Biological basis of Neurodegenerative diseases

Question 1

Most AD cases are sporadic, but in roughly xx of patients, there is a family history of dementia

Answer 1

Most AD cases are sporadic, but in roughly 10% of patients, there is a family history of dementia

Question 2

What does APP stand for

Answer 2

Amyloid precursor protein (APP)

Question 3

Answer 3

Question 4

a compound known to cause disturbances often associated with parkinson’s?

Answer 4

MPTP

Question 5

The usual cause of death in parkinson patients?

Answer 5

• Death is usually the result of intercurrent infection or trauma from frequent falls caused by postural instability

Question 6

Answer 6

Question 7

The responsible gene (which encodes a protein called huntingtin) has been localized to the short arm of chromosome xx

Answer 7

The responsible gene (which encodes a protein called huntingtin) has been localized to the short arm of chromosome 4

Question 8

The normal huntingtin gene contains between xx to xx copies of the cytosine-adenine-guanine (CAG) sequence

Answer 8

The normal huntingtin gene contains between 6 to 34 copies of the cytosine-adenine-guanine (CAG) sequence

Question 9

HD: common causes of death include xx and intercurrent infections

Answer 9

Common causes of death include suicide and intercurrent infections