 biochemical therapy uses

Answer 12

Using of drugs that inhibits an important process majorly in bacteria without affecting the human

Question 13

Bacteriocidial and bacteriostatic drugs

Answer 13

Bacteriocidial : reduces the quantity of the bacteria by killing it

Bacteriostatic: maintains the number but inhibits an important process in the growth of the bacteria

Question 14

Penicillin on bacteria

Answer 14

Inhibits the production of bacteria cell wall ( Bacteriocidial)

Question 15

Chemotherapy acts on the principal of

Answer 15

Selective toxicity

Question 16

Gram negative bacteria

Answer 16

Has one layer peptidoglycan ( cell wall)

Question 17

Gram positive

Answer 17

Has many cell layer ( peptidoglycan )

Question 18

Folate synthesis is what type of therapy

Answer 18

Class 2 reaction

Question 19

Class 3 therapy includes

Answer 19

Cell wall utilization
Ribosome( protein) synthesis
Nucleic acid synthesis

Question 20

Polymixins are

Answer 20

Detergents that disrupts the membrane of bacteria

Question 21

Azoles kill fungal cells by

Answer 21

Inhibiting ergosterol

Question 22

Benzimidazoles and vinca alkaloids drugs on bacteria

Answer 22

Target microtubules and micro filament

Question 23

What is super infections

Answer 23

The appearance of another bacteria during the chemotherapy of another

Question 24

Antibiotic abuse include

Answer 24

1)Excess use of chemotherapy
2)Improper usage
3)Infections that prove non responsive: so u keep using the drugs but by nature the drugs has no effect
Treatment of fever of unknown origin

Question 25

Selective toxicity means

Answer 25

A drug can be used to kill bacteria without affecting blood r harming the host It only harm the microorganisms

Question 26

Types of chemotherapy

Answer 26

Antimicrobial drugs Antineoplastic drugs

Question 27

Types of anti microbial drugs

Answer 27

Broad spectrum Narrow spectrum Antiparasitic Antiviral and anti fungal drugs

Question 28

Drugs that affect cell wall A) tetracycline B)chloramphenicol C) cephalosporin D)streptomycin

Answer 28

Cephalosporin

Question 29

Odd one out and why Aminoglycocides Streptomycin Trimethoprim Erythromycin

Answer 29

Trimethoprim is an anti folate drug The rest are anti ribosomal drugs by preventing the normal production and function of ribosome

Question 30

Drugs that affect the plasma membrane of bacterial

Answer 30

Polymyxins Imidazole Amphotericin

Question 31

Drugs that affect cell wall of bacteria

Answer 31

Penicillin And Cephalosporin

Question 32

Anti folate drugs include A)sulfonamides B)trimethoprim C)clindamycin

Answer 32

Clindamycin This is a anti ribosomal drug

Question 33

anti ribosomal drugs include

Answer 33

Tetracycline Aminoglycosides Streptomycin Chloramphenicol Erythromycin Clindamycin

Question 34

Quinolones drugs does what

Answer 34

They bind to dna or dna gyrase and stop dna replication

Question 35

Nitroimidazoles

Answer 35

Damage dna

Question 36

Rimfampin drugs

Answer 36

Stops rna transcription by blocking the bacteria rna polymerase

Question 37

Antimicrobial drugs can be toxic by

Answer 37

Affecting the normal flora in the GIT especially antibiotics

Question 38

Drugs that affected the plasma membrane of bacteria

Answer 38

Polymyxin Amphotericin Imidazoles

Question 39

Types of aminoglycosides

Answer 39

Streptomycin And gentamycin

Question 40

Aminoglycosides inhibits protein synthesis by

Answer 40

Attacking the 50s and 30s subunit on the ribosome of bacteria majorly 30s Ribosome produces protein And selective toxicity occurs because Human ribosome bears 60s and 40s subunit

Question 41

Erythromycin blocks what ribosome synthesis

Answer 41

50s

Question 42

Tetracycline blocks what ribosome synthesis at

Answer 42

30s

Question 43

Drugs that attack bacterial cell wall are

Answer 43

Penicillin Vancomycin Cephalosporin Bacitracin

Question 44

Types of penicillin include

Answer 44

Penicillin G and V ( both are narrow spectrum)

Question 45

Penicillin G is effective against

Answer 45

Gram positive bacteria only

Question 46

Mechanism of action of penicillin G

Answer 46

Has beta lactamase ( penicillinase) Which hydrolyses the bond of beta lactam on peptidoglycan

Question 47

Penicillin G is administered through

Answer 47

Injection ( paernterally) Stomach acid kills penicillin

Question 48

The penicillin that attacks gram negative bacteria are

Answer 48

Penicillin V

Question 49

Penicillin v is administered by

Answer 49

Orally

Question 50

Cephalosporin first generation is effective against

Answer 50

Gram positive

Question 51

What generation of cephalosporin is broad spectrum

Answer 51

Fourth generation

Question 52

The generation of cephalosporin against gram negative is

Answer 52

2nd generation

Question 53

What cephalosporin generation is effective against gram negative and can enter cns

Answer 53

Third generation

Question 54

What generation of cephalosporin are effective against anaerobes

Answer 54

2nd generation

Question 55

Vancomycin is administered by what route

Answer 55

Orally and intravenously

Question 56

Vancomycin is effective against what bacteria

Answer 56

Staphylococci and enterococcus

Question 57

Anti nucleus drugs are

Answer 57

Quinolones Rimfampin

Question 58

Aminoglycosides are more effective to what type of bacteria

Answer 58

Gram negative bacteria