OFA Quiz Questions Flashcards
Which of the following DPIs has its shelf-life reduced to 45 days as soon as it removed from its outer pouch, because of problems with moisture sorption?
Twisthaler
Ellipta
Diskhaler
Diskus
Twisthaler
Correct Statements about pressurized metered dose oral inhalers.
Surfactants such as oleic acid can help lubricate the valve
Cosolvents, such as ethanol, are used to help increase solvent polarity
They have metering chambers that deliver accurate volumes upon actuation
When manufactured, they are typically filled under high temperature/pressure
The propellant is both the power source for aerosolization and the vehicle for the drug.
Which of the following was not listed in class as a likely pathway for a drug applied as an eyedrop to get into systemic circulation?
Gastrointestinal Absorption
Conjunctival absorption
Absorption thru canal of Schlemm
Intranasal absorption
Retinal absorption
Retinal absorption
As a formulator of respiratory products, why would you want larger particles for intranasal inhalers than for pulmonary inhalers?
Because nasal mucus is stickier than pulmonary mucus
Because nasal cilia are longer
Because the travel distance of aerosolized particle will be shorter
Because of little turbulence in nasal cavity
Because the larger particles will more likely reach the lungs
Because the travel distance of aerosolized particle will be shorter
What do Naprelan and Slow-K have in common?
they are designed to prevent GI irritation of the drug
which of the following is false about infusion pumps?
Some implantable pumps can deliver drugs intrathecally
Some can be implanted in subclavian fossa
Some can be programmed according to complex circadian patterns
They generally utilize a rate-controlling membrane to control drug release
Insulin pumps exist that utilize glucose sensors separately placed on the abdomen
They generally utilize a rate-controlling membrane to control drug release
What was the reason why it is important to take gastroretentive ciprofloxacin product with a meal?
the pylorus contracts with the meal, delaying passage of swollen tablet from stomach
Which of the following is a false statement about adhesive matrix type transdermal therapeutic systems?
Directly applied heat can increase drug release and absorption
Some are so thin that you can see through them
As exemplified by Daytrana, it can take hours to reach therapeutic levels
The drug is uniformly mixed within an adhesive matrix
About 21 days is the upper limit of application time.
About 21 days is the upper limit of application time.
Which of the following products is formulated as lipid vesicle that are intended to deliver a drug to macrophages in the lungs?
Doxil
Abraxane
Arikayce
Ambisome
Arikayce
