NB (057) Biological basis of Neurodegenerative Diseases Flashcards
neurodegenerative disorders that are characterized by Progressive Dementia?
neurodegenerative disorders that are characterized by Progressive Dementia?
Causes of Primary degenerative Progressive Dementias in Adults? (4 points)
Causes of Secondary degenerative Progressive Dementias in Adults? (6 points)
The greatest risk factor for Alzheimer’s Disease?
and what comes directly after that?
-Age is the greatest risk factor for AD , a positive family history is the second . Genetic factors estimated to account or 30%-70% of risk.
AD’s Dementia characteristically progresses over xxxx years.
AD’s Dementia characteristically progresses over 5-20 years
Mention the Stages Of Alzheimer’s Disease and explain each.
The Two Hallmark Lesions of Alzheimer’s Disease?
What is β-Amyloid ?
Amyloid beta denotes peptides of 36–43 amino acids that are the main component of the amyloid plaques found in the brains of people with Alzheimer’s disease.
What are Neurofibrillary Tangles ?
genetic cause of autosomal dominant familial AD?
Mutations in APP are a genetic cause of autosomal dominant familial AD
A genetic disorder associated with the devlopment of AD pathology after 30 years?
Trisomomy 21 (Down syndrome) is associated with the devlopment of AD pathology after 30 years
WHAT IS A Biomarker ?
A biomarker is something in the body that can be measured and that reliably indicates the presence or absence of disease, or the risk of later developing a
disease.
What does Diagnostic biomarkers demonstrate in AD?
Role of Prognostic biomarkers?
The two CSF Biomarkers for AD?
How can we differentiate mild to moderate dementia stages from normal aging and from other neurodegerative dementias?
And how can we predict the risk of conversion of MCI to AD?
