Osteoarthritis Flashcards
definition of osteoarthritis
degenerative, inflammatory process causing progressive loss of hyaline cartilage
pathogenesis (how is develops)
cartilage loss on weight bearing surfaces
subchondral sclerosis & cysts
osteophytes
synovitis capitis
decreased motion
angular limb deformities
abnormal forces on joint surface
septic arthritis
disturbances in cartilage development
what causes a disturbance in cartilage development
OCD
genetic predisposition
feeding managment
composition of hyaline cartilage
chondrocytes
water
collagen type II
GAGs
hyaluronic acid chains
normal extracellular matrix
balance between production - reparation and degradation
PSGAG
negatively charged and binds to water. less psgag = decreased h20 binding capacity
what produces hyaluronic acid
type b synoviocytes and chondrocytes
function of stratum fibrosum
stability and motion
function of stratum synoviale
synovial production
clinical signs of osteoarthritis
joint effusion
lameness
decreased motion in joint
changes in synovia
cartilage damage
new bone formation
diagnosis of OA
visual
palpation
provocating tests
perineural & intrasynovial anaesthesia
arthrocentesis
US
CT
MRI
scintography
arthroscopy
xray
2 main regions of OA
DITJ - distal intertarsal joint
TMTJ - tarsometatarsal joint
AKA bone spavin
pathogenesis of bone spavin
occurs in adults
recurrence of compression and rotation
conformational abnormalities
metabolic causes - protein and mineral imbalance
clinical symptoms of bone spavin
acute onset of lameness
shortened cranial phase of stride
low arc of foot flight
palpable bony swelling
+ve hock flexion test
outside hoof wears off
diagnosis of bone spavin
clinical signs
diagnostic anaesthesia - TibFib
xray examiniation of bone spavin
osteophyte formation
cyst like lesions
bone sclerosis
narrowing of joint space
ancylosis
treatment of bone spavin
injection into tarsometatarsal joint
cunean tenectomy
chemical advancement of arthodesis
surgical arthrodesis
orthopedic shoeing
cyrotherapy
fieringq
normal leucocytes in synovia
<500 (0.5g/l)
leucocytes in synovia for OA
<1000 (1g/l)
leucocytes in synovia for septic joint
20-200G/l
treatment for OA
drugs
stem cell therapy
polyacrylamide hydrogel
arthrotomy
arthroscopy
synoviectomy
chondroplasty
arthrodesis
supplements
drugs for OA
nsaids
corticosteroids
na hyaluronate
psgags
irap
tidren
