NB (065) Practical of Neuropathology Flashcards

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3
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Which cell is responsible for repair of NS injury?

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11
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12
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Mention the two sets of monocyte / macrophage cells in CNS

A

• Parenchymal (resident) microglial cells

• Blood-borne monocytes

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13
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Define Gliosis

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• Gliosis: non specific reaction to any brain injury, e.g. e.g., ischemia, trauma, neurodegenerative diseases, demyelinating diseases, …)

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14
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Define Microglia activation

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• Microglia activation is non specific reaction to any brain injury, e.g. e.g., ischemia, trauma, neurodegenerative diseases, demyelinating diseases, …)

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15
Q

MS affects the central nervous system (CNS) Which part of the CNS is affected?

A. Nerve cells (neurons)

B. Myelin

C. Plaques

D. Vertebrae

A
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16
Q

Although the exact cause of MS is not yet known, which factor may play a role?

A. Environment

B. Viruses

C. Family history

D. All of the above

A

D. All of the above

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18
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what do you see

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19
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What do you see

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20
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identify the type of MS plaque and tell why

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21
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identify the type of MS plaque and tell why

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22
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identify the type of MS plaque and tell why

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23
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identify the type of MS plaque, identify the stain and tell why

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24
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Which of the following genetic phenomena are associated with Huntington’s disease?

A. Trinucleotide repeats

B. Autosomal Dominant Inheritance

C. CAG nucleotide expansion

D. All of the above

A
25
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Individuals with Huntington’s Disease are those who have how many CAG repeats on chromosome 4?

A. 20-31

B. 5-20

C. 31-33

D. 36-120

E. 1-5

A
26
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What type of mutation is Huntington’s disease?

A. Sex-linked dominant

B. Autosomal dominant

C. Autosomal recessive

D. Sex-linked recessive

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27
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Huntington’s disease results in the loss of ……. Function

A. GABAergic

B. Cholinergic

C. Dopamine

D. None of the above

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32
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The peak age of onset for Parkinson’s disease is in the following decade

A. Third

B. Fourth

C. Fifth

D. Sixth

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33
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The part of the brain most affected in Parkinson’s disease is

A. Corpus striatum

B. Putamen

C. Substantia nigra

D. Thalamus

A
34
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Parkinson disease is marked by a shortage of which chemical in the brain?

A. Serotonin

B. GABA

C. Dopamine

D. Norepinephrine

A
35
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Eosinophilic cytoplasmic inclusions seen in the brain cells of a patient with Parkinson’s disease are

A. Golgi bodies

B. Lewy bodies

C. Paschen bodies

D. All of the above

A
36
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What is the nature of Lewy bodies?

A

➢ Lewy body is an aggregate of ⍺ - synuclein

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39
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True or false

α- synuclein and Parkin genes are linked to Parkinson’s disease

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