NB (065) Introduction to Neuropathology (Part two) Flashcards by Moustafa Sharawy | Brainscape

Q

Explain the genetic origin of Huntington disease

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The molecular pathogenesis of Huntington disease ?

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Mention 3 symptoms for Huntington disease

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Gross picture of Huntington disease ?
- general features
- the three structures commonly affected

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Microscopic picture of Huntington disease ?

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Which is the most likely type of neuron depleted in Huntington disease?

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immunohistochemical staining for ubiquitin; what do you see ?

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Mention Motor symptoms of Parkinson’s disease ? (6)

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Mention non-motor symptoms of Parkinson’s disease ? (9)

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Q

What does sporadic mean ?

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Sporadic refers to a disease that occurs infrequently and irregularly

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Q

Main environmental factors for Parkinson’s disease ?

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Pesticides and air pollution

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Gross shows substantia nigra; identify which is abnormal and why + diagnose

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What is the structure and composition of Lewy bodies?

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Types of Alzheimer disease (AD)

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Types of Alzheimer disease (AD)

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3 Hallmarks of Alzheimer’s ?

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What are Trans-entorhinal neurons ?

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The entorhinal cortex (EC) is a critical element of the hippocampal formation located within the medial temporal lobe (MTL) in primates

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What does NFT stand for ?

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Neurofibrillary tangles (NFT)

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What do you see

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neurons EM; what do you see ?

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what’s the staining used ?

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How To Detect Alzheimer’s Disease Using Histology; what do you see here ?

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How To Detect Alzheimer’s Disease Using Histology; what do you see here ?

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What is status spongiosus ?

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Q

AD

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