Oral Manifestation of Systemic Diseases Flashcards
A 45 year old vegetarian sees his GP after noticing some small red spots on the skin of his trunk. His GP examines him and finds a number of small red papules on the skin of his scalp and face. An FBC is undertaken and he is found to be anaemic with a Hb of 112 g/L and a low MCV and MCH. Which ONE of the following conditions is this man MOST LIKELY to be suffering from?
Campbell de Morgan spots
What are Campbell de Morgan spots?
Appearance?
Colour?
Location?
- Firm red, blue or purple papules
- 0.1–1 cm in diameter.
• When thrombosed, they can appear black in colour until evaluated with a dermatoscope when red or purple colour is more easily seen.
- May develop on any part of the body - most often appear on the scalp, face, lips and trunk.
Hereditary Haemorrhagic Telangiectasia;
AKA?
Type of condition?
Appearance?
Associated with?
- Osler- Weber-Rendu syndrome
- Autosomal dominant condition
- Characterized by telangiectasia on the skin or mucosa. Multiple purpuric spots, may get traumatized and bleed
- Associated with lung, liver and cerebral AVMs
Describe the appearance of Spider naevi
How many spider naevi is considered normal?
Who is it most common for?
- Numerous vessels radiating from central arteriole
- Less than 5
- Common in females
Telangiectasia;
Caused by?
Appearance?
- Widened venules
- Result in threadlike red lines or patterns on the skin
What is the common word for Ecchymosis?
Brusises
A 55-year old woman with rheumatoid arthritis has been having increasing difficulty swallowing food and oral dryness. She is taking methotrexate , folic acid and diclofenac. Which ONE of the following is MOST likely to be the cause of her oral dryness?
Secondary Sjogren’s Syndrome
What is heavily associated with dry mouth? (2)
- Age-related
- Polypharmacy (multiple drugs)
What is the most common causes of xerostomia?
Medication
Sjogren’s syndrome;
Type?
What does it affect?
- Chronic systemic autoimmune exocrinopthy
- Salivary, lacrimal, sweat and GU glands
How is Primary Sjogren’s syndrome different to secondary?
Primary is in isolation whereas secondary is in association of Connective tissue disease such as rheumatoid arthritis
Drug related xerostomia is most likely due to which pathway?
Anticholinergic activity involving M3 muscarinic receptors
A 28 year old man of middle Eastern descent is troubled by severe recurrent oral ulceration. He has had a couple of episodes of genital ulceration. He decides to visit his local Sexual Health clinic. Which ONE of the following findings would be MOST consistent with a diagnosis of Bechet’s disease?
Anterior uveitis
What is Behcet’s Disease
Multisystem disease involving vasculitis appear as recurrent orogenital ulceration
A 68 year old pensioner is found to have significant gingival hypertrophy when he visits his dentist for a review. Which ONE of the following medications is MOST likely to be involved in the aetiology of his gingival condition?
Nifedipine
