4.1 Vaginal (3)

Question 1

Most common effect of the Vaginal route of drug delivery is (local or Systemic).

Answer 1

Local

Has limited surface area

(e.g. vaginal infections, lubrication, and contraception)

Question 2

Dosage forms include Liquid (_____), Semisolids (creams, gels, ointments), and Solids (Suppositories, film)

Answer 2

douche

Question 3

Other names for suppository are …

Answer 3

pessary, ovule, insert

Question 4

Vaginal film is a ____ dosage form that is similar to oral film where the drug is uniformly dispersed or dissolved in a thin, rapidly disintegrating polymer sheet.

Answer 4

solid

Question 5

The Vagina is a ______ tube, about 6-10 cm long, extending from cervix

Answer 5

fibromuscular

Question 6

A mucous membrane of vagina is composed of ____ epithelium

Answer 6

stratified squamous

Question 7

Some features of vaginal mucous membrane is that it contains folds in the wall which increase surface area (help retain product) called the _______ and a natural microflora (important to maintain).

Answer 7

Rugae

Question 8

Vaginal epithelium is similar to skin, the S.C. comprised of dead corneocytes, and there are intercellular lipids. However, in Vagina the Intercellular lipids do not form an impermeable intercellular lipid envelope. Vaginal SC is (more or less) permeable to water and soluble proteins.

Answer 8

more

Question 9

There is a limited amount of vaginal fluid but vaginal fluid consist mainly of ______ which flow continuously to the vagina.

Answer 9

Cervical secretions

other components include transudates, exfoliated epithelial cells, leukocytes

Question 10

Lactobacillus acidophilus produces lactic acid from glycogen in vaginal epithelial cells. Creates an acidic environment with pH ____ and is bacteriostatic (help maintain microflora)

Answer 10

3.5-4.9

Question 11

Venous drainage of vaginal route (is or is not) to the hepatic portal system.

Answer 11

is not

no hepatic first pass effect

Question 12

There are significant variations in the vaginal mucosa, the amount + composition of vaginal fluid changes during ____ which can affect dissolution and residence time of drug.

Answer 12

menstrual cycle

Question 13

pH is (lower or higher) between about 4 weeks of age and puberty, and upon menopause.

Answer 13

higher

higher pH=inc. risk of infection

Question 14

The thickness changes throughout the menstrual cycle (changes drug absorption) and epithelium becomes (thicker or thinner) upon menopause

Answer 14

thinner

Question 15

Studies demonstrate that some large molecules can be well-absorbed through the vagina, and there can be significant ______, different variation because of vaginal mucosa.

Answer 15

interpatient variability

Question 16

Vaginal route have “_____” where some intravaginal products can accumulate in the uterine tissue.

Answer 16

first uterine pass effect

Question 17

Match vaginal pH by keeping the drug product pH around ___ to maintain infection resistance

Answer 17

4

Question 18

Microbe-free produce so the product does not cause an infection, and to help prevent disruption of natural ____

Answer 18

microflora

Question 19

The product should retain long enough for drug to distribute adequately, retention is important and the ____ + _____ of insertion (high) can be important

Answer 19

rheology, level

Question 20

______– The product should dissolve or melt within a reasonable time, ideally within minutes

Answer 20

Liquefaction

Question 21

Disintegrating tablets spread the (most or least) and, foam and liquid spread the best

Answer 21

least

Question 22

Some drugs are formulated to be ________ which prevent drug leaking too much or too quickly by giving the product a longer residence time and allow for prolonged drug release.

Answer 22

Mucoadhesive (Bioadhesive)

Question 23

_____ are supplied with drug product which is required for intravaginal delivery and to help the drug to be placed high in the vagina

Answer 23

Applicators