NB (065) Introduction to Neuropathology (Part two)

Question 1

Explain the genetic origin of Huntington disease

Answer 1

Question 2

The molecular pathogenesis of Huntington disease ?

Answer 2

Question 3

Mention 3 symptoms for Huntington disease

Answer 3

Question 4

Gross picture of Huntington disease ?
- general features
- the three structures commonly affected

Answer 4

Question 5

Microscopic picture of Huntington disease ?

Answer 5

Question 6

Answer 6

Question 7

Which is the most likely type of neuron depleted in Huntington disease?

Answer 7

Question 8

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Question 9

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Question 10

immunohistochemical staining for ubiquitin; what do you see ?

Answer 10

Question 11

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Question 12

Mention Motor symptoms of Parkinson’s disease ? (6)

Answer 12

Question 13

Mention non-motor symptoms of Parkinson’s disease ? (9)

Answer 13

Question 14

What does sporadic mean ?

Answer 14

Sporadic refers to a disease that occurs infrequently and irregularly

Question 15

Main environmental factors for Parkinson’s disease ?

Answer 15

Pesticides and air pollution

Question 16

Answer 16

Question 17

Gross shows substantia nigra; identify which is abnormal and why + diagnose

Answer 17

Question 18

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Question 19

What is the structure and composition of Lewy bodies?

Answer 19

Question 20

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Question 21

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Question 22

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Question 23

Types of Alzheimer disease (AD)

Answer 23

Question 24

Types of Alzheimer disease (AD)

Answer 24

Question 25

Answer 25

Question 26

3 Hallmarks of Alzheimer’s ?

Answer 26

Question 27

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Question 28

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Question 29

What are Trans-entorhinal neurons ?

Answer 29

The entorhinal cortex (EC) is a critical element of the hippocampal formation located within the medial temporal lobe (MTL) in primates

Question 30

What does NFT stand for ?

Answer 30

Neurofibrillary tangles (NFT)

Question 31

Answer 31

Question 32

What do you see

Answer 32

Question 33

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Question 34

neurons EM; what do you see ?

Answer 34

Question 35

what’s the staining used ?

Answer 35

Question 36

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Question 37

How To Detect Alzheimer’s Disease Using Histology; what do you see here ?

Answer 37

Question 38

How To Detect Alzheimer’s Disease Using Histology; what do you see here ?

Answer 38

Question 39

What is status spongiosus ?

Answer 39

Question 40

AD

Answer 40