Neurodegeneration & Movement Disorders

Question 1

Question 2

Answer 2

Question 3

Answer 3

Question 4

Answer 4

Question 5

Define Huntington disease (HD) in terms of :
- Curability
- Age onset
-Genetic inheritance
-Pathogenesis
- Three major complications

Answer 5

Question 6

Answer 6

Question 7

The HD gene that codes for ‘huntingtin’ protein ?

Answer 7

IT15

Question 8

Answer 8

The most striking neuropathology in HD occurs within the neostriatum, in which gross atrophy of the caudate nucleus and putamen is accompanied by selective neuronal loss and astrogliosis. Marked neuronal loss also is seen in deep layers of the cerebral cortex. Other regions, including the globus pallidus, thalamus, subthalamic nucleus, substantia nigra, and cerebellum, show varying degrees of atrophy depending on the pathologic grade.

Question 9

Answer 9

Question 10

…..is a characteristic feature of HD and, until recently, the disorder commonly was called Huntington……

Answer 10

Chorea

Question 11

Definition of Chorea ?

Answer 11

Chorea, as defined by the World Federation of Neurology (WFN), is a state of excessive, spontaneous movements, irregularly timed, randomly distributed, and abrupt.

Question 12

Genetic background of Idiopathic PD Parkinson disease ?

Answer 12

Question 13

Medical Treatment of PD ?

Answer 13

•Levo-Dopa (L-Dopa): main treatment

•Dopamine agonists

•Anticholinergics

•Amantadine.

Question 14

Surgical Treatment of PD ?

Answer 14

•Lesioning

•Deep brain stimulation