3.8 Flashcards
______are fluids designed to be delivered rectally, will spread to sigmoid and descending colon.
Enema
mainly for local action
________ (mesalamine) is a rectal suspension enema used for ulcerative colitis.
Rowasa
_____- offer greater retention and more uniform distribution within the sigmoid colon and rectum compared to an enema.
Rectal foams
mainly for local action
___(budesonide) rectal foam that spreads up to 40 cm from the anal verge and used for ulcerative colitis.
Ulceris
Consideration to applying suppository: Lie on your side, with your lower leg straight and your upper leg ___ forward, towards the stomach.
bent
Consideration to applying suppository:
Using your index finger to gently insert suppository with tapered end first but use your pinky finger if…
if for a child under three y.o
Consideration to applying suppository:
When inserting suppository it must pass the ____, about 1/2 to 1 inch in infants and 1 inch in adults
Sphincter
Consideration to applying suppository:
Avoid excessive movement or exercise for about ____
one hour
To moisten oleaginous suppository it can be …
rubbed with fingers to melt surface (lightly)
To moisten PEG suppositories with …
water (by dipping lightly) before insertion
- Minimize irritation and defecation reflex
- Facilitate dissolution
If half a suppository is prescribed you would cut the suppository _______ with a razor blade. To be more accurate and in case settling during hardening occurs.
Lengthwise (vertically)
A method that requires no mold calibration is …
double casting
Comminute powders to small, uniform particle size to avoid ____ but particle sizes should not be too small that the particles can agglomerate.
settling
Generally, poor when the base is near its solidification point into a mold at room temperature to limit settling and this occurs because solidification of the drug is..
higher viscosity
Pour _____ until all desired cavities are filled to limit settling,.
continuously
