073 Bacterial Meningitis Flashcards
The most common bacterial causes of meningitis?
- Neisseria meningitidis (meningococcus)
- Streptococcus pneumoniae (pneumococcus)
- Haemophilus influenzae type b (Hib)
The most important virulence factor for mrningitis-causing bacteria?
And the mode of transmission?
Anothr name for Meningococcus?
describe the morphology of Neisseria meningitides (meningococcus)
the most important virulence factor for Neisseria meningitides (meningococcus)?
The polysaccharide capsule, with its antiphagocytic action, represents the most important virulence factor.
How are Neisseria meningitides (meningococcus) classified into groups?
And mention the most important serogroups.
A, B, C, Y, W135b
The Neisseria meningitides (meningococcus) Serogroup accounting for most meningococcal epidemics and outbreak.
Another virulence factor of Neisseria meningitides due to their Gram- nature?
Route of infection for Neisseria meningitides (meningococcus)?
( 3 points)
Mention three Clinical features of meningococcal sepsis
Another name for Pneumococci?
Describe morphology of Streptococcus pneumoniae (pneumococci)
What does diplococci mean?
a bacterium that occurs as pairs of cocci
The most important virulence factor for Streptococcus pneumoniae (pneumococci)?
Why is the polysaccharide capsule The most important virulence factor for Streptococcus pneumoniae (pneumococci)?
➢ It is antiphagocytic.
➢ It divides the organism into about 90 antigenically different serotypes
Who?
‘A normal colonizer of the respiratory tract, sinuses, and nasal cavity in healthy persons.’
Streptococcus pneumoniae (pneumococci)
Streptococcus pneumoniae (pneumococci) cont.
Individuals at risk include:
Haemophilus influenzae: The genus name is derived from the Greek words meaning…
Blood-loving
Why was Haemophilus influenzae called influenzae?
• H. influenzae occurs as part of the normal flora of the upper respiratory tract.
• It is so-called because it was thought to be the causative agent of influenza.
Comment on the morphology of ‘Haemophilus influenzae’
• Gram –ve capsulated bacilli
How many antigenic types are there for ‘Haemophilus influenzae’? According to what are they classified?
• There are six antigenic types according to polysaccharide capsule
the most common antigenic type of Haemophilus influenzae to cause bacterial meningitis?
Clinical Presentation of Meningitis in Adults?
(6 points)
Mode of infection for meningitis in Neonates?
Most common bacterial causes of neonatal meningitis?
Clinical Presentation of Meningitis in infants?
(8 points)
Laboratory (Specimens) used for Meningitis: lab. diagnosis?
CSF biopsy for meningitis what do you see
CSF biopsy for meningitis what do you see
CSF biopsy for meningitis what do you see
Bacterial meningitis treatment?
Meningitis Chemoprophylaxis?
Prevention of meningitis? (3 points)
- Chemoprophylaxis
- Vaccination
- Droplet precautions
available vaccines for bacterial Meningitis?
- Conjugate Hib polysaccharide capsular vaccine
- Conjugate pneumococcal polysaccharide vaccine
- Meningococcal polysaccharide vaccine (A,C,Y, W135)
