Pain and Neuronal Plasticity Flashcards
What happens if the cortical area representing a digit is removed ?
the somatosensory map of the digit moves to the surrounding cortex.
What is ibuprofen ?
Inflammatory pain is well controlled initially by drugs such as ibuprofen (non-steroidal antiinflammatory drugs: NSAIDS) and newer drugs that block nerve growth factor (NGF) driven sensitization
What is Gabapentin and it’s usage ?
antagonist of NMDA receptors and calcium blocker at the post-synaptic dorsal horn
Used for neuropathic pain
Is Trigeminal neuralgia unilateral or bilateral ?
What is Complex regional pain syndrome (CRPS)?
Complex regional pain syndrome (CRPS) is a continuous pain disproportionate to any inciting event occurring following tissue injury often associated with nerve lesion
Reorganization of a specific brain area is associated with spontaneous CRPS pain and mechanical hyperalgesia..
What is it ?
Reorganization of contralateral S1 is associated with spontaneous CRPS pain and mechanical hyperalgesia
Reorganization of a specific brain area s associated with motor dysfunction (i.e. tapping)
What is it ?
Reorganization of contralateral M1 is associated with motor dysfunction (i.e. tapping)
Decreased sympathetic outflow might also be responsible for…
Complex regional pain syndrome
Allodynia VS Hyperalgesia ?
• Allodynia: touch becomes painful
• Hyperalgesia: painful stimulation becomes more painful
Mechanism of Hyperalgesia/allodynia to mechanical stimuli is peripheral or central ?
Central
Mechanism of Thermal hyperalgesia is peripheral or central ?
Thermal hyperalgesia occurs at the site of injury and has a peripheral mechanism
NT for Fast pain ?
Glutamate
